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CN-224231412-U - Fingertip blood detection device containing SFTSV antigen rapid detection colloidal gold test strip

CN224231412UCN 224231412 UCN224231412 UCN 224231412UCN-224231412-U

Abstract

The utility model discloses a fingertip blood detection device containing an SFTSV antigen rapid detection colloidal gold test strip, which aims to simplify the operation flow and improve the detection efficiency and reliability. The device comprises a deformable first cavity and a deformable second cavity, wherein a blood collection channel, a first accommodating space and a second accommodating space for packaging lysate are respectively arranged in the first cavity and the second cavity, the first cavity and the second cavity are communicated through a mixed diversion channel, the first cavity and the mixed diversion channel are respectively blocked by a first diaphragm and a second diaphragm, and the rupture strength of the first diaphragm is higher than that of the second diaphragm. When the device is used, the first cavity is pressed to enable the diaphragm to be sequentially broken, the pyrolysis liquid is sucked into the first accommodating space, then fingertip blood is sucked into the first accommodating space through the collecting channel to be mixed, finally mixed liquid is dripped into the detection test strip, and the device adopts the linearly arranged cavity and the channel to ensure full mixing. The utility model integrates the functions of collection, mixing and transportation, is suitable for the rapid detection of basic units, and obviously reduces the operation time and pollution risk.

Inventors

  • WU JIABING
  • HE JUN
  • LI JIAQI
  • GONG LEI
  • CHEN QINGQING

Assignees

  • 安徽省疾病预防控制中心(省预防医学科学院、省血吸虫病防治研究所)

Dates

Publication Date
20260512
Application Date
20250529

Claims (8)

  1. 1. A fingertip blood detection device containing an SFTSV antigen rapid detection colloidal gold test strip is characterized by comprising: The device comprises a deformable first cavity (1), a first storage space (12) and a second storage space, wherein the first cavity is provided with a blood collection channel (11) and is used for receiving the blood of a fingertip to be tested, and the blood collection channel (11) is blocked by a first diaphragm (13); The deformable second cavity (2) is provided with a second accommodating space (21), and a pyrolysis liquid is encapsulated in the second accommodating space (21); The two ends of the mixed flow guide channel (3) are respectively communicated with the first cavity (1) and the second cavity (2), and the mixed flow guide channel (3) is plugged through a second diaphragm (31); Wherein the first membrane (13) and the second membrane (31) are rupturable under a backlog, and the first membrane (13) has a higher rupture strength than the second membrane (31).
  2. 2. The fingertip blood detection device containing the SFTSV antigen rapid detection colloidal gold test strip according to claim 1, wherein the blood collection channel (11), the first accommodating space (12), the mixed diversion channel (3) and the second accommodating space (21) are arranged linearly in sequence.
  3. 3. The fingertip blood detection device containing the SFTSV antigen rapid detection colloidal gold test strip according to claim 1, wherein the volume of the first accommodating space (12) is 1.2-2 times that of the second accommodating space (21).
  4. 4. The fingertip blood detection device containing the SFTSV antigen rapid detection colloidal gold test strip according to claim 1, wherein the second cavity (2) adopts an elastic expansion structure, and the volume can be increased by 10% -30% when being pressed.
  5. 5. The fingertip blood test device comprising the rapid test colloidal gold test strip for SFTSV antigen according to claim 1, wherein the first membrane (13) and the second membrane (31) are silica gel films with preset breaking lines.
  6. 6. The fingertip blood test device containing the rapid detection colloidal gold test strip for SFTSV antigen as claimed in claim 5, wherein the rupture strength of the first membrane (13) is 20% -50% higher than that of the second membrane (31).
  7. 7. The fingertip blood detection device containing the SFTSV antigen rapid detection colloidal gold test strip according to claim 1 is characterized in that an anti-reflux valve (14) is further arranged in the blood collection channel (11).
  8. 8. The fingertip blood detection device for rapidly detecting colloidal gold test strip containing SFTSV antigen according to claim 7, wherein the anti-reflux valve (14) is a duckbill type one-way valve.

