DE-102024132942-A1 - Hair and scalp treatment products

Abstract

Cosmetic products containing specific amounts of adenosine and at least one pentose in a cosmetic carrier are suitable for the treatment of hair and/or scalp and lead to - Revitalization of the hair and/or - Stimulation/activation of energy metabolism in hair follicles/hair roots and/or - Stimulation/enhancement of hair growth and/or - Prevention/reduction of premature hair loss and/or - Delaying scalp aging and/or - Increased keratin synthesis and/or - Improvement of the tensile strength of keratin fibers.

Inventors

• Thomas Welss
• Sabine Gruedl

Assignees

• HENKEL AG & CO. KGAA

Dates

Publication Date

20260513

Application Date

20241112

Claims (10)

1. Cosmetic product for the treatment of hair and/or scalp, containing in a cosmetic carrier a) 0.05 - 3 wt% adenosine and b) 0.05 - 5 wt% at least one pentose, the quantities referring to the total weight of the cosmetic product.
2. Cosmetic product after Claim 1 , wherein the pentose is selected from (deoxy)ribose, (deoxy)arabinose, (deoxy)xylose, (deoxy)lyxose, (deoxy)ribulose, (deoxy)xylulose or mixtures thereof.
3. Cosmetic product based on one of the Claims 1 or 2 containing 2-deoxy-β-D-ribose.
4. Cosmetic product based on one of the Claims 1 until 3 in the form of a solid or liquid cleansing composition for hair and/or scalp, containing at least one surfactant selected from anionic, amphoteric, zwitterionic, non-ionic surfactants or mixtures thereof in a weight fraction of 0.1 - 60% by weight of the total weight of the cosmetic product.
5. Cosmetic product based on one of the Claims 1 until 3 in the form of a solid or liquid leave-in or rinse-off care composition for hair and/or scalp, containing at least one cationic surfactant in a weight fraction of 0.1 - 35% by weight of the total weight of the cosmetic product.
6. Cosmetic product according to any of the preceding claims in the form of a cream, emulsion, PIT emulsion, dispersion, solution, gel, spray or oil.
7. Cosmetic product according to one of the preceding claims, comprising water as a cosmetic carrier in a weight fraction of 10 - 98 wt.% of the total weight of the cosmetic product.
8. Cosmetic composition according to any of the preceding claims, comprising at least one C2-C10 alcohol comprising one or more hydroxyl groups, in a weight fraction of 0.05 - 70 wt.% of the total weight of the cosmetic composition.
9. A cosmetic composition according to any of the preceding claims, comprising at least one bioactive ingredient in a weight fraction of 0.01–30% by weight of the total weight of the cosmetic composition, selected from urea and/or its derivatives, L-carnitine and/or its salts and/or derivatives; taurine, vitamins, ubiquinone (coenzyme Q10), allantoin; plant extracts, xanthines, in particular caffeine, flavonoids, in particular flavonols; bisabolol; creatine, amino acids and/or salts and/or derivatives of amino acids and/or mixtures thereof.
10. Use of a cosmetic product containing in a cosmetic carrier - each based on its weight - a) 0.05 - 3 wt% adenosine and b) 0.05 - 5 wt% at least one pentose, for: - revitalizing hair and/or - stimulating/activating energy metabolism in hair follicles/hair roots and/or - stimulating/enhancing hair growth and/or - preventing/reducing premature hair loss and/or - delaying scalp aging and/or - increasing keratin synthesis and/or - improving the tensile strength of keratin fibers.

Description

The present invention relates to cosmetic agents for the treatment of hair and/or scalp, based on a combination of adenosine and at least one pentose, and to the cosmetic use of the agents. Androgenetic alopecia is a widespread phenomenon and often affects the self-esteem of those who suffer from it. Hair follicle cells are subject to a genetically determined cycle of growth, regression, and resting phases. The hair follicle is thus the only organ that constantly renews itself and therefore exhibits a unique metabolism depending on the respective growth phase. The synthesis of the structural keratins is also linked to this cycle. This cycle is controlled by a small, highly specialized cell population in the hair bulb, the dermal papilla cells, which regulate hair growth through a unique, complex system of molecular signals specific to each phase of the hair cycle. If the metabolism of these highly specialized cells is to be modulated by applying a test formulation, it is essential to specifically target the relevant mechanisms. Maintaining or rejuvenating hair through suitable active ingredient formulations is a challenge for cosmetic research. Topical applications for treating hair structure disorders, such as split ends or breakage, typically involve physical methods in which polymers or structural proteins are applied to the hair. The long-term effects of these methods are limited, and there is also the risk of overloading the hair with conditioning substances through repeated application. Furthermore, the only way to structurally improve hair from the root is usually through oral administration of certain active ingredients. Investigations into the molecular and cell physiological reasons for phenotypic changes during the aging process have shown that, among other things, the synthesis of the structure-giving hair keratins in the aging hair follicle decreases significantly, which is one of the causes of androgenetic alopecia. In particular, the hair keratins KRT86 (hhb6), KRT34 (hha4) and KRT33a (hha3) as well as various cytokeratins (e.g. CK1) are affected by age-related changes. Hair keratins represent the most important structural component of hair. The importance of hair keratins for a healthy hair fiber is demonstrated by the fact that genetic mutations in hair keratins can lead to significant changes, such as deformation and breakage of the hair fiber (monilethix). There are hardly any cosmetic products on the market that can support the synthesis of hair-specific keratins in a biological and therefore sustainable way. The aim of the present invention was to find suitable active ingredients for cosmetic hair and/or scalp treatment products that can be applied topically to the hair and/or scalp, protect against premature hair loss, activate keratin synthesis, and thus counteract hair aging. Furthermore, the condition of the scalp should be improved, which in particular means that the scalp is soothed and its elasticity is improved. Ideally, the active ingredients should be able to be incorporated into a wide variety of cosmetic products in order to offer consumers a broad range of application options. These goals were largely achieved through the combination of adenosine, pentose(s) and a suitable carrier in cosmetic products. A first object of the invention is therefore a cosmetic agent for the treatment of hair and/or scalp, which is contained in a cosmetic carrier. a) 0.05 - 3 wt% adenosine and b) Contains 0.05 - 5 wt% of at least one pentose, where the quantities refer to the total weight of the cosmetic product. In particular, the combination of active ingredients a) and b) enables the development of new product and action concepts for biologically active hair and/or scalp treatment products that counteract or reverse the decline in keratin synthesis, the decrease in cell division activity and the decline in cell vitality. In addition, the combination of active ingredients a) and b) improves hair volume (which becomes thicker again through increased keratin synthesis) as well as the feel and combability of treated hair. The combination of active ingredients a) and b) in cosmetic hair treatment products further counteracts or reverses increased microinflammation and apoptosis. Preferred cosmetic products according to the present invention are characterized in that they particularly stimulate the synthesis of the aging-affected hair keratins KRT86 (hhb6), KRT34 (hha4) and KRT33a (hha3). A preferred embodiment of the use according to the invention is characterized in that cell vitality, cell proliferation and the release of growth factors are stimulated, thus positively influencing the anagen hair growth phase and inhibiting the activation of catagen-associated parameters. The compositions according to the invention contain adenosine in an amount of 0.05 to 3 wt.%. Adenosine is a nucleoside and consists of the nucleobase adenine and the sugar β-D-ribose. Preferred compositions contain adenosine i