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EP-3834855-B1 - PRE-MIXED STRONTIUM SILICATE-BASED BIOLOGICAL HYDRAULIC CEMENTING PASTE COMPOSITION, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

EP3834855B1EP 3834855 B1EP3834855 B1EP 3834855B1EP-3834855-B1

Inventors

  • WU, Bingmin

Dates

Publication Date
20260513
Application Date
20190722

Claims (14)

  1. A pre-mixed strontium silicate-based cement paste composition, which is characterized in , the pre-mixed strontium silicate-based cement paste composition includes: component (a): at least one strontium silicate compound; component (b): at least one substantially anhydrous liquid carrier mixed with the at least one strontium silicate compound; wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid component (a) accounts for 60%-92% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition; wherein, the strontium silicate compound is selected from strontium silicate, tristrontium silicate, distrontium silicate, and mixtures thereof; wherein, the substantially anhydrous liquid carrier is selected from ethylene glycol, propylene glycol, polyethylene glycol, liquid glycerin, ethanol, a silicone oil, clove oil, an animal oil, a vegetable oil, an organic acid, and mixtures thereof.
  2. The pre-mixed strontium silicate-based cement paste composition according to claim 1, wherein, the strontium silicate-based cement paste composition further includes: component (c): at least one radiopaque material.
  3. The pre-mixed strontium silicate-based cement paste composition according to claim 2, wherein, the radiopaque material is selected from at least one of zirconium oxide, bismuth oxide and tantalum oxide.
  4. The pre-mixed strontium silicate-based cement paste composition according to claim 2, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid components (a) and (c) account for 60%-92% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  5. The pre-mixed strontium silicate-based cement paste composition according to claim 4, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid component (a) accounts for 20%-82% of the total mass of the cement paste composition, the solid component (c) accounts for 10%-40% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  6. The pre-mixed strontium silicate-based cement paste composition according to claim 1, wherein, the strontium silicate-based cement paste composition further includes: component (d): at least one calcium phosphate compound.
  7. The pre-mixed strontium silicate-based cement paste composition according to claim 6, wherein, the calcium phosphate compound is selected from at least one of tricalcium phosphate, tetracalcium phosphate, calcium dihydrogen phosphate and hydroxyapatite.
  8. The pre-mixed strontium silicate-based cement paste composition according to claim 6, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid components (a) and (d) account for 60%-92% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  9. The pre-mixed strontium silicate-based cement paste composition according to claim 8, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid component (a) accounts for 10%-42% of the total mass of the cement paste composition, the solid component (d) accounts for 10%-40% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  10. The pre-mixed strontium silicate-based cement paste composition according to claim 2, wherein, the strontium silicate-based cement paste composition further includes: component (d): at least one calcium phosphate compound.
  11. The pre-mixed strontium silicate-based cement paste composition according to claim 10, wherein, the calcium phosphate compound is selected from at least one of tricalcium phosphate, tetracalcium phosphate, calcium dihydrogen phosphate and hydroxyapatite.
  12. The pre-mixed strontium silicate-based cement paste composition according to claim 10, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid components (a), (c) and (d) account for 60%-92% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  13. The pre-mixed strontium silicate-based cement paste composition according to claim 12, wherein, in the pre-mixed strontium silicate-based cement paste composition, the solid component (a) accounts for 10%-42% of the total mass of the cement paste composition, the solid component (c) accounts for 10%-40% of the total mass of the cement paste composition, the solid component (d) accounts for 10%-40% of the total mass of the cement paste composition, and the liquid component (b) accounts for 8%-40% of the total mass of the cement paste composition.
  14. Use of the pre-mixed strontium silicate-based cement paste composition according to claim 1 in the preparation of a filling material for osteology or dentistry.

