EP-3991738-B1 - CONSTITUENT FOR USE IN THE PREVENTION AND/OR TREATMENT OF A SKIN WOUND

Inventors

• ISHIHARA SHINSUKE
• IYI NOBUO
• SAKAUE SHIGEKI
• KAKINOHANA Manabu

Dates

Publication Date

20260506

Application Date

20200615

Claims (5)

1. A constituent for use in the prevention and/or treatment of a skin wound, wherein the constituent contains a sustained hydrogen sulfide releasing agent which is a layered double hydroxide having HS - and/or S k 2- between layers where k is a positive integer.
2. The constituent for use in the prevention and/or treatment of a skin wound according to claim 1, wherein the layered double hydroxide having HS - and/or S k 2- between layers is represented by the following general formula (1): Q x R(OH) 2(x+1) {(HS - , 0.5S k 2- ) y Z t } · nH 2 O (1) wherein Q is a divalent metal ion, R is a trivalent metal ion, Z is an anion other than HS - or S k 2- , x is a number that satisfies 1.8 ≦ x ≦ 4.2, y is a number that satisfies 0.01 ≦ y ≦ 2.0, t is a number that satisfies 0 ≦ t ≦ 1.0, and n is a number that changes or varies depending on an environmental humidity.
3. The constituent for use in the prevention and/or treatment of a skin wound according to claim 2, wherein in general formula (1) Q is at least one selected from the group consisting of Mg 2+ and Ca 2+ , and R is Al 3+ .
4. The constituent for use in the prevention and/or treatment of a skin wound according to any one of claims 1 to 3, wherein said skin wound is a skin ulcer.
5. The constituent for use in the prevention and/or treatment of a skin wound according to claim 4, wherein said skin ulcer is a bedsore.

Description

The present invention relates generally to a constituent for preventing and/or treating skin wounds. Any references in the description to methods of treatment refer to the compounds, pharmaceutical compositions and medicaments of the present invention for use in a method for treatment of the human (or animal) body by therapy. Background Art Being physical damage to surface tissues of the body, the wound is a general term for wounds with or without openings. In most cases, a slight wound heals over naturally without recourse to any particular treatment. A severe wound usually heals over by way of natural healing power, too, if it is properly treated by suturing, skin grafting, etc. There are, however, not a few cases where wound healing takes too long time with respect to intractable ulcers such as bedsores, venous stasis ulcers, arterial ulcers, diabetic ulcers and radiation ulcers. In some cases, it takes too long time for patients undergoing an operation to heal operative wound primarily because of a lowering of their natural healing power caused by their own diseases or medication. Of such intractable wounds, the bedsore observed in long bedridden patients is a necrotic skin ulcer caused by a long-standing application of certain or higher pressures to the skin. In recent years, accompanied by the progression of aging population, patients suffering from bedsores while spending a long time confined to bed have tended to increase in number. To deal with this situation, various proposals of therapeutic drugs or methods for treating wounds inclusive of bedsores. For instance, Patent Publication 1 discloses that sodium glutamate is orally administrated to patients in the form of an internal medicine, and Patent Publication 2 discloses that a wound treating agent containing glutamine, polydextrose, lactulose and bifidobacteria is orally administrated to patients. Referring to an external preparation and its administration method, Patent Publication 3 discloses that an external preparation containing either one of hydrophilic or white petrolatum and povidone iodine is coated on a wound surface. Also, Patent Publication 4 discloses that hydrogen-containing water is used as a liquid for external use in which a bedsore site is immersed, the hydrogen-containing water is added dropwise onto the bedsore site and a coating means soaked with the hydrogen-containing water is affixed to the bedsore site. Further, Patent Publication 5 discloses that cotton gauze soaked with fradiomycin sulfate and trafermin is packed in the back of an ulcer. Furthermore, Patent Publication 6 discloses that a "wound coating material" composed of a sponge layer containing crosslinked hyaluronic acid, silver sulfadiazine and crosslinked alginic acid and an unwoven fabric layer is applied to a wound surface. On the other hand, hydrogen sulfide (H2S)-containing spa has been used for folk remedies from old, because it has been known to be efficacious against skin diseases or circulatory diseases. However, hydrogen sulfide (H2S) is difficult to handle on a daily basis because of its toxicity. In recent years, this hydrogen sulfide has been reported to have bioactivities such as cell protective action, blood vessel relaxing action, antioxidant action, neurotransmission regulation action and apoptosis inhibition action under low concentration conditions. As such biological activities of hydrogen sulfide have been clearly understood, brisk trials of applying this to medical treatments are now under way. For instance, Patent Publication 7 discloses that viability of mice is improved when they are exposed to a H2S atmosphere at 80 ppm to place them in "stasis conditions" where their activity is recovered. Patent Publication 8 discloses a technical idea wherein a fluid having a therapeutic gas having vasodilatory action such as hydrogen sulfide is added or exposed to a biocompatible polymer matrix containing a polymer and closed cells and comprising a surface configured to come in direct contact with a wound site to store said therapeutic gas in said polymer matrix thereby delivering said therapeutic gas to said wound site. Patent Publication 9 discloses a hydrogen sulfide sustained release dressing comprising a hydrocolloid, a surfactant and sodium hydrosulfide. Prior Arts Patent Publications Patent Publication 1: JP(A) 2009-191015Patent Publication 2: JP(A) 2015-120646Patent Publication 3: JP(A) 2010-77143Patent Publication 4: JP(A) 2011-219411Patent Publication 5: JP(A) 2016-77514Patent Publication 6: JP(A) 2001-212170Patent Publication 7: Japanese Unexamined Patent Application Publication No. 2008-538569Patent Publication 8: Japanese Unexamined Patent Application Publication No. 2019-507622Patent Publication 9: CN 109 793 919 A Summary of the Invention Problems to be Solved by the Invention As described above, various methods have so far been reported to treat wounds inclusive of bedsores, and various medical treatment methods harnessing the bioact