Search

CN-224231722-U - Kit for detecting concentration of anticoagulants in blood plasma

CN224231722UCN 224231722 UCN224231722 UCN 224231722UCN-224231722-U

Abstract

The utility model discloses a reagent kit for detecting concentration of anticoagulants in blood plasma, which comprises a kit body and a reagent rack arranged in the kit body, wherein the reagent rack is matched with the internal volume of the kit body and used for accommodating an extraction liquid container, a quality control product container and a calibrator container, the reagent rack comprises a guide layer and a lower limit layer and an upper limit layer between the guide layer and the lower limit layer, the guide layer is provided with an extraction liquid container guide hole, a quality control product container guide hole and a calibrator container guide hole, the lower limit layer and the upper limit layer are respectively provided with a lower limit hole and an upper limit hole, and a side wall accommodating groove is formed in one side of the side wall of the reagent rack, which faces the side wall of the kit body. When the kit for detecting the concentration of the anticoagulation medicine in the blood plasma is used, the reagent rack is integrally taken out, each container does not need to be taken out of the reagent rack independently, the risks of confusion and possibility of turning over are avoided, the lower limiting hole and the upper limiting hole play a role in limiting and fixing the container, the transportation is convenient, and built-in non-container articles such as instructions and the like are not easy to lose.

Inventors

  • ZHU LEI
  • TANG CAIYUN
  • HAN YINGXIN
  • GENG RUI
  • LI ZHENG

Assignees

  • 苏州药明泽康生物科技有限公司
  • 上海奥测医学检验所有限公司

Dates

Publication Date
20260512
Application Date
20241231

Claims (8)

  1. 1. The utility model provides a reagent kit for concentration detection of anticoagulants in blood plasma, its characterized in that includes the box body and places in the box body the reagent frame, the reagent frame with the interior volume phase-match of box body is used for holding extract container, quality control article container and calibrator container, the reagent frame includes: The guide layer is arranged at a position, close to the top, of the reagent rack, and is provided with an extraction liquid container guide hole, a quality control product container guide hole and a calibrator container guide hole; The lower limiting layer is arranged at the bottom of the reagent rack and is provided with lower limiting holes corresponding to the positions of the extraction liquid container guide holes, the quality control product container guide holes and the calibrator container guide holes respectively; The upper limit layer is arranged between the guide layer and the lower limit layer, and is provided with upper limit holes corresponding to the positions of the extraction liquid container guide holes, the quality control product container guide holes and the calibrator container guide holes respectively; the side wall accommodating groove is arranged on one side of the side wall of the reagent rack, which faces to the side wall of the box body.
  2. 2. The kit for detecting concentration of an anticoagulant in plasma according to claim 1, wherein the aperture of the guide hole of the extract container is larger than the aperture of the guide hole of the quality control material container; The aperture of the quality control product container guide hole is larger than that of the calibrator container guide hole.
  3. 3. The kit for detecting concentration of an anticoagulant in plasma according to claim 1, wherein labels are provided at positions near the extraction liquid container guide hole, the quality control material container guide hole, and the calibrator container guide hole.
  4. 4. The kit for detecting concentration of anticoagulant drugs in plasma according to claim 1, wherein the lower limiting layer is made of sponge, and the pore diameter of the lower limiting hole is smaller than the diameter of the corresponding container.
  5. 5. The kit for detecting the concentration of an anticoagulant drug in plasma according to claim 1, wherein the upper limit layer is made of a cardboard, the diameter of the upper limit hole is larger than the diameter of the corresponding container, and an elastic sheet extending from the hole wall to the center of the hole is formed in the circumferential direction of the upper limit hole.
  6. 6. The kit for detecting concentration of anticoagulant in blood plasma according to claim 1, wherein the number of the quality control material containers is plural, and the quality control material containers are respectively used for accommodating blank quality control materials and quality control materials with different concentrations.
  7. 7. The kit for detecting concentration of anticoagulant in blood plasma according to claim 1, wherein the plurality of calibrator containers are each configured to hold a plurality of calibrator at different concentrations.
  8. 8. The kit for detecting the concentration of an anticoagulant in plasma according to claim 1, wherein the case is provided with a cover.