Description

Technical field The disclosure relates to a hydraulic cement paste for biomedical applications, and more specifically, to a pre-mixed strontium silicate-based cement paste composition with biological hydraulic properties for use in osteology, dentistry and orthopedics applications, and preparation method and use thereof. The disclosure belongs to the field of medical technology. Background It is well known that strontium silicate and calcium silicate can be hydrated when mixed with water, and solidify and harden by precipitating colloidal strontium silicate and calcium silicate hydrates (Sr-S-H, C-S-H), similar to ordinary Portland cement (OPC). These silicate-based bio-cement materials have good applications in the biomedical field, especially as dental filling materials in dental clinics, and have been widely used. An ideal dental filling material must have good biocompatibility, antibacterial properties and clinical operability. In addition, biological activity is considered as a basis for measuring the performance of materials bonding to tooth body. Therefore, bio-cement materials have also received more and more attention from dentists and researchers. At present, the most widely used calcium silicate-based material in dental filling materials is Mineral Trioxide Aggregate (MTA). Mahmoud Torabinejad first disclosed a method of repairing tooth cavities with MTA materials in 1998 (US Patent 5,769,638). The main components of the MTA material are tricalcium silicate and dicalcium silicate, which are similar to Portland cement and can be used in root canal filling materials, but the formulation is troublesome and also causes waste. The Chinese patent application (application number CN200880011743.1) entitled "Pre-mixed biological hydraulic cement paste composition and use thereof" discloses a pre-mixed cement paste that can be used for medical or dental applications. In this patent, tricalcium silicate, dicalcium silicate and an organic solvent are premixed. This is convenient for doctors to use, but the setting time is too long, which needs 72 hours to solidify in some cases. Too long setting time not only causes the patient to wait longer, but also makes the surgical procedure more complicated. The Chinese patent application (application number CN200910197934.8) entitled "Injectable efficient suspended stable calcium phosphate cement and preparation method and use thereof" discloses an injectable calcium phosphate cement material system. This patent improves the suspension stability of the calcium phosphate cement premix system by adding fumed silica and modified product thereof. The disadvantage is that the calcium phosphate cement has insufficient strength and is easily broken. Therefore, it is of great significance to further develop a pre-mixed biological hydraulic cement paste with short setting time, high biological activity, sufficient compressive strength and good clinical operability. Strontium is an indispensable microelement in the human body, and it is a normal part of human bones and teeth. The normal concentration of strontium in human bones is 360 ppm, and 99.0% of the strontium in vivo is present in bones and teeth. The main function of strontium on the human body is closely related to the formation of bones. Studies have shown that strontium can regulate the differentiation of MSCS (marrow mesenchymal stem cells) into osteoblasts and promote the synthesis and precipitation of bone matrix proteins. Therefore, strontium can promote osteoblast differentiation and osteogenesis. Strontium can also substitute a small amount of calcium in hydroxyapatite crystals in calcified tissue bones and teeth. The substitution with a small amount of strontium element can reduce lattice defects, make the arrangement of atoms closer, and produce a certain strengthening effect, thereby improving the bone strength of the teeth. While the strontium silicate hydrate (Sr-S-H) composite hydroxyapatite composition plays the role of filling and sealing, it has better biocompatibility, and functions to promote bone formation and improve bone strength, compared with calcium silicate hydrate (C-S-H),. CN105311680A discloses a liquid scaffold material for bone repair and its preparation method. The liquid scaffold material is prepared from the following raw materials: calcium sulfate, calcium polyphosphate, calcium tantalate, strontium silicate, modified graphene, polylactic acid hydroxy acetic acid copolymer, palmitoyl pentapeptide, wollastonite, polyglycerol lactate, cactus seed oil, silk fibroin, acetic acid, urea, distilled water and glycerin. The liquid scaffold material pursues degradation performance and does not involve curing time. CN105311680A discloses a preparation method of calcium phosphate bone cement that simultaneously releases zinc ions and silicate ions, which comprises the following steps: (1) mixing calcium phosphate bone cement powder, inorganic salt containing zinc ions, and inorganic salt contain