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EP-3393382-B1 - AN OPHTHALMIC KNIFE

EP3393382B1EP 3393382 B1EP3393382 B1EP 3393382B1EP-3393382-B1

Inventors

  • KAHOOK, MALIK, Y.
  • MANSOUR, KHALID
  • ABDULLAH, Suhail
  • PORTEOUS, ERIC

Dates

Publication Date
20260506
Application Date
20161222

Claims (9)

  1. An ophthalmic knife, comprising: a shaft (3); a first platform (5) extending radially from a first radial side of the shaft; and a second platform (5); wherein each of the first and second platforms comprises: a ramp that increases from a first thickness at a distal side of the ramp to a second thickness, greater than the first thickness and at a proximal side of the ramp; and first (10, 14) and second (11, 15) blades that extend from the proximal side of the ramp to the shaft, wherein each of the first and second platforms comprises an anterior blade tip (6), characterized by the second platform (5) extending radially from a second radial side of the shaft, opposite the first radial side.
  2. The ophthalmic knife of Claim 1, wherein the shaft, the first platform, and the second platform define a single flat and continuous bottom surface that is opposite each of the first and second blades.
  3. The ophthalmic knife of Claims 1 or 2, wherein each ramp is wedge-shaped (38) for elevating a portion of a trabecular meshwork away from an outer wall of a Schlemm's canal.
  4. The ophthalmic knife of Claims 1 or 2, wherein each of the first and second platforms further comprises a top side and a bottom side, and the first thickness and the second thickness are each defined between the top side and the bottom side of the corresponding one of the first and second platforms.
  5. The ophthalmic knife of Claim 4, wherein the bottom side of the first platform is coplanar with the bottom side of the second platform.
  6. The ophthalmic knife of Claims 1 or 2, wherein each of the first and second platforms further comprises a first lateral side extending from the proximal side to the distal side and a second lateral side extending from the proximal side to the distal side.
  7. The ophthalmic knife of Claims 1 or 2, wherein a bottom side of each of the first and second platforms is aligned with a terminal end of the shaft defining a portion of the bottom surface.
  8. The ophthalmic knife of any of Claims 1 to 7, further comprising: a handle (1) connected to the shaft.
  9. The ophthalmic knife of Claim 8, wherein each of the first and second platforms is positioned at a fixed angle relative to the handle.

Description

FIELD OF THE INVENTION The present disclosure relates to an ophthalmic knife for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. An ophthalmic knife can be used for cutting the tissues within the eye, for example, a trabecular meshwork (TM). BACKGROUND OF THE INVENTION There are numerous medical and surgical procedures in which it is desirable to cut and remove a strip of tissue of controlled width from the body of a human or veterinary patient. For example, it may sometimes be desirable to form an incision of a controlled width (e.g., an incision that is wider than an incision made by a typical scalpel, cutting blade or needle) in the eye, skin, mucous membrane, tumor, organ or other tissue or a human or animal. In addition, it may sometimes be desirable to remove a strip or quantity of tissue from the body of a human or animal for use as a biopsy specimen, for chemical/biological analysis, for retention or archival of DNA identification purposes, etc. In addition, some surgical procedures require removal of a strip of tissue of a known width from an anatomical location within the body of a patient. One surgical procedure wherein a strip of tissue of a known width is removed from an anatomical location within the body of a patient is an ophthalmological procedure used to treat glaucoma. This ophthalmological procedure is sometimes referred to as a goniotomy. In a gonioctomy procedure, a device that is operative to cut or ablate a strip of tissue of approximately 2-10 mm in length or more and about 50-200 µπ in width is inserted into the anterior chamber of the eye and used to remove a full thickness strip of tissue from the trabecular meshwork. At present there remains a need in the art for the development of simple, inexpensive and accurate instruments useable to perform the procedure of cutting the trabecular meshwork (TM) in the eye and effectively remove a complete full thickness strip of TM without leaving TM leaflets as well as other procedures where it is desired to remove a strip of tissue from a larger mass of tissue. WO 2013/163034 A1 relates to a microsurgical device and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. WO 2013/163034 A1 specifically relates to a dual-blade device for cutting the trabecular meshwork (TM) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.3-.2 mm width) and configuration where the blade tip curves up providing a ramp-like action for cutting the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues. SUMMARY OF THE INVENTION The invention is set out in the appended claims. DEFINITIONS To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as "a", "an" and "the" are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims. As used herein, the term "patient" or "subject" refers to a living mammalian organism, such as a human, monkey, cow, sheep, goat, dog, cat, mouse, rat, guinea pig, or transgenic species thereof. In certain embodiments, the patient or subject is a primate. Non-limiting examples of human subjects are adults, juveniles, infants and fetuses. In interpreting the disclosure, all terms should be interpreted in the broadest possible manner consistent with the context. In particular, the terms "comprises" and "comprising" should be interpreted as referring to elements, components, or steps in a nonexclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced. "Prevention" or "preventing" includes: (1) inhibiting the onset of a disease in a subject or patient which may be at risk and/or predisposed to the disease but does not yet experience or display any or all of the pathology or symptomatology of the disease, and/or (2) slowing the onset of the pathology or symptomatology of a disease in a subject or patient which may be at risk and/or predisposed to the disease but does not yet experience or display any or all of the pathology or symptomatology of the disease. The term "therapeutically effective amounts" or "pharmaceutically effective amounts", as used herein means that amount which, when administered to a subject or patient for treating a disease, is sufficient