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EP-3355853-B1 - ARTIFICIAL SWEAT COMPOSITION

EP3355853B1EP 3355853 B1EP3355853 B1EP 3355853B1EP-3355853-B1

Inventors

  • SINGER, Marco
  • MCDERMOTT, KEITH
  • OLALDE-CASTILLO, Marcela
  • PRETI, GEORGE
  • WYSOCKI, CHARLES
  • PRIGGE, Katherine Ashley

Dates

Publication Date
20260506
Application Date
20151022

Claims (13)

  1. An artificial sweat odour composition comprising (i) from 0.0005 to 0.1 % by weight alkenoic acid compound which is 3-methyl-2-hexenoic acid, and (ii) from 0.0001 to 0.2 % by weight saturated aliphatic carboxylic acid compound which is a mixture of 4-ethyl octanoic acid, butyric acid, hexanoic acid, isovaleric acis, nonanoic acid and octanoic acid, acetic acid and propionic acid, and (iii) from 0.1 to 2.0 % by weight saturated aliphatic hydroxyl carboxylic acid compound which is lactic acid, each based on the total weight of the total composition, wherein the total weight of all compounds in the artificial sweat odour composition is less than 3 % by weight.
  2. An artificial sweat odour composition comprising (i) from 0.1 to 0.2 % by weight alkenoic acid compound which is a mixture of 3-methyl-2-hexenoic acid and 7-octenoic acid, and (ii) from 0.2 to 0.3 % by weight saturated aliphatic carboxylic acid compound which is a mixture of isovaleric acid, 2-methyl butyric acid, hexanoic acid, octanoic acid, nonanoic acid, 4-ethyl octanoic acid, decanoic acid, undecanoic acid, butyric acid, and (iii) from 0.04 to 0.1 % by weight saturated aliphatic hydroxyl carboxylic acid compound which is 3-hydroxy-3-methylhexanoic acid, and (iv) from 0.00001 to 0.0001 % by weight mercapto-alkanol compound which is a mixture of 3-mercapto-1-hexanol, 3-mercapto-3-methyl-1-hexanol, each based on the total weight of the total composition, wherein the total weight of all compounds in the artificial sweat odour composition is less than 3 % by weight.
  3. An artificial sweat odour composition comprising (i) from 0.1 to 0.7 % by weight alkenoic acid compound which is a mixture of 3-methyl-2-hexenoic acid and 7-octenoic acid, and (ii) from 0.2 to 0.5 % by weight saturated aliphatic carboxylic acid compound which is a mixture of isovaleric acid, 2-methyl butyric acid, hexanoic acid, octanoic acid, nonanoic acid, 4-ethyl octanoic acid, decanoic acid, undecanoic acid, butyric acid, and (iii) from 0.003 to 0.01 % by weight saturated aliphatic hydroxyl carboxylic acid compound which is 3-hydroxy-3-methylhexanoic acid, and (iv) from 0.000008 to 0.0001 % by weight mercapto-alkanol compound which is a mixture of 3-mercapto-1-hexanol, 3-mercapto-3-methyl-1-hexanol, each based on the total weight of the total composition, wherein the total weight of all compounds in the artificial sweat odour composition is less than 3 % by weight.
