DE-102010036193-B4 - Device for contactless transmission of electrical energy for bioreactor components

Abstract

Device for contactless transmission of electrical energy with a transmission component and a receiver component, wherein at least one component of a bioreactor can be supplied with electrical energy on an inductive basis, the transmission component is located outside the bioreactor, and the receiver component is located inside the bioreactor.

Inventors

• Daniel Süß

Assignees

• SARTORIUS STEDIM BIOTECH GMBH

Dates

Publication Date

20260513

Application Date

20100902

Claims (7)

1. Device for contactless transmission of electrical energy with a transmission component and a receiver component, wherein at least one component of a bioreactor can be supplied with electrical energy on an inductive basis, wherein the transmission component is placed outside the bioreactor, and the receiver component is located inside the bioreactor.
2. Device for contactless transmission of electrical energy according to Claim 1 , wherein at least one component is located within the bioreactor.
3. Device for contactless transmission of electrical energy according to one of the preceding claims, wherein the bioreactor is designed as a disposable bioreactor made of flexible plastic.
4. Device for contactless transmission of electrical energy according to one of the preceding claims, wherein the at least one component is a sensor device, a drive for a mixer shaft, a valve, a port system or a gassing device.
5. Device for contactless transmission of electrical energy according to Claim 4 , wherein the component is a drive for a mixer shaft and the mixer shaft can be set in rotation.
6. Device for contactless transmission of electrical energy according to one of the preceding claims, wherein the transmission component is an induction coil and the receiver component is an induced coil.
7. Device for contactless transmission of electrical energy according to one of the preceding claims, wherein the receiver component comprises an accumulator.

Description

The invention relates to a device that supplies energy to energy-requiring components of a bioreactor without physical contact. Such a device is used in particular in disposable, mixed, and bioreactors in the pharmaceutical, chemical, biotechnological, or food industries. Maintaining sterility is an important feature for disposable, mixed and bioreactors used by the pharmaceutical, chemical, biotechnological or food industries in order to conduct safe production or research. From the DE 19 726 840 A1 A device for contactless electrical energy transmission is known, comprising a power source with an induction coil to which electrical energy is supplied, and a plurality of powered sources, each with an induced coil arranged in a magnetic field generated by the induction coil. The powered sources differ in their load, with each of the powered sources having a section for adapting the electrical energy according to the individual power source in order to receive electrical energy from the power source in response to the load. The individual power source is used, with only the powered sources taking the load difference into account. From the DE 10 2008 010 427 B4 A bioreactor is known comprising a vessel, a shaft housing for passing a shaft through a wall, an agitator connected to the shaft inside the vessel, and a drive unit connected to the shaft located outside the vessel. The shaft is supported in the shaft housing by at least one ball bearing and sealed against the shaft housing by at least one seal. The seal is characterized in that it is a radial shaft seal with two sealing lips arranged one behind the other in the longitudinal direction of the shaft and capable of running dry on the shaft. The radial shaft seal has a closed end face facing the interior of the vessel, which transitions radially into a sealing lip designed as a protective lip. The radial shaft seal also has a sealing lip facing the external drive unit, which is pressed against the shaft surface by a spring ring. A disadvantage of this design is that the drive motor for the agitator shaft, located outside the bioreactor, necessitates an opening in the bioreactor for the agitator shaft. Therefore, sterility is not completely guaranteed due to, for example, design flaws or faulty seals. From the DE 10 2008 025 507.6 A1 A bioreactor is known in which the drive mechanism does not compromise the sterility of the interior of the disposable container. This is achieved through a mixing system consisting of a disposable container with flexible walls and a mixing device that incorporates an encapsulated drive and a mixing shaft within the bioreactor. A disadvantage of the drive motor being located inside the bioreactor is that it can be subject to thermal or similar influences, such as when the motor heats up and thus affects the medium within the bioreactor. Damage to the motor is also conceivable if high temperatures or humidity levels prevail within the bioreactor. The DE 10 2009 056 468 A1 describes a stirring device for a milliliter bioreactor with at least one planar stirring paddle, as well as with an axis arrangement device which is designed such that the stirring device can be arranged on an axis of rotation via the axis arrangement device in such a way that the axis of rotation runs parallel to the surface of the stirring paddle, wherein the stirring device is designed relative to the milliliter bioreactor in such a way that a liquid lamella can be generated with it in the milliliter bioreactor. The DE 10 2006 018 824 A1 This describes a reactor driven by oscillation around its stationary, preferably vertical, axis, primarily for biotechnological and pharmaceutical applications. Its process-enhancing properties for mixing, suspension, gas transport, heat transfer, irradiation, and particle retention ensure its suitability for large-scale industrial applications. The reactor, which requires no shaft seal, allows for particularly robust sterile production without the need for cleaning and cleaning validation when designed as a single-use reactor. The DE 603 18 593 T2 Describes a method for producing chaotic mixing affecting the entire volume of a liquid in a container, comprising: inserting a magnetic stir bar into the container so that it is generally vertically oriented, the stir bar having a length greater than an inner diameter of the container or half the depth to more than the depth of the liquid in the container; generating an irregular stirring pattern of the stir bar in the liquid by actuating at least two fixed magnetic drives to create at least one to activate a magnetic field, whereby the magnetic field causes the stirring rod to move in an irregular stirring pattern. The DE 102 60 691 A1 This describes a device for cultivating cells in liquid columns on a milliliter scale, comprising a container for holding a liquid cell culture suspension and an agitator for stirring the culture suspension in the container around a stirring axis