EP-3720563-B9 - ORAL CARE COMPOSITIONS

Inventors

• QUEIROZ, DANIEL
• TESTER, Chantel
• GIANO, MICHAEL C.
• CHEN, REBECCA
• GAMBOGI, ROBERT J.

Dates

Publication Date

20260506

Application Date

20181129

Claims (9)

1. A composition comprising an orally-acceptable carrier and an anionic copolymer derived from the polymerization of N-vinyl pyrrolidone (VP) with an anionic monomer compound containing phosphorus, wherein said anionic copolymer is described by Formula I below: wherein x, y, and z are integers and the ratio of "x" to "y+z" is from 1:99 to 99:1; R 1 is derived from methacryloxyethyl phosphate; and R 2 is a repeat unit selected from hydroxyethyl acrylate (HEA), 2-hydroxypropyl acrylate, 4-hydroxybutyl acrylate, 2-Hydroxyethyl methacrylate, Hydroxypolyethoxy allyl ether, 3-Phenoxy 2 hydroxy propyl methacrylate, glycerol monomethyacrylate and N-(2-Hydroxypropyl)methacrylamide; wherein the composition further comprises fluoride.
2. The composition of claim 1 wherein z is non-zero and R2 is derived from HEA.
3. The composition of claim 1 comprising from 0.01 to 2% of said anionic copolymer.
4. The composition of claim 1 wherein said composition is in a form selected form the group consisting of a mouthwash, mouth rinse, mouth spray, toothpaste, tooth gel, sub-gingival gel, mousse, foam, denture care product, dentifrice, lozenge, concentrate and chewable tablet.
5. The composition of claim 4 wherein said composition is a mouthwash comprising water, and at least one surfactant selected from the group consisting of anionic, cationic, non-ionic, zwitterionic surfactants and combinations of two or more thereof.
6. The composition of claim 5 further comprising at least one essential oil selected from the group consisting of menthol, thymol, eucalyptol, methyl salicylate, and combinations of two or more thereof.
7. The composition of claim 1 wherein said copolymer has a weight average molecular weight of from 10,000 to 1,000,000.
8. The composition of claim 7 wherein said copolymer has a weight average molecular weight of from 10,000 to 500,000.
9. The composition of any preceding claim for use in a method of inhibiting demineralization of a tooth by contacting a tooth surface with said composition.

Description

FIELD OF THE INVENTION The present invention relates to compositions comprising anionic PVP copolymers for use in oral care composition to prevent demineralization. The present invention relates to phosphorous-containing copolymers of vinyl pyrrolidone used to deliver demineralization prevention benefits. BACKGROUND OF THE INVENTION Caries is one of the most prevalent diseases affecting individuals globally. It is caused by the complex relationship between dental biofilms (plaque), the host and fermentation of dietary sugars to organic acids. Essentially, the acids produced effectively decrease the pH of the microenvironment below 5.5 resulting in enamel dissolution or demineralization. Rapid adjustment to near neutral pH occurs due to the high buffer capacity of saliva resulting in remineralization at the surface of enamel. An imbalance in de- and remineralization cycles, with more time spent in the demineralization, result in caries. Fluoride, renowned for prevention and repair of tooth decay, has been considered as a possible solution to regulated dental erosion. Recently, different types of micro-/nanoparticles (hydroxyapatite, bioglass, silica particles, etc.) have also been explored for their anti-erosion properties. Some divalent cations, such as calcium, zinc and stannous, have also been used to prevent demineralization. While fluoride has been widely used in consumer products, almost half of the population still suffers from caries. Micro-/nanoparticles show some efficacy in remineralization, but they are very challenging to formulate in mouth rinse and the efficacy highly depends on the retention time on enamel surface. For example, bioglass, such as that trademarked under the name NOVAMIN, (Novamin, etc.) can only be prepared in anhydrous formulations. Divalent cations also have limitations in either formulation or consumer experience, for example, zinc has a bitter after taste and stannous is known for causing teeth staining issue. Preventing the demineralization of teeth is rapidly gaining attention as a valid strategy to reduce occurrence and/or progression of dental decay. Hence, there is always a need to develop oral care compositions to prevent demineralization. WO2005027862A1 relates to oral care compositions comprising a polymer obtainable by copolymerising a mixture of comonomers, said mixture comprising: (a) a cationic monomer selected from (ar-vinylbenzyl) trimethylammonium chloride, (dimethylaminopropyl) methacrylamide, [2(methacryloyloxy)ethyl]trimethylammonium chloride, 2-aminoethylmethacrylate hydrochloride and mixtures thereof; and (b) at least one anionic or neutral monomer selected from styrene, mono-2-(methacryloyl)ethyl succinate, vinyl acetate, N,N-dimethylacrylamide, 2-ethylhexylacrylate, vinylphosphonic acid, acrylic acid, 2-acrylamido-2-methyl-1-propanesulfonic acid, N-[tris(hydroxymethyl)methyl] acrylamide, N-vinylpyrrolidone, butyl acrylate, 2-hydroxyethylacrylate, polyethyleneglycol methylethermethacrylate and mixtures thereof, said oral care composition in the form of any one of a toothpaste, gel, foam, chewing gum, deformable strip or mouthwash and which is suitable for use in the oral cavity. US2008305457A1 relates to a method of applying a dental agent to a dental surface, the method including: applying a retentive polymeric coating to a dental surface; and subsequently contacting the retentive polymeric coating with a loading composition that includes a dental agent, wherein the contacting occurs under conditions effective to incorporate the dental agent into the retentive polymeric coating for release over time, as well as polymers that include a hydrophobic segment, a hydrophilic segment, a quaternary amine segment, and an alkoxy silane crosslinkable segment; and polymers that include a hydrophobic segment, a hydrophilic segment, a silicon-containing macromer segment, and an alkoxy silane crosslinkable segment. WO2016173871A1 relates to the use of a composition which contains a peroxide compound and a specific, generically defined copolymer, for bleaching teeth. JP2992415B2 and JPH06157270A relate to a cosmetic for beautifying skin and hair wherein the cosmetic is obtained by blending a copolymer of 2-methacryloyloxyethylphosphorylcholine and a hydrophilic monomer (preferably having >=5,000 molecular weight) in an amount of preferably 0.001-10wt.% based on the total amount of the cosmetic with other ingredients and is capable of improving the skin and hair conditions such as skin roughening and insufficient gloss and enhancing the moisture retention without any unfavorable effects to touch. EP0897709A1 relates to a dental coating composition comprising a polymer which has in its molecule one or more phosphorus series acid residues selected from the group consisting of phosphoric acid, phosphonic acid and phosphinic acid and halides and salts thereof and has a weight-average molecular weight of 10,000 to 5,000,000, and water or a lower alcohol, wherein the composi