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CN-224232643-U - Chemical ionization source device based on thermal desorption

CN224232643UCN 224232643 UCN224232643 UCN 224232643UCN-224232643-U

Abstract

The utility model provides a chemical ionization source device based on thermal desorption, and belongs to the technical field of mass spectrometry devices. The device comprises a thermal desorption source, a triaxial moving platform, an analysis plate and an atmospheric pressure ion source, wherein a through hole is formed in the triaxial moving platform, the analysis plate is placed above the triaxial moving platform, a plurality of analysis holes are formed in the analysis plate, at least one analysis hole is aligned with the through hole, a metal alloy supporting plate for placing a sample is arranged in the analysis hole, the thermal desorption source is arranged below the through hole and faces the metal alloy supporting plate, a transmission pipe for inputting gas is arranged at an input port of the atmospheric pressure ion source, the front end of the transmission pipe can be inserted into and cover the analysis holes, and an output end of the atmospheric pressure ion source is used for being connected with a mass spectrometer. The chemical ionization source device based on thermal desorption is simple to operate, can ionize samples more efficiently, and therefore the plasma obtaining efficiency is improved, and the practicability is good.

Inventors

  • YU CHENGCHENG
  • ZHANG TAO
  • XIONG LIANG
  • WANG QIANGQIANG
  • LI YANMING

Assignees

  • 苏博泰克(北京)科学仪器有限公司

Dates

Publication Date
20260512
Application Date
20250611

Claims (9)

  1. 1. Chemical ionization source device based on thermal desorption, a serial communication port, including thermal desorption source (1), triaxial moving platform (2), analysis board (3), atmospheric pressure ion source (4), through-hole (2 a) have been seted up on triaxial moving platform (2), analysis board (3) are placed in triaxial moving platform (2) top, a plurality of analysis holes (3 a) have been seted up on analysis board (3), one of them analysis hole (3 a) with through-hole (2 a) are aligned, install in analysis hole (3 a) and be used for placing metal alloy layer board (3 b) of sample (8), thermal desorption source (1) set up through-hole (2 a) below and orientation metal alloy layer board (3 b), the input port of atmospheric pressure ion source (4) is equipped with transmission pipe (5) that are used for the input gas, transmission pipe (5) front end insertible and cover analysis hole (3 a), the output of atmospheric pressure ion source (4) is used for connecting the mass spectrometer.
  2. 2. A chemical ionization source device based on thermal desorption according to claim 1, characterized in that the atmospheric pressure ion source (4) comprises an ionization chamber (4 a), the rear end of the transmission tube (5) is inserted into the ionization chamber (4 a), and an ionization device (7) capable of ionizing the gas conveyed by the transmission tube (5) is arranged in the ionization chamber (4 a).
  3. 3. A chemical ionization source device based on thermal desorption according to claim 2, wherein the ionization device (7) is an APCI discharge needle arranged at the rear end port of the transfer tube (5).
  4. 4. A chemical ionization source device based on thermal desorption according to claim 2, characterized in that the ionization device (7) is a dielectric barrier discharge device mounted on the outer wall of the rear end of the transfer tube (5).
  5. 5. The chemical ionization source device based on thermal desorption according to any one of claims 1 to 4, wherein the front end of the transmission tube (5) comprises an outer tube (5 a) and an inner tube (5 b), the upper end of the outer tube (5 a) is in sealing connection with the outer wall of the inner tube (5 b), a downward opening and annular gap (5 c) is formed between the outer tube (5 a) and the inner tube (5 b), and a carrier gas tube (5 d) is inserted on the tube wall of the outer tube (5 a), and the carrier gas tube (5 d) is communicated with the gap (5 c).
  6. 6. A chemical ionization source device based on thermal desorption according to claim 5, wherein the inner tube (5 b) protrudes downwards relative to the outer tube (5 a).
  7. 7. A chemical ionization source device based on thermal desorption according to any one of claims 1-4, wherein the metal alloy pallet (3 b) is of a downwardly concave spherical structure.
  8. 8. A chemical ionization source device based on thermal desorption according to claim 7, wherein the metal alloy pallet (3 b) is a stainless steel plate.
  9. 9. A chemical ionization source device based on thermal desorption according to any one of claims 1-4, wherein the thermal desorption source (1) is a laser diode which emits infrared laser light of 760-1000 nm.