Description

Kit for detecting concentration of anticoagulants in blood plasma Technical Field The utility model relates to the technical field of kits, in particular to a kit for detecting concentration of an anticoagulant drug in blood plasma. Background Anticoagulants refer to drugs that prevent blood coagulation by interfering with certain links of the physiological coagulation process of the body, and are mainly used to prevent thrombosis or the further development of formed thrombus. The anticoagulation medicine has the action mechanism that the coagulation effect is prevented from being amplified by reducing the level of coagulation factors or antagonistic factors in blood, the hypercoagulability state is relieved, fibrin embolus is avoided, and the key of successful anticoagulation treatment is that the physiological coagulation activation of organisms is effectively inhibited and simultaneously the physiological hemostatic capacity of organisms is maintained. Generally, the novel oral anticoagulants do not require conventional laboratory monitoring of pharmacokinetics (pharmacokinetics, PK) or pharmacodynamics (pharmacodynamics, PD) when treated at clinically fixed doses, but clinical studies indicate that drug monitoring is also necessary in certain special populations such as the elderly, those with weight abnormalities, those who need drugs that affect drug metabolizing enzymes, those with impaired renal function or those with adverse reactions. In addition, patients treated with the novel direct oral anticoagulants also need to be monitored in cases where special intervention or certain emergency situations (e.g., bleeding, acute stroke, trauma, surgery) are required, and their anticoagulation effect is assessed to guide subsequent treatment. The conventional detection method of the anticoagulation medicine mainly comprises enzyme-linked immunosorbent assay, chemiluminescence and HPLC, the immunological method often has cross reaction due to the problem of antibody specificity, the medicine concentration is estimated erroneously, the analysis result is wrong and possible clinical erroneous judgment is caused, and the measurement result of the liquid chromatography tandem mass spectrometry is the medicine concentration, so that the relation between the medicine concentration, the effect therapy and the adverse reaction can be more accurately described. Meanwhile, the LC-MS/MS has the advantages of short analysis time, rapid sample processing, strong specificity, high accuracy, high sensitivity, low cost and the like. LC-MS/MS technology has become a major means and trend in monitoring patient blood levels. In order to facilitate detection and simplify the detection process, a kit for detecting the concentration of an anticoagulant in plasma concentration needs to be developed. The reagent box in the prior art generally comprises a box body and an inner liner, wherein a reagent hole site is formed in the inner liner and is used for accommodating a container (or a reagent tube) filled with a solvent, the container (or the reagent tube) is placed on the top of the container (or the reagent tube), but the inner liner is generally positioned at the bottom of the reagent box, the thickness of the inner liner is less than 1/2 of the height of the reagent box, so that most of the container (or the reagent tube) is in an unfixed state, the container (or the reagent tube) is unstable in the transportation process, when in use, the container (or the reagent tube) needs to be taken out from the container (or the reagent tube) firstly and placed on an operating platform, or the container needs to be placed in the reagent box after being taken out from a table surface or a reagent rack of the operating platform singly, after the container is used, the container is placed in the reagent box after the container is separated from the reagent box, the container is easy to lose after the container is placed on the operating platform, the container is opened, the container is overturned, the solvent flows out after the container is mistakenly, and the reagent box is impossible to be put on the reagent rack, and the reagent rack needs to be additionally prepared. In addition, the containers may be confused during the process of taking out and replacing. Disclosure of utility model The utility model aims to solve the technical problem of providing a kit for detecting the concentration of an anticoagulant in blood plasma, which realizes the stability of a container in the transportation process, and the container does not need to be taken out independently when in use, so that the container is prevented from being knocked over or confused. In order to solve the technical problems, the kit for detecting the concentration of the anticoagulants in the blood plasma provided by the utility model comprises a kit body and a reagent rack arranged in the kit body, wherein the reagent rack is matched with the internal volume of the kit body