CN-224231687-U - Self-calibration multichannel electrochemical analysis measurement system

CN224231687UCN 224231687 UCN224231687 UCN 224231687UCN-224231687-U

Abstract

The utility model provides a self-calibration multi-channel electrochemical analysis measurement system which comprises an electrochemical measurement part, a combined electrochemical measurement cell plate, a signal adapter and a signal control processing terminal, wherein the combined electrochemical measurement cell plate comprises at least 3 independent electrochemical measurement cells, the electrochemical measurement part comprises at least 3 independent electrochemical measurement channels, the signal adapter comprises an analog part and a digital part, the analog part is used for conducting the independent electrochemical measurement cells and the independent electrochemical measurement channels, the digital part is used for carrying out data interaction with the signal control processing terminal, the independent electrochemical measurement channels are used for monitoring and collecting original signals in the corresponding independent electrochemical measurement cells, and the signal processing terminal is respectively connected with the signal adapter and the multi-channel electrochemical measurement part for carrying out data analysis on the original signals and the signals.

Inventors

SUN JIANJUN
Qin Sainan
DONG CHENGBIN

Assignees

福州大学

Dates

Publication Date: 20260512
Application Date: 20250409

Claims (10)

1. The self-calibration multichannel electrochemical analysis measurement system is characterized by comprising an electrochemical measurement part, a combined electrochemical measurement Chi Ban (3), a signal adapter and a signal control processing terminal, wherein the combined electrochemical measurement cell plate comprises at least 3 independent electrochemical measurement cells (321), and the electrochemical measurement part comprises at least 3 independent electrochemical measurement channels; The signal adapter comprises an analog part and a digital part, wherein the analog part is used for conducting an independent electrochemical measuring cell and an independent electrochemical measuring channel, and the digital part is used for carrying out data interaction with a signal control processing terminal; The signal processing terminal is respectively connected with the signal adapter and the multichannel electrochemical measuring part, and performs data analysis on the received original signals and signals.
2. The self-calibrating multi-channel electrochemical analytical measurement system of claim 1, wherein each of the independent electrochemical measurement cells is in a dual electrode mode of operation, the electrodes being a working electrode and a counter electrode, respectively, or wherein each of the independent electrochemical measurement cells is in a three electrode mode of operation, the working combination of the electrodes comprising a plurality of combinations of 1 or more working electrodes, 1 or more counter electrodes, and 1 or more reference electrodes; The independent electrochemical measuring cells are distributed in an array at the combined electrochemical measuring cell plate, the part of the combined electrochemical measuring cell Chi Bande is provided with a thimble connected with the electrode, the thimble and the independent electrochemical measuring cell are overlapped in the thickness direction of the combined electrochemical measuring cell plate, the thimble is used for outputting the acquisition signal of the electrode through a bottom port, The combined electrochemical measuring cell plate further comprises a circuit connecting plate, wherein an input port of the circuit connecting plate is respectively communicated with each electrode in the independent electrochemical measuring cell, an output port of the circuit connecting plate is communicated with an input end of the signal adapter, the electrodes are directly arranged at the circuit connecting plate, and an aptamer required by electrochemical analysis is fixed on the electrodes to form an electrochemical aptamer sensor.
3. The self-calibration multi-channel electrochemical analysis measurement system according to claim 2, wherein the working electrode (3212), the counter electrode (3211) and the reference electrode (3213) are microelectrodes, the counter electrode is a segment of circular arc electrode with the working electrode as a center or is a plurality of segments of circular arc electrodes connected together, and the circular arc electrode at least partially surrounds the working electrode; The working electrodes are positioned at the bottom of each independent electrochemical measuring cell and distributed in an array, The circuit connection plate at least partially surrounds the region of the independent electrochemical measurement cell; the circuit connection board is positioned on the back of the area where the independent electrochemical measuring cell is positioned.
4. A self-calibrating multi-channel electrochemical analytical measurement system according to claim 3, characterized in that the electrodes within the separate electrochemical measurement cells are arranged insulated from each other at the bottom of the separate electrochemical measurement cells.
5. A self-calibrating multi-channel electrochemical analytical measurement system according to claim 1, wherein the number of independent electrochemical measurement channels contained in the multi-channel electrochemical measurement section is equal to or less than the number of independent electrochemical measurement cells contained in the combined electrochemical measurement cell plate, each of the independent electrochemical measurement channels communicating with at least one of the independent electrochemical measurement cells without intersecting.
6. A self-calibrating multi-channel electrochemical analytical measurement system according to claim 5, wherein each of the independent electrochemical measurement channels is capable of performing independent electrochemical measurements.
7. The self-calibrating multi-channel electrochemical analytical measurement system of claim 4, wherein the volume of the detection solution in each of the independent electrochemical measurement cells is 0.01 mL-2.0 mL.
8. A self-calibrating multi-channel electrochemical analytical measurement system according to claim 1, characterized in that the separate electrochemical measurement cells on the combined electrochemical measurement cell plate comprise a calibration cell and a sample cell to be measured.
9. A self-calibrating multi-channel electrochemical analytical measurement system according to claim 8, characterized in that the number of calibration cells is not less than 2.
10. The self-calibrating multi-channel electrochemical analytical measurement system of claim 1, wherein the signal control processing terminal is configured to send control commands to the signal adapter and the electrochemical measurement section, respectively.

