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EP-4262935-B1 - MEDICAMENT DELIVERY MEMBER HOUSING ASSEMBLY

EP4262935B1EP 4262935 B1EP4262935 B1EP 4262935B1EP-4262935-B1

Inventors

  • YIN, MING-TING

Dates

Publication Date
20260506
Application Date
20211203

Claims (15)

  1. A medicament delivery member housing assembly (10) extending along an axis (12) in a longitudinal direction (13) from a proximal end (14) to a distal end (16), wherein the proximal end of the medicament delivery member housing assembly is the end of the medicament delivery member housing assembly closest to the site of delivery of a medicament during use, the medicament delivery member housing assembly (10) comprising: a housing (20) comprising a body (22) and a flexible arm (24), the flexible arm (24) extending in the longitudinal direction (13) from a proximal end moveable relative to the body (22) to a distal end attached to the body (22), wherein the flexible arm (24) comprises a first surface (26) facing towards the proximal end of the medicament delivery member housing assembly (10) and a second surface (28) facing in a radial direction (18) relative to the axis (12); a medicament delivery member (30); a proximal shield (40) extending around a first end of the medicament delivery member (30), the proximal shield (40) comprising a surface (42) facing towards the distal end of the medicament delivery member housing assembly (10) to interact with the first surface (26) of the housing (20) during use; and a distal shield (60) extending around a distal end of the medicament delivery member (30), the distal shield (60) being slidable in the longitudinal direction (13) relative to the proximal shield (40), the distal shield (60) comprising a surface (62) facing in the radial direction (18) to interact with the second surface (28) of the housing (20) during use; wherein the surface (62) facing in the radial direction is configured to interact with the second surface (28) of the housing (20) during use so as to move the first surface (26) out of alignment with the surface (42) facing towards the distal end of the medicament delivery member housing assembly (10).
  2. The medicament delivery member housing assembly of claim 1, wherein the medicament delivery member is a needle attached to the housing.
  3. The medicament delivery member housing assembly of claim 1 or 2, wherein the medicament delivery member housing assembly is configured to move from an initial extended position in which the medicament delivery member is fully enclosed by the medicament delivery member housing assembly to a final compressed position where the medicament delivery member extends out of the proximal end of the proximal shield and where the medicament delivery member extends out of the distal end of the distal shield.
  4. The medicament delivery member housing assembly of any one of claims 1 to 3, wherein the medicament delivery member housing assembly is configured to move from the initial extended position to an intermediate partially-extended position and then to a final compressed position, wherein in the initial extended position, the first surface of the flexible arm and the surface of the proximal shield are aligned in the longitudinal direction, wherein in the intermediate partially-extended position, the first surface of the flexible arm and the surface of the proximal shield are offset from one another in the longitudinal direction and adjacent to one another in the radial direction, and the second surface of the flexible arm is adjacent to the surface of the distal shield, wherein in the final compressed position, the surface of the proximal shield is further from the proximal end of the proximal shield than the first surface of the flexible arm is from the proximal end of the proximal shield.
  5. The medicament delivery member housing assembly of any of claims 1 to 4, wherein the second surface of the flexible arm faces away from the axis in the radial direction and the surface of the distal shield faces towards the axis in the radial direction.
  6. The medicament delivery member housing assembly of any previous claim, wherein the proximal end of the proximal shield comprises a septum which the medicament delivery member can penetrate, and wherein the distal end of the distal shield comprises a septum which the medicament delivery member can penetrate.
  7. The medicament delivery member housing assembly of any previous claim, wherein the first surface of the flexible arm and the surface of the proximal shield are spaced apart in the longitudinal direction.
  8. The medicament delivery member housing assembly of any previous claim, comprising a seal arranged between the proximal shield and the distal shield.
  9. The medicament delivery member housing assembly of claim 8, wherein the seal is attached to only one of the proximal shield and the distal shield.
  10. The medicament delivery member housing assembly of claim 9, wherein the one of the proximal shield and the distal shield that the seal is not attached to comprises a recess, and the seal extends into the recess.
  11. The medicament delivery member housing assembly of claim 9, wherein the one of the proximal shield and the distal shield that the seal is not attached to comprises a protrusion extending in the radial direction, and the seal abuts the protrusion.
  12. The medicament delivery member housing assembly of any previous claim, wherein the housing is attached to the distal shield by a snap fit and/or the distal shield is attached to the proximal shield by a snap fit.
  13. The medicament delivery member housing assembly of any previous claim, wherein the distal shield has a greater radius measured perpendicular to the axis than the proximal shield.
  14. A cassette comprising a medicament delivery member housing assembly as described in any previous claim.
  15. An autoinjector comprising a medicament delivery member housing assembly as claimed in any of claims 1 to 13 or comprising a cassette as claimed in claim 14.