Description

Fingertip blood detection device containing SFTSV antigen rapid detection colloidal gold test strip Technical Field The utility model relates to the technical field of biological medicine, in particular to a fingertip blood detection device containing an SFTSV antigen rapid detection colloidal gold test strip. Background Fever with thrombocytopenia syndrome virus (SFTSV), which has been named as Dabiedada virus by the International Commission on viral classification (ICTV) in recent years, also known as New bunyavirus, is an emerging tick-borne pathogen. The viral infection may lead to fever with thrombocytopenia syndrome (SFTS). The traditional Chinese patent discloses a rapid detection colloidal gold test strip for SFTSV antigen and a preparation method thereof, wherein a double-antibody sandwich method is adopted to detect SFTSVNP antigen, an N protein monoclonal antibody 1G of human large-class Bifida virus prepared in a laboratory is used as a detection antibody, an N protein monoclonal antibody 1E of human large-class Bifida virus marked by colloidal gold is used as a marking antibody, the test strip is formed by sequentially adhering a sample pad, a colloidal gold pad, a cellulose acetate film (NC film) and water-absorbing paper to a PVC bottom plate along the chromatographic direction, the NC film is sequentially coated with a detection line and a quality control line along the chromatographic direction, and the prepared rapid detection colloidal gold test strip for SFTSV antigen can qualitatively detect the large-class Bifida virus in peripheral blood, serum and plasma samples, so that a rapid and reliable virus detection technology suitable for basic units and field application is established. According to the technical scheme, although the detection efficiency and reliability of the large Bifida virus in the blood are improved, the blood for detection needs to be treated by the lysate, the traditional method is that the collected blood is firstly treated, and then the treated blood is transferred to a rapid detection colloidal gold test strip of SFTSV antigen through a suction device, so that the steps are long, and sample pollution or waste is easily caused by improper operation. Therefore, in order to solve the drawbacks of the prior art, it is necessary to design a fingertip blood detection device containing a colloidal gold test strip for rapidly detecting the SFTSV antigen. It should be noted that the foregoing description of the background art is only for the purpose of providing a clear and complete description of the technical solution of the present utility model and is for the convenience of understanding by those skilled in the art, and is not to be construed as merely illustrative of the background art of the present utility model. Disclosure of utility model In order to overcome the defects in the prior art, the utility model aims to disclose a fingertip blood detection device containing an SFTSV antigen rapid detection colloidal gold test strip, so as to simplify the operation flow and improve the detection efficiency and reliability. The utility model discloses a fingertip blood detection device containing an SFTSV antigen rapid detection colloidal gold test strip, which comprises: The first deformable cavity is provided with a blood collection channel and a first accommodating space for receiving the blood of the fingertip to be tested, and the blood collection channel is blocked by a first diaphragm; The deformable second cavity is provided with a second accommodating space, and the second accommodating space is internally packaged with a pyrolysis liquid; The two ends of the mixed diversion channel are respectively communicated with the first cavity and the second cavity, and the mixed diversion channel is blocked by the second diaphragm; Wherein the first membrane and the second membrane are rupturable under backlog and the first membrane has a higher burst strength than the second membrane. In the process of pressing the first cavity, the first diaphragm is firstly ruptured to enable the first accommodating space to be communicated with the second accommodating space, then the second diaphragm is ruptured to enable the first accommodating space to be communicated with the outside along with pressure increase, then the blood collection channel is abutted to fingertip blood, the fingertip blood is sucked into the first accommodating space along with restoration of the first cavity, meanwhile, the pyrolysis liquid in the second accommodating space is sucked into the first accommodating space to be mixed, and finally the first cavity is pressed again to drop the mixed fingertip blood onto the rapid detection colloidal gold test strip for SFTSV antigens. The preferred technical proposal is that the blood collection channel, the first accommodation space, the mixed diversion channel and the second accommodation space are arranged linearly in sequence, which is convenient for mixing