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CN-224231780-U - Reaction cup for in-vitro diagnostic equipment

CN224231780UCN 224231780 UCN224231780 UCN 224231780UCN-224231780-U

Abstract

The utility model discloses a reaction cup for in-vitro diagnostic equipment, which relates to the field of chemiluminescent immunoassay equipment and comprises an outer tube for collecting and an inner tube which is inserted into the outer tube and used for separating, wherein separating magnetic beads are arranged in the inner tube, a filter assembly is arranged at the bottom of the inner tube so that the separating magnetic beads in the inner tube cannot permeate the filter assembly, the outer tube and the inner tube both comprise a main body and two side lugs fixedly arranged on two sides of the top of the main body, and the two side lugs and the main body are arranged in a T shape. The filter assembly at the bottom of the inner tube ensures that the separation magnetic beads are blocked in the inner tube, and the liquid smoothly flows into the outer tube, so that the complexity and equipment dependence caused by the traditional centrifugal operation are avoided. In addition, the design can be seamlessly matched with the existing chemiluminescence immunoassay instrument, so that the detection efficiency and the automation degree are remarkably improved.

Inventors

  • LIU CHANG
  • SHI XIAOQIN
  • ZHANG KE
  • ZHANG WENXING
  • ZHANG LVPING
  • LIU GONGCHENG
  • WU XUEWEI
  • FU GUANGYU

Assignees

  • 郑州安图生物工程股份有限公司

Dates

Publication Date
20260512
Application Date
20250430

Claims (10)

  1. 1. A reaction cup for an in vitro diagnostic device, characterized by comprising an outer tube (1) for collection and an inner tube (2) inserted into the outer tube (1) and used for separation, wherein separation magnetic beads are arranged in the inner tube (2), and a filter assembly is arranged at the bottom of the inner tube (2) so that the separation magnetic beads in the inner tube (2) cannot permeate through the filter assembly; The outer tube (1) with the inner tube (2) all include the main part and fixed set up in two side ear of main part top both sides, two the side ear is the T style of calligraphy setting with the main part.
  2. 2. A reaction cup for an in vitro diagnostic device according to claim 1, wherein the filter assembly comprises a filter cloth (3) arranged at the bottom of the inner tube (2), a fixing assembly being arranged inside the inner tube (2) to fix the filter cloth (3) to the inner tube (2).
  3. 3. A reaction cup for an in vitro diagnostic device according to claim 2, wherein the fixation assembly comprises a clamping washer (4) arranged inside the inner tube (2), the clamping washer (4) being arranged along the inner wall of the bottom of the inner tube (2) to fix the filter cloth (3) to the inner tube (2).
  4. 4. A reaction cup for an in vitro diagnostic device according to claim 2, wherein the fixation assembly comprises a rubber ring arranged inside the inner tube (2) to fix the filter cloth (3) to the inner tube (2).
  5. 5. A reaction cup for an in vitro diagnostic device according to claim 1, wherein the filter assembly comprises a filter cloth (3) arranged at the bottom of the inner tube (2), the filter cloth (3) being glued to the inner wall of the inner tube (2).
  6. 6. A cuvette for an in vitro diagnostic device according to claim 1, characterized in that the filter assembly comprises a filter cartridge arranged at the bottom of the inner tube (2), which filter cartridge is fixedly connected to the inner tube (2).
  7. 7. A reaction cup for an in vitro diagnostic device according to any of claims 1 to 6, wherein a sealing spacer (5) is wound around the outside of the bottom of the inner tube (2), the side of the sealing spacer (5) remote from the inner tube (2) being in abutment with the inner wall of the outer tube (1).
  8. 8. A reaction cup for an in vitro diagnostic device according to claim 7, wherein a first baffle (6) is arranged on the side of the inner tube (2) outside the sealing spacer (5) facing away from the bottom of the outer tube (1), the first baffle (6) being in abutment with the sealing spacer (5).
  9. 9. A reaction cup for an in vitro diagnostic device according to claim 8, wherein a second baffle (7) is arranged outside the inner tube (2) on the other side of the sealing spacer (5), the first baffle (6) and the second baffle (7) clamping the sealing spacer (5) between.
  10. 10. The reaction cup for in-vitro diagnostic equipment according to claim 7, wherein the outer wall of the inner tube (2) is provided with a mounting groove (8), and the sealing spacer (5) is arranged in the mounting groove (8).