  4. The composition of Claim 1 to 3, wherein the composition further comprises a solvent, wherein the solvent is selected from trialkyl citrates such as triethylcitrat (TEC), trimethyl citrate, tripropyl citrate, tri-isopropyl citrate, tributyl citrate, tri-isobutyl citrate, tri- sec.-butyl citrate, dialkylphthalates such as dimethylphtahalat, diethylphtalat (DEP), dibutylphthalat, benzylbenzoat, isopropylmyristate, dioctyladipat, alcohols such as 1,2-alkandiols such as 1,2-butadiol, 1,2-pentandiol, 1,2-hexandiol, 1,2-heptanddiol, 1,2-octandiol, 1,2-nonandiol, 1,2-decandiol, 1,2-undecandiol, 1,2,dodecandiol, ethanol, fatty oils, such as cooking oils and in particular vegetable oils such as for example borage oil, thistle oil, groundnut oil, hazelnut oil, coconut oil, pumpkin seed oil, linseed oil, maize germ oil, macadamia nut oil, almond oil, olive oil, pecan nut oil, pistachio kernel oil, rapeseed oil, rice germ oil, sesame seed oil, Soya oil, sunflower oil, walnut oil or wheat germ oil, fractionated coconut oils, which mainly have fatty acid residues with a length of between six and eight carbon atoms (C6- to C8-fatty acids), propylene glycol, diacetine (glycerine diacetate), triacetine (glycerine triacetat), benzyl alcohol, triethyl citrate, ethyl lactate, isopropanol and glycerine, mineral oil and mixtures thereof.
  5. The use of the artificial sweat odour composition of Claim 1 to 3 as a malodour standard.
  6. The use of the artificial sweat odour composition of Claim 1 to 3 for evaluating an effect of masking, harmonizing or deodorizing the odour of sweat.
  7. A scent /smell pen or spray comprising the artificial sweat odour composition of Claim 1, Claim 2 or Claim 3.
  8. The use of a scent /smell pen or spray according to claim 7 as a malodour standard for training a sensory panel group.
  9. A method for evaluating an effect of masking, harmonizing or deodorizing to a body odour by a sample comprising one or more flavors or fragrances, comprising the steps: (a) providing an artificial sweat odour composition according to any claims 1 to 4, (b) bringing the artificial sweat odour composition of step a) in contact with the flavour or fragrance sample which is to be evaluated, (c) determining the intensity and/or malodour impression of the artificial sweat odour composition in comparison to the flavor or fragrance sample which is to be evaluated.
  10. A method of evaluating a masking, harmonizing or deodorizing effect to a sweat odour using the artificial sweat odour composition of Claim 1, Claim 2 or Claim 3.
  11. Artificial sweat composition comprising Name (all amounts in wt.-percent) I Isovaleric acid 0,02 2-Methyl butyric acid 0,07 Caproic acid 0,01 3-Methyl-2-hexenoic acid 0,55 Octanoic acid 0,07 Nonanoic acid 0,02 4-Ethyl octanoic acid 0,06 Decanoic acid 0,02 3-Hydroxy-3-methylhexanoic acid 0,005 3-Mercapto-3-methyl-1-hexanol 0,000005 Undecanoic acid 0,01 Butyric acid 0,002 3-Mercapto-1-hexanol 0,000005 7-Octenoic acid 0,05
  12. Artificial sweat composition comprising Name (all amounts in wt.-percent) I Isovaleric acid 0,04 2-Methyl butyric acid 0,04 Caproic acid 0,06 3-Methyl-2-hexenoic acid 0,1 Octanoic acid 0,04 Nonanoic acid 0,04 4-Ethyl octanoic acid 0,02 Decanoic acid 0,04 3-Hydroxy-3-methylhexanoic acid 0,06 3-Mercapto-3-methyl-1-hexanol 0,00001 Undecanoic acid 0,02 Butyric acid 0,009 3-Mercapto-1-hexanol 0,00001 7-Octenoic acid 0,05
  13. Artificial sweat composition comprising Name (all amounts in wt.-percent) I Isovaleric acid 0,001 Caproic acid 0,01 3-Methyl-2-hexenoic acid 0,01 Octanoic acid 0,3 Nonanoic acid 0,12 4-Ethyl octanoic acid 0,2 Decanoic acid 0,06 Butyric acid 0,002 Lactic acid 1 Propionic acid 0,002 Acetic acid 0,001