Description

TECHNICAL FIELD The invention concerns medicament delivery member housing assemblies, and particularly medicament delivery member housing assemblies with shields protecting the medicament delivery member. BACKGROUND In cartridge-based medicament delivery devices such as autoinjectors, it is important that the medicament delivery member (e.g. a needle) is kept safe before use, both to avoid needle stick injuries and also to maintain sterility. In addition, cartridge-based medicament delivery devices are typically provided with the medicament delivery member separated from the medicament container, which means that the user typically has to somehow attach the medicament delivery member to the medicament container before carrying out an injection. Some examples can be found in US2011/125100 and US2015/273161. This adds extra steps and therefore extra complexity to device usage, which is undesirable in terms of ease of use. Considering this, the applicant has appreciated that improvements can be made in comparison to existing designs. SUMMARY The invention is defined by the appended claims, to which reference should now be made. In the present disclosure, when the term "distal direction" is used, this refers to the direction pointing away from the dose delivery site during use of the medicament delivery device. When the term "distal part/end" is used, this refers to the part/end of the delivery device, or the parts/ends of the members thereof, which under use of the medicament delivery device is/are located furthest away from the dose delivery site. Correspondingly, when the term "proximal direction" is used, this refers to the direction pointing towards the dose delivery site during use of the medicament delivery device. When the term "proximal part/end" is used, this refers to the part/end of the delivery device, or the parts/ends of the members thereof, which under use of the medicament delivery device is/are located closest to the dose delivery site. Further, the terms "longitudinal", "longitudinally", "axially" and "axial" refer to a direction extending from the proximal end to the distal end and along the device or components thereof, typically in the direction of the longest extension of the device and/or component. Similarly, the terms "transverse", "transversal" and "transversally" refer to a direction generally perpendicular to the longitudinal direction. An aspect of the invention concerns a medicament delivery member housing assembly extending along an axis in a longitudinal direction from a proximal end to a distal end, the medicament delivery member housing assembly comprising: a housing comprising a body and a flexible arm, the flexible arm extending in the longitudinal direction from a proximal end moveable relative to the body to a distal end attached to the body, wherein the flexible arm comprises a first surface facing towards the proximal end of the medicament delivery member housing assembly and a second surface facing in a radial direction relative to the axis; a medicament delivery member; a proximal shield extending around a first end of the medicament delivery member, the proximal shield comprising a surface facing towards the distal end of the medicament delivery member housing assembly to interact with the first surface of the housing during use; and a distal shield extending around a distal end of the medicament delivery member, the distal shield being slidable in the longitudinal direction relative to the proximal shield, the distal shield comprising a surface facing in the radial direction to interact with the second surface of the housing during use. This design can provide a built-in needle-housing assembly for cartridge-based autoinjectors. This design can first connect the distal end of the needle to a cartridge and penetrate the proximal end of the proximal shield and subsequently an injection site with a simple linear compressive motion. As such, it can be implemented into a device activation mechanism (e.g. a needle cover compression), and can thereby avoid the need for any additional user preparation steps. Preferably, the medicament delivery member housing assembly comprises a needle attached to the housing. Preferably, the proximal end of the medicament delivery member housing assembly is the end of the medicament delivery member housing assembly closest to the site of delivery of a medicament during use. With the housing assembly this way around, a medicament container can be penetrated before a medicament delivery member extends out of the proximal end of the housing assembly. Preferably, the medicament delivery member housing assembly is configured to move from an initial extended position in which the needle is fully enclosed by the medicament delivery member housing assembly to a final compressed position where the needle extends out of the proximal end of the proximal shield and where the needle extends out of the distal end of the distal shield. Preferably, the med