Description

Reaction cup for in-vitro diagnostic equipment Technical Field The utility model relates to the technical field of chemiluminescent immunoassay equipment, in particular to a reaction cup for in-vitro diagnostic equipment. Background Chemiluminescent immunoassay devices have been widely used in medical testing and related scientific analytical field studies. Based on the antigen-antibody specific recognition principle, the chemiluminescent immune reaction marks the antibody (antigen) on a solid medium such as magnetic particles and a tracer substance respectively, captures and traces the antigen (antibody) to be detected, and quantifies the substance to be detected by reading the chemiluminescent value excited by the tracer substance. The full-automatic chemiluminescence immunoassay analyzer is an important instrument for completing chemiluminescence immunoassay, and works such as quantitative addition, uniform mixing, incubation, magnetic attraction, washing, reading and signal value conversion of a reaction cup, a sample and a reagent in the detection process are realized through automatic mechanical equipment. However, in practical applications, an immune detection system often contains hundreds of items, and not all substances to be detected can be directly captured and tracked through antigen-antibody reaction. In particular, for some detection substances with too low protein abundance and complex protein composition in body fluid, the detection substances can exist in the elution supernatant only by means of extraction, impurity removal and elution treatment by functional extraction magnetic beads, so that conventional chemiluminescence immunoassay can be performed. However, in this process, the operation of extracting the supernatant and transferring to a new sample cup has a major conflict with the existing automatic operation procedure of the immunoassay analyzer, so that the detection flux of the immunoassay analyzer is seriously affected, and the detection efficiency is reduced. In the prior art, although some design attempts of the reaction cup are made to solve the problem, most of the prior art have limitations. For example, some reaction cups do not involve the function of separating magnetic beads from supernatant liquid although improving the stability of the sample cups in the process of grabbing and transferring the sample cups in an immunoassay analyzer, while other schemes capable of realizing the separation function, such as a pre-loaded centrifugal column, often require centrifugal separation, have complex operation, cannot be adapted to the existing chemiluminescent immunoassay analyzer, and cannot realize full-automatic high-throughput detection. In summary, how to provide a reaction cup which can not only effectively separate magnetic beads from supernatant, but also adapt to the existing chemiluminescence immunoassay instrument and realize full-automatic high-throughput detection is a problem to be solved by those skilled in the art. Disclosure of utility model In view of the above, the utility model aims to provide a reaction cup for in-vitro diagnostic equipment, which effectively separates magnetic beads from supernatant, can be well adapted to the existing chemiluminescence immunoassay instrument and realizes full-automatic high-flux detection. In order to achieve the above object, the present utility model provides the following technical solutions: the reaction cup for the in-vitro diagnostic equipment comprises an outer tube for collecting and an inner tube which is inserted into the outer tube and used for separating, wherein separation magnetic beads are arranged in the inner tube, and a filter assembly is arranged at the bottom of the inner tube so that the separation magnetic beads in the inner tube cannot permeate through the filter assembly; The outer tube with the inner tube all include the main part with fixed set up in two side ear of main part top both sides, two the side ear is T style of calligraphy setting with the main part. Preferably, the filter assembly comprises a filter cloth arranged at the bottom of the inner tube, and a fixing assembly is arranged in the inner tube so that the filter cloth is fixed on the inner tube. Preferably, the fixing component comprises a clamping washer arranged in the inner tube, and the clamping washer is arranged along the inner wall of the bottom of the inner tube so as to fix the filter cloth on the inner tube. Preferably, the fixing component comprises a rubber ring arranged in the inner tube so as to fix the filter cloth on the inner tube. Preferably, the filter assembly comprises a filter cloth arranged at the bottom of the inner tube, and the filter cloth is adhered to the inner wall of the inner tube. Preferably, the filter assembly comprises a filter element arranged at the bottom of the inner tube, and the filter element is fixedly connected with the inner tube. Preferably, a sealing spacer is wound outside the bottom