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EP-3459460-B1 - BLOOD INSPECTION SYSTEM AND BLOOD INSPECTION SYSTEM CONTROL METHOD

EP3459460B1EP 3459460 B1EP3459460 B1EP 3459460B1EP-3459460-B1

Inventors

  • TSUBOUCHI, TAKESHI

Dates

Publication Date
20260506
Application Date
20170419

Claims (7)

  1. A blood inspection system (10, 20) for inspecting blood, the blood inspection system (10, 20) comprising: a main flow path (121) through which a fluid including blood can circulate in operation of said system; a supply section (210) arranged to supply a cleaning liquid to the main flow path, said supply section (210) including a flushing liquid holding unit (212), and a supply pump (214); a plurality of inspection units (300, 500, 600) configured to perform a blood inspection; a plurality of bifurcated flow paths (131) which are bifurcated from the main flow path (121) and arranged to guide blood to the plurality of inspection units (300, 500, 600); an aspiration unit arranged to aspirate blood from a living body via the main flow path and guides the blood to the plurality of bifurcated flow paths; a discharge flow path (141, 741) which communicates with the main flow path (121) and arranged to discharge at least a part of the fluid from the main flow path (121) and/or the plurality of bifurcated flow paths (131); a switching unit (150) which is capable of selectively switching between a communication state of the main flow path (121) and the plurality of bifurcated flow paths (131) and a communication state of the main flow path (121) and the discharge flow path (141, 741); characterized by said aspiration unit including an aspiration pump (220), and by a control unit (400) configured to control an operation of each of the units of the system (10, 20), wherein the control unit (400) is configured to cause the main flow path (121) and one bifurcated flow path of the plurality of bifurcated flow paths (131) to communicate with each other when the plurality of inspection units (300, 500, 600) perform a blood inspection, such that blood is guided to one inspection unit of the plurality of inspection units (300, 500, 600), which has not yet performed an inspection of blood.
  2. The blood inspection system (10, 20) according to Claim 1, wherein the discharge flow path (141) is bifurcated from the main flow path (121), and wherein the switching unit (150) is configured to perform switching such that the main flow path (121) is in a state of communicating with one bifurcated flow path of the plurality of bifurcated flow paths (131) or the discharge flow path (141).
  3. The blood inspection system (10, 20) according to Claim 1 or 2, further comprising: a sensor (S) which is arranged to measure a concentration of blood within the fluid disposed inside the main flow path (121).
  4. The blood inspection system (10, 20) according to any one of Claims 1 to 3, wherein the plurality of inspection units (300, 500, 600) each include a clotting time measuring instrument (310, 510) that is configured to measure a clotting time of blood respectively guided from the plurality of bifurcated flow paths (131).
  5. The blood inspection system (10, 20) according to Claim 4, wherein the clotting time measuring instrument (310, 510) is a viscosity measuring module that is configured to measure the clotting time by measuring a viscosity of blood mixed with a clotting accelerator or a flow measuring module that is configured to measure the clotting time by measuring flow characteristics of blood inside a canaliculus in which the clotting accelerator is disposed.
  6. The blood inspection system (10, 20) according to any one of Claims 1 to 5, wherein the plurality of inspection units (300, 500, 600) each include a blood glucose level measuring instrument (610) that is configured to measure a glucose level of blood guided from the plurality of bifurcated flow paths (131).
  7. A control method for a blood inspection system according to any of the preceding claims controlling a supply section which supplies a cleaning liquid to a main flow path, a plurality of inspection units which perform a blood inspection, an aspiration unit which guides blood collected from a living body to a plurality of bifurcated flow paths bifurcated from the main flow path, and a switching unit which is capable of switching between a communication state of the main flow path and the plurality of bifurcated flow paths and a communication state of the main flow path and a discharge flow path capable of discharging a fluid, the control method comprising: a cleaning step of cleaning an inside of the main flow path by discharging fluid from the main flow path while supplying the cleaning liquid to the main flow path; a first inspecting step of inspecting the collected blood using one inspection unit of the plurality of inspection units by causing the main flow path and one bifurcated flow path of the plurality of bifurcated flow paths to communicate with each other; and a subsequent inspecting step of inspecting the collected blood using another inspection unit of the plurality of inspection units, which has not yet performed an inspection.

