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EP-3826700-B1 - METHOD OF ADJUSTING MEDICATION DOSES

EP3826700B1EP 3826700 B1EP3826700 B1EP 3826700B1EP-3826700-B1

Inventors

  • MOLOY, Timothy

Dates

Publication Date
20260513
Application Date
20190723

Claims (13)

  1. A method of providing a medication dose adjustment using a computing device, the method comprising: receiving, by the computing device, an adjustment cycle time period; receiving, by the computing device, a threshold number of dose and fasting blood glucose measurement pairs, the threshold number of dose and fasting blood glucose measurement pairs being less than a total number of potential dose and fasting blood glucose measurement pairs possible in the adjustment time cycle period; receiving, by the computing device, a dose value and fasting blood glucose measurement value pair, the receiving comprising: receiving, by the computing device, a dose indicator comprising a medicament dose value and a medicament dose time; receiving, by the computing device, a fasting blood glucose measurement value comprising a fasting blood glucose level and a measurement time; determining, by the computing device, whether the dose time occurs within a first time range and the fasting blood glucose measurement occurs within a second time range, wherein the first time range is a usual dose time window comprising a range of times around a usual dose time, and the second time range is a measurement time window bounded at it earliest time by the dose time or the end of the usual dose time window and at its latest time by the end of a consecutive day and/or before a next medicament dose is received; and in response to a positive determination, associating, by the computing device, the dose indicator and the fasting blood glucose measurement to form the dose and fasting blood glucose measurement pair; determining, by the computing device, if a total number of dose and fasting blood glucose measurement pairs received within a current adjustment cycle time period meets the threshold number, the current adjustment cycle time period depending on the received adjustment cycle time period; in response to a positive determination that the threshold number is met, determining, by the computing device, if a dose adjustment is required based on the dose and fasting blood glucose measurement pairs received within an adjustment cycle time period; and outputting, by the computing device, the dose adjustment.
  2. The method of claim 1, wherein the current adjustment cycle time period comprises a period of time prior to receiving the dose and fasting blood glucose measurement pair equal to the adjustment cycle time period.
  3. The method of claim 1, wherein the current adjustment cycle time period comprises a period of time initiated by a predefined event.
  4. The method of claim 3, wherein the predefined event is an initial dose and fasting blood glucose measurement pair.
  5. The method of any of any of claims 3 or 4, wherein the method comprises: determining, by the computing device, if the threshold number of dose and fasting blood glucose measurement pair can be met within the current adjustment cycle time period; and in the event of a negative determination, initiating a new adjustment cycle time period.
  6. The method of any preceding claim, wherein receiving, by the computing device, an adjustment cycle time period and receiving, by the computing device, a threshold number of dose and fasting blood glucose measurement pairs comprises scanning, by a scanner of the computing device, a settings token.
  7. The method of any preceding claim, wherein the method further comprises: determining, by the computing device, if the received dose and fasting blood glucose measurement pair comprises a medicament dose quantity that is outside a safety threshold; and in response to a positive determination, providing, by the computing device, a corrective warning.
  8. The method of any of any preceding claim, wherein the method further comprises: determining, by the computing device, if the total number of dose and fasting blood glucose measurement pairs is less than a predefined fraction of the total number of potential fasting blood glucose measurements in the adjustment cycle time period; and in response to a positive determination, causing a warning to be issued.
  9. The method of claim 8, wherein the predefined fraction is up to one third of the total number of potential dose and fasting blood glucose measurement pairs.
  10. The method of any preceding claim, further comprising: determining, by the computing device, if a fasting blood glucose measurement is below a hypoglycaemic threshold; in response to a positive determination, determining, by the computing device, a dose adjustment based on the fasting blood glucose measurement; and outputting, by the computing device, the dose adjustment.
  11. The method of claim 10, further comprising: in response to a positive determination that the fasting blood glucose measurement is below a hypoglycaemic threshold, initiating, by the computing device, a new current adjustment cycle time period.
  12. Apparatus comprising: one or more processors; and a memory, the memory comprising instructions that, when executed by the one or more processors, causes the apparatus to perform the method of any preceding claim.
  13. A computer program comprising computer readable instructions that, when executed by computer apparatus, cause the computing apparatus to perform the method of any of claims 1-11.

Description

Field This specification relates to a method, apparatus and system for adjusting medicament doses. In particular, this specification relates to the automatic recommendation of medicament doses based on relaxed dosing regimen to a blood glucose measurement schedule. Background Blood glucose monitoring forms an important part of the management of diabetes in diabetic patients. Regular blood glucose monitoring allows a diabetic patient to more effectively plan their medication regimen, meals and activities. One type of blood glucose measurement is a fasting blood glucose (FBG) measurement. Blood glucose measurements are often paired with medicament doses, such as insulin doses, in order to monitor the effectiveness of the patient's medicament regimen. This allows for the patient's medicament regimen to be adjusted based in the measured effect of the medicament on the patient's blood glucose level. However, in some circumstances diabetic patients may not check their blood glucose measurements on a regular basis, for example due to a lack of medical supplies, or simply due to forgetfulness. This can affect the provision of any treatment recommendations based on their blood glucose measurements. US 2017/228518 A1 discloses a method of administering insulin that includes receiving scheduled blood glucose time intervals and obtaining blood glucose data of a patient that includes blood glucose measurements, blood glucose times, and insulin dosages previously administered by the patient. The method also includes applying a set of filters to identify which of the blood glucose measurements associated with at least one of the scheduled time intervals are usable and which of the blood glucose measurements associated with the at least one scheduled time interval are unusable. US 2012/232520 A1 discloses methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations. US 2016/117481 A1 discloses q method of administering insulin that includes receiving subcutaneous information for a patient at a computing device and executing a subcutaneous outpatient program for determining recommended insulin dosages. The subcutaneous outpatient program includes obtaining blood glucose data of the patient from a glucometer in communication with the computing device, aggregating blood glucose measurements to determine a representative aggregate blood glucose measurement associated with at least one scheduled blood glucose time interval, and determining a next recommended insulin dosage for the patient based on the representative aggregate blood glucose measurement and the subcutaneous information. Summary The invention is defined in the appended claims. According to a first aspect, this specification describes a method of providing a medication dose adjustment using a computing device, the method comprising: receiving, by the computing device, an adjustment cycle time period; receiving, by the computing device, a threshold number of dose and blood glucose measurement pairs, the threshold number of dose and blood glucose measurement pairs being less than a total number of potential dose and blood glucose measurement pairs possible in the adjustment time cycle period; receiving, by the computing device, a dose and blood glucose measurement pair; determining, by the computing device, if a total number of dose and blood glucose measurement pairs received within a current adjustment cycle time period meets the threshold number, the current adjustment cycle time period depending on the received adjustment cycle time period; in response to a positive determination that the threshold number is met, determining, by the computing device, if a dose adjustment is required based on the dose and blood glucose measurement pairs received within an adjustment cycle time period; and outputting, by the computing device, the dose adjustment. Receiving, by the computing device, the dose and blood glucose measurement pair comprises: receiving, by the computing device, a dose indicator comprising a medicament dose value and a medicament dose time; receiving, by the computing device, a blood glucose measurement comprising a blood glucose level and a measurement time; determining, by the computing device, if the medicament dose time and the measurement time satisfy one or more predefined criteria; and in response to a positive determination, associating, by the computing device, the dose indicator and the blood glucose measurement to form the dose and blood glucose measurement pair. Determining, by the computing device, if the medicament dose time and the measuremen