Description

Chemical ionization source device based on thermal desorption Technical Field The utility model belongs to the technical field of mass spectrometry devices, and particularly relates to a chemical ionization source device based on thermal desorption. Background Whether to develop new drugs for treating certain diseases such as cancer, obesity, etc., or to analyze drugs in blood, plasma, urine, or to detect trace pesticides in environmental samples, the need to increase the efficiency and speed of sampling and analysis has been an important issue. The laser melting ionization technology can directly analyze and measure solid/liquid samples, has the advantages of convenience and sensitivity, and is particularly suitable for surface element analysis and imaging. The principle of laser melting ionization mass spectrometry is to utilize plasma generated on the surface of high-power laser gas melting, and obtain chemical information by analyzing and detecting the ionic mass-to-charge ratio in the plasma. However, with the improvement of the productivity of pharmaceutical industry, environmental protection, food processing and the like, and the enrichment of product types, more analysis amount and more frequent analysis are required, which puts higher demands on the efficiency of the analysis device. However, conventional analytical techniques, such as liquid chromatography and gas chromatography, have some limitations that greatly prevent the achievement of the above-described objective of improving productivity. For example, sample preparation time, chromatographic system optimization time, risk of cross-contamination and "sample residue" affecting accuracy and reproducibility of results, high maintenance costs, and long analysis time are all one of the major limitations that conventional chromatographic techniques such as LC-MS, GC-MS, etc. inevitably encounter during use by users. Disclosure of Invention Aiming at the problems existing in the background technology, the utility model aims to provide a chemical ionization source device based on thermal desorption, which can eliminate chromatographic separation steps and greatly improve ionization efficiency. The chemical ionization source device based on thermal desorption is characterized by comprising a thermal desorption source, a triaxial moving platform, an analysis plate and an atmospheric pressure ion source, wherein a through hole is formed in the triaxial moving platform, the analysis plate is placed above the triaxial moving platform, a plurality of analysis holes are formed in the analysis plate, at least one analysis hole is aligned with the through hole, a metal alloy supporting plate for placing a sample is arranged in the analysis hole, the thermal desorption source is arranged below the through hole and faces the metal alloy supporting plate, a transmission pipe for inputting gas is arranged at an input port of the atmospheric pressure ion source, the front end of the transmission pipe can be inserted into and cover the analysis hole, and the output end of the atmospheric pressure ion source is used for being connected with a mass spectrometer. Preferably, the atmospheric pressure ion source comprises an ionization cavity, the rear end of the transmission pipe is inserted into the ionization cavity, and an ionization device capable of ionizing the gas conveyed by the transmission pipe is arranged in the ionization cavity. Preferably, the ionization device is an APCI discharge needle, and the APCI discharge needle is arranged at the rear end port of the transmission tube. Preferably, the ionization device is a dielectric barrier discharge device, and the dielectric barrier discharge device is mounted on the outer wall of the rear end of the transmission tube. Preferably, the front end of the transmission pipe comprises an outer pipe and an inner pipe, the upper end of the outer pipe is in sealing connection with the outer wall of the inner pipe, a downward opening annular gap is formed between the outer pipe and the inner pipe, a gas carrying pipe is inserted into the pipe wall of the outer pipe, and the gas carrying pipe is communicated with the gap. Preferably, the inner tube protrudes downwardly relative to the outer tube. Preferably, the metal alloy supporting plate is of a spherical structure which is concave downwards. By this structural design, the analyte or sample droplets that crystallize upon evaporation of the solvent can be concentrated in a central region. Preferably, the metal alloy pallet is a stainless steel plate. Preferably, the thermal desorption source is a laser diode, and the laser diode emits 760-1000nm infrared laser. Compared with the prior art, the utility model has the advantages that the chromatographic separation step is eliminated by combining the thermal desorption of the laser diode and the atmospheric pressure chemical ionization technology, the analysis time is obviously shortened, the ionization efficiency is gre