Description

Technical Field The present invention relates to a blood inspection system and a control method for a blood inspection system. Background Art In the related art, treatment has been performed by a percutaneous cardiopulmonary support (PCPS) method for cardiopulmonary resuscitation, circulation support, respiratory support in emergency treatment. This percutaneous cardiopulmonary support method is a method of temporarily supporting and substituting for a cardiopulmonary function in extracorporeal circulation. In treatment accompanying extracorporeal circulation of artificial heart and lung, or the like, since blood is in an environment likely to be in contact with foreign bodies such as air, activated blood is likely to clot and form a thrombus. Therefore, a thrombus is inhibited from being formed by giving a dose of an anticoagulant such as heparin into blood during treatment. On the other hand, if an anticoagulant is overdosed, it may cause metrorrhagia, cerebral hemorrhage, and the like. Therefore, it is desirable that the degree of inhibition of blood clotting is inspected by performing a blood clotting inspection and the dosage of the anticoagulant is adjusted based on the result thereof. Examples of a method for a blood clotting inspection include a method of measuring an activated clotting time (ACT), in which an inspection result is obtained in a comparatively simple manner in a short time. According to a method of measuring an activated clotting time, an index of the readiness of blood to clotting can be obtained by measuring a clotting time of blood which is activated due to an added clotting accelerator. For example, PTL 1 discloses a method of measuring an activated clotting time, in which a clotting accelerator is added to blood disposed in a thin tube-shaped test tube, the blood is caused to flow in the test tube, and flow characteristics thereof are observed. Citation List Patent Literature PTL 1: United States Patent No. 5302348 In US patent number US8783121B2 a liquid collection system and a method therefor are disclosed. A blood collecting apparatus is disclosed that includes a cleaning solution piping. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured. In US patent application with publication number US2003/114785A1 a blood analyzing method and apparatus are disclosed. In Japanese patent application publication number JP 2001116666A an automatic sampling device for biological fluid is disclosed. In US patent application with publication number US 2007/212784A1 a high speed sample device is disclosed. Summary of Invention Technical Problem However, since an activated clotting time of blood changes from moment to moment, the activated clotting time needs to be repeatedly measured a plurality of times during treatment. If the activated clotting time is manually measured by a person, the processing time may be slow and deviations may occur during the interval between measurement times, so that it may not be possible to accurately and quickly recognize a change in the activated clotting times. In addition, after blood has clotted inside one particular test tube used for a particular measurement of the activated clotting time, the test tube needs to be replaced with another test tube for a next measurement. Therefore, each test tube can only be used to perform a single measurement in the prior art. In addition, blood inspections required for treatment are not limited to a clotting inspection. For example, it may be desirable to inspect for concentration of a component in blood, such as glucose. Similarly, in such a component inspection in blood as well, it is desirable for a chronological change to be measured and a dosage of a medicine such as insulin to be adjusted based on the result thereof. An object of the present invention is to provide a blood inspection system and control method, in which a condition of a patient can be chronologically measured by automatically repeating blood inspections a plurality of times at a desired interval and a desired timing and measuring a chronological change in a blood condition, so that a thrombus or the like is prevented from being formed, and a medicine is prevented from being overdosed. Solution to Problem The present invention is defined by the appended claims only, in particular by the scope of appended independent claim 1. Reference(s) to "embodiments" throughout the description which are not under the scope of the appended claims merely represent possible exemplary executions and are therefore not part of the present invention. In order to achieve the above object, there is provided a blood inspection system for inspecting blood. The blood inspection system includes a main flow path through which a fluid including blood circulates, a supply section which supplies a cleaning liquid to the