Description

Self-calibration multichannel electrochemical analysis measurement system Technical Field The utility model relates to the technical field of analysis and detection, in particular to a self-calibration multichannel electrochemical analysis and measurement system. Background In clinical medication, some medicines face the condition that the therapeutic concentration window is narrower, the low blood concentration has the risk of insufficient exposure of the medicines, which can delay the treatment of patients and inhibit the disease progression, and the increase of the medication concentration can increase the toxicity risk of the medicines and increase the probability of adverse events of the patients, so that the reasonable control of the blood drug exposure concentration of the patients is of great importance. In addition, because of different individual differences of patients, the tolerance difference of the patients to the medicines is larger, and detecting the blood concentration of the patients and providing the patients with a proper medicine concentration window has important significance for realizing clinical individuation and accurate treatment. The current clinic mainly uses the techniques of enzyme-linked immunosorbent assay, high performance liquid chromatography, liquid chromatography tandem mass spectrometry and the like to realize the monitoring of therapeutic drugs, wherein the liquid chromatography tandem mass spectrometry is specific, sensitive and reliable, and gradually becomes the main monitoring method of clinical blood concentration due to the advantages of high precision, accuracy, sensitivity and high flux detection. However, this method inevitably faces pretreatment of clinical samples and cumbersome detection procedures. The electrochemical analysis is an important experimental means, is widely applied to the fields of environmental monitoring, biomedical research, material science and the like, has various advantages, including the advantages of simple operation, high sensitivity, rapid detection, low equipment requirement, easy miniaturization, integration and the like, and can become one of the best means for clinical drug monitoring. Conventional electrochemical analysis methods typically employ a single channel mode, i.e., only one electrode can be measured at a time, which is not only inefficient, but also has limited analytical capabilities for multi-component complex systems. The detection efficiency and accuracy are not very high, so that the development of a device capable of realizing the simultaneous detection of a plurality of standard samples and samples to be detected is more valuable for the rapid detection adaptation of biological, medical and electroplating liquid and the like samples to be detected. Disclosure of utility model The self-calibration multichannel electrochemical analysis measurement system provided by the utility model has the advantages of higher efficiency than the existing electrochemical detection system, capability of realizing simultaneous detection of multiple points, high reliability, self calibration, high instantaneity and small sample size. The utility model adopts the following technical scheme. The self-calibration multichannel electrochemical analysis measurement system comprises an electrochemical measurement part (1), a combined electrochemical measurement Chi Ban (3), a signal adapter (2) and a signal control processing terminal (4), wherein the combined electrochemical measurement cell plate comprises at least 3 independent electrochemical measurement cells (321), and the electrochemical measurement part comprises at least 3 independent electrochemical measurement channels; The signal adapter comprises an analog part and a digital part, wherein the analog part is used for conducting an independent electrochemical measuring cell and an independent electrochemical measuring channel, and the digital part is used for carrying out data interaction with a signal control processing terminal; The signal processing terminal is respectively connected with the signal adapter and the multichannel electrochemical measuring part, and performs data analysis on the received original signals and signals. Each independent electrochemical measuring cell is in a double-electrode working mode, and the electrodes are respectively a working electrode and a counter electrode, or each independent electrochemical measuring cell is in a three-electrode working mode, and the working combination of the electrodes comprises a plurality of combinations of more than or equal to 1 working electrode, more than or equal to 1 counter electrode and more than or equal to 1 reference electrode; as shown in fig. 5, 6, 9 and 10, the independent electrochemical measuring cells are distributed in an array at the combined electrochemical measuring cell plate, the combined electrochemical measuring Chi Bande is provided with a thimble (35) connected with the electrode, th