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EP-4037633-B1 - MEDICAMENT FILLING SYSTEM

EP4037633B1EP 4037633 B1EP4037633 B1EP 4037633B1EP-4037633-B1

Inventors

  • GYORY, J. RICHARD
  • NEWBY, MARK
  • WILKINSON, BRADLEY
  • PETERSON, BART
  • PIZZOCHERO, ALESSANDRO
  • GRIGORYANTS, SERGEY
  • YU, Bo Yang
  • DANI, Heena

Dates

Publication Date
20260513
Application Date
20200925

Claims (8)

  1. A medicament filling system (30) that provides medicament to a delivery device (20), the medicament filling system comprising: a main housing (40) having: an air pump (42); a vial adapter (44) that is configured to engage a vial (10) containing medicament, the vial adapter being in communication with the air pump; a barrel (46) being in selective communication with the vial adapter and the delivery device; and a valve (60) that locks and unlocks movement of a plunger (72) in the barrel, characterized in that the valve includes a button connected to a stopping element that engages and disengages the plunger in the barrel; wherein when the button is depressed, the plunger in the barrel is disengaged from the stopping element, wherein the valve further includes: an arm including the stopping element (66) on a distal end of the arm; and a pivot shaft; wherein the arm rotates with respect to the pivot shaft to engage and disengage the stopping element to the plunger in the barrel.
  2. The medicament filling system of claim 1, wherein: the valve (60) is unlocked for the barrel to remove air from the delivery device; the valve is locked to prevent the barrel from receiving the medicament from the vial adapter beyond a preset dose; the valve is unlocked to deliver the medicament from the barrel to the delivery device; and the valve is locked after the medicament delivery to prevent backflow from the delivery device into the barrel.
  3. The medicament filling system of claim 1, wherein: the plunger (72) of the barrel (70) vents air from the barrel; the plunger includes a dial dose (74) at a proximal end of the plunger and corresponding dial dose stop (76) positions to indicate dosage; and the barrel includes a viewing window (48) to indicate an amount of the medicament disposed in the barrel.
  4. A method of using a medicament filling system (30) in accordance with any of claims 1-3 to fill medicament into a delivery device (20), the method comprising: attaching the medicament filling system to the delivery device; establishing fluid communication between the delivery device and the medicament filling system; connecting a vial (10) to the medicament filling system to establish fluid communication; setting a dose on a plunger (72) of a barrel (70) in the medicament filling system; releasing the barrel via a valve to allow for operation of the plunger; pulling the plunger to remove air from the delivery device; locking the plunger via the valve to prevent movement of the plunger and the barrel; transferring the medicament from the vial to the barrel; depressing the valve to release the plunger for operation; and filling the delivery device with medicament.
  5. The method of claim 4, comprising rotating the plunger of the barrel to set the dosage.
  6. The method of claim 4, comprising piercing a septum in the delivery device to establish fluid communication to the medicament filling system.
  7. The method of claim 4, comprising pumping air into the vial to transfer the medicament from the vial to the barrel.
  8. The method of claim 4, comprising venting excess air from the plunger of the barrel.

Description

FIELD OF THE INVENTION Various exemplary embodiments of the invention relate to filling a delivery device with medicament via a medicament filling system such as a syringe assembly. BACKGROUND OF THE INVENTION Systems such as delivery devices and syringe assemblies are typically used to inject medication, such as insulin, into a patient. However, inefficiencies and inconveniences can arise. These challenges include minimizing air entering into the delivery device, preventing medicament backflow from exiting the delivery device during and after the filling step, and improving safety, handling and stability. US Patent No. US2016/144105A1 discloses a drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring a drug are disclosed. The system may include a transfer apparatus and an injection device. The transfer apparatus may have receiving stations for a drug source, such as a vial or vial holder, and for an injection device, and fluid flow pathways for transferring drugs from the source into the injection device. The injection device may include an expandable elastic bladder and an injection cannula that is movable between a plurality of positions. Patent No. US2015/053305A1 discloses a syringe fill system, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for "push-pull", "pull-push", "push-push", and "pull-pull" modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system. SUMMARY OF THE INVENTION It is an aspect of the present invention to provide a medicament filling system and a method of using a medicament filling system in accordance with the independent claims. Preferred aspects are further defined by the dependent claims. Additional and/or other aspects and advantages of the present invention will be set forth in the description that follows, or will be apparent from the description, or may be learned by practice of the invention. BRIEF DESCRIPTION OF THE DRAWINGS The above aspects and features of the present invention will be more apparent from the description for the exemplary embodiments of the present invention taken with reference to the accompanying drawings, in which: Figure 1 is a first exemplary embodiment of a schematic of a medicament filling system;Figure 2 is a perspective view of the medicament filling system of Figure 1;Figure 3 is a transparent perspective view of the medicament filling system of Figure 2;Figure 4 is a cross-sectional view of the medicament filling system along line A-A of Figure 2 shown when removing air from a delivery device;Figure 5 is a cross-sectional view of the medicament filling system along line A-A of Figure 2 shown when delivering medicament to the delivery system;Figure 6 is a second exemplary embodiment of a schematic of a medicament filling system;Figure 7 is an exploded view of the medicament filling system of Figure 6;Figure 8 is an exploded view of a syringe assembly used with the medicament filling system of Figure 7;Figure 9 is a perspective view of a plunger lock assembly used with the syringe assembly of Figure 8;Figure 10 is a cross-sectional view of the plunger lock assembly along line B-B of Figure 9;Figure 11 is a perspective view of a third exemplary embodiment of a syringe assembly attached to a vial via an adapter;Figure 12 illustrates a first embodiment of an adapter used in the syringe assembly of Figure 11;Figure 13 illustrates a second embodiment of an adapter used in the syringe assembly of Figure 11;Figure 14 illustrates a third embodiment of an adapter used in the syringe assembly of Figure 11;Figure 15 illustrates the adapter used in the syringe assembly of Figure 11 when disengaged from the vial;Figure 16 is a side perspective view of a fourth exemplary embodiment of a syringe assembly having an integrated adapter attached to a vial;Figure 17 is a top perspective view of the syringe assembly of Figure 16;Figure 18 is a bottom perspective view of the syringe assembly of Figure 16 mounted to a delivery device;Figure 19 is a perspective view of a fifth exemplary embodiment of a syringe assembly without an adapter;Figure 20 is a perspective view of the syringe assembly of Figure 19 engaged to a vial to fill with medicament;Figure 21 is a perspective view of the syringe assembly of Figure 19 engaged to a delivery device to transfer medicament;Figure 22 is an exploded view of a sixth exemplary embodiment of a needleless syringe assembly with an adapter having a needle and a vial;F