Description

FIELD OF THE INVENTION The present invention belongs to the area of body odour modelling. In particular, the developed synthetic compositions of the present invention reconstitute human body odours, especially those arising from axillary perspiration. The use of said compositions allows for the evaluation of malodour masking effects of fragrant compositions in the field of personal care or homecare products and cosmetic product development. STATE OF THE ART Fragranced products such as perfumes, deodorants or other fragrance containing personal care or cosmetic products have widely been used to mask unpleasant body odours, in particular the malodour of human sweat. Developing particularly efficient fragrance compositions that are able to overcome bad odours from axillary perspiration is a major challenge. Until now this development heavily relies on expensive and time consuming in vivo studies requiring human test subjects and therefore does not allow for systematic and extensive screening of individual fragrance raw materials or perfume oils. Furthermore working with authentic sweat samples ex vivo is difficult since the odour quality and intensity of those samples changes, making reproducible and consistent measurement over an extended time period difficult. As a result artificially created malodours are of high interest to the field of malodour counteraction. Current approaches involve only single materials known to be present in human axillary secretions like 3-mercapto-3-methyl-hexan-1-ol or simple mixtures of 3-methyl-2-hexenoic acids and 3-hydroxy-3-methyl-hexanoic acid as malodour standards solely relying on analytic investigations of human sweat samples. WO 2004/078154 A1 discloses pseudo body odour compositions which are close to peculiar odour that an actual body has. The pseudo body odour composition therein, comprises (A) at least one kind selected from (A-1) hydroxyalkanyl carboxylic acids having 5 to 8 carbon atoms and (A-2) alkenyl carboxylic acids having 5 to 8 carbon atoms and one double bond; (B) at least one kind selected from fatty acids having 2 to 24 carbon atoms; and (C) at least one kind selected from aldehydes having 2 to 13 carbon atoms. Component (A-2) is selected from racemic 3-methyl-2-hexenoic acid. WO 2006/003053 A1 refers to the use of 3-mercapto-3-methyl-hexan-1-ol as malodour standard. The use of the said standard shall allow determination of particularly effective perspiration odour-masking fragrant compositions. JP2005062159 A discloses a pseudo-axillary composition containing 3-mercapto-3-methyl hexan-1-ol, 3-mercapto-2-methyl hexan-1-ol, 3-hydroxy-3-methyl hexanoic acid, acetic acid, propionic acid, isovaleric acid, butyric acid, isobutyric acid and mineral oil. EP1553411 A1 discloses an indicator material for assessing body odor comprising mixtures of 3-hydroxy-3-methylhexanoic acid and 3-mercapto-3-methylhexanol. There is therefore a demand for a malodour standard that is based on analytical data as well as sensory evaluation of human sweat extracts in order to closely match genuine human sweat in terms of chemical components and odour quality. In particular, the malodour standard should be chemically stable over an extended period of time in order to produce reproducible results. Furthermore, an object of the invention was to develop specific body odour models compositions which show certain characteristics of sweat odour for different ethnic groups. Especially, an object of the present invention was the development of body odour model compositions that can be used for body odour masking tests that take into account the ethnicity of the targeted consumer groups, thereby allowing a more focused and personalized product development. DESCRIPTION OF THE INVENTION Described herein are artificial sweat odour compositions, comprising a solvent and (i) at least an alkenoic acid compound having 2-10 carbon atoms,(ii) at least a saturated aliphatic carboxylic acid compound having 2-15 carbon atoms, and optionally(iii) at least one saturated aliphatic hydroxyl carboxylic acid compound having 3-10 carbon atoms, and/or(iv) at least one mercapto-alkanol compound having 2-10 carbon atoms, Surprisingly, analytical and sensory studies with human sweat samples from subjects differing in ethnicity showed distinct chemical compositions and odour profiles depending on the donor's ethnical background. It has been observed that artificial sweat odour compositions have to take into account these differences in order to reliably match and distinguish axillary odours of people from varying origin. Furthermore it has been shown that these new artificial compositions are easily reproducible and stable over time. Described herein are artificial sweat odour composition, wherein the compounds (i) to (iv) can be selected from (i) 7-octenoic acid, 3-methyl-2-hexenoic acid;(ii) isovaleric acid, 2-methyl butyric acid, hexanoic acid, octanoic acid, nonanoic acid, 4-ethyl octanoic acid, decanoic acid, u