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EP-4279921-B1 - IMMUNE REACTION ANALYSIS DEVICE EQUIPPED WITH INCUBATION CHAMBER

EP4279921B1EP 4279921 B1EP4279921 B1EP 4279921B1EP-4279921-B1

Inventors

  • AN, Jae Un
  • PARK, DONG KI
  • IM, UK BIN
  • IM, Youn Tae
  • CHA, MIN SEOK
  • LEE, KANG HYUK
  • PARK, JAE HO
  • SHIN, JEONG AE

Dates

Publication Date
20260506
Application Date
20211203

Claims (13)

  1. An immune reaction analysis device (100) comprising: an incubation chamber (104) which has a plurality of slits (706) for accommodating cartridges (101), and in which an incubation for an immunodiagnostic reaction is performed; a cartridge input driving unit (102) for inputting the cartridge into the slit of the incubation chamber; a determination unit (110) for determining the result of the reaction in the cartridge; a cartridge withdrawal driving unit (106) for withdrawing the cartridge accommodated in the slit of the incubation chamber; a cartridge transfer driving unit (108) for transferring the withdrawn cartridge to the determination unit; and a control unit (114) for controlling the cartridge input driving unit, the cartridge withdrawal driving unit, and the cartridge transfer driving unit, wherein the incubation chamber includes a shelf (802) formed with a plurality of the slits arranged in a vertical direction, that is perpendicular to the driving direction of the cartridge input driving unit (102); and a shelf elevation unit (804) for driving the shelf in a vertical direction.
  2. The immune reaction analysis device of claim 1, further comprising: a cartridge discharge driving unit (112) for discharging a corresponding cartridge (101) to the outside after determination of an immune reaction result inside the cartridge located in the determination unit is completely determined.
  3. The immune reaction analysis device of claim 1, wherein the incubation chamber further includes a Peltier element (1002, 1004) attached to the shelf.
  4. The immune reaction analysis device of claim 3, wherein the incubation chamber further includes a temperature sensor (902, 904) attached to the shelf; wherein the control unit controls the Peltier element according to the measured value of the temperature sensor.
  5. The immune reaction analysis device of claim 1, wherein the incubation chamber further includes a chamber case (701) for accommodating the shelf and the shelf elevation unit.
  6. The immune reaction analysis device of claim 5, wherein on the front surface of the chamber case, a chamber inlet (602) for inputting a cartridge is formed at a first height and a chamber through-hole (612) is formed at a second height.
  7. The immune reaction analysis device of claim 6, wherein the cartridge input driving unit includes an injector (610) for inputting a cartridge into a slit positioned at the first height of the incubation chamber through the chamber inlet.
  8. The immune reaction analysis device of claim 6, wherein a chamber outlet (710) is formed at the second height on the rear surface of the chamber case.
  9. The immune reaction analysis device of claim 1, wherein the incubation chamber further includes: a cartridge sensor (1102) installed at an inlet of the slit; and a cartridge sensor (1104) installed at an outlet of the slit.
  10. The immune reaction analysis device of claim 8, wherein the control unit drives the shelf elevation unit to position the slit from the first height to the second height after a preset incubation time elapses.
  11. The immune reaction analysis device of claim 1, further comprising: a camera module (402) for photographing a housing of the cartridge which is input into a slit of the incubation chamber by means of the cartridge input driving unit; and a user interface (15) for displaying a specific location of the cartridge housing photographed by the camera module.
  12. The immune reaction analysis device of claim 1, further comprising: a barcode recognition module (512, 604) for recognizing a barcode printed on the housing of the cartridge which is input into the slit of the incubation chamber by means of the cartridge input driving unit.
  13. The immune reaction analysis device of claim 2, wherein the cartridge discharge driving unit includes a sensor (1702) for detecting whether or not the cartridge is discharged.

Description

TECHNICAL FIELD The present invention relates to an immune reaction analysis device, and more particularly to an immune reaction analysis device equipped with an incubation chamber. BACKGROUND ART With the development of technology in various related fields such as medicine and biotechnology, the tests for detecting various molecular indicators such as blood cells, genes, proteins, antigens, and pathogens in predetermined biological samples such as urine and blood have been widely performed. The inspection process is generally performed by taking a sample, reacting the collected sample with a predetermined reagent suitable for a desired indicator, and then analyzing and observing changes that occur.in this way, it is possible to perform qualitative and/or quantitative analysis on various molecular indicators included in the sample, and based on this, information on diagnosis, progression, prognosis, etc. of the disease can be obtained. The immune reaction based on specific binding between antigens/antibodies is widely used for such testing. Immune reaction technologies include a chromogenic method, a chemiluminescent method, a method using fluorescence, and the like, depending on the type of substrate used for the detection of an analyte. The immune reaction requires incubation for the reaction of reagents and samples. When using an analysis device without an incubation chamber, the user must perform incubation in a separate device. In this case, if a large number of tests are performed, it is so hard to control the incubation time for individual cartridges, that it is difficult to make an accurate diagnosis. In addition, since the user has to carry the incubated cartridge to the reading device, the user's workload increases. WO 2020/124255 A1 is directed to a flow assay analyzer. DETAILD DESCRIPTION OF THE INVENTION TECHNICAL PROBLEM Accordingly, an objective of the present invention is to provide an immune reaction analysis device with excellent usability. In addition, another objective of the present invention is to provide an immune reaction analysis device that performs a large number of incubations more accurately. In addition, another objective of the present invention is to provide an immune reaction analysis device with improved cartridge throughput per unit time. TECHNICAL SOLUTION The present invention for achieving the above-mentioned objectives provides an immune reaction analysis device according to claim 1 comprising: an incubation chamber which has a plurality of slits for accommodating cartridges, and in which an incubation for an immunodiagnostic reaction is performed; a cartridge input driving unit for inputting the cartridge into the slit of the incubation chamber; a determination unit for determining the result of the reaction in the cartridge; a cartridge withdrawal driving unit for withdrawing the cartridge accommodated in the slit of the incubation chamber; a cartridge transfer driving unit for transferring the withdrawn cartridge to the determination unit; and a control unit for controlling the cartridge input driving unit, the cartridge withdrawal driving unit, and the cartridge transfer driving unit. Preferably, the immune reaction analysis device further comprises a cartridge discharge driving unit for discharging a corresponding cartridge to the outside after an immune reaction result in the cartridge located in the determination unit is completely determined. The cartridge discharge driving unit includes a sensor for detecting whether or not the cartridge is discharged. Preferably, a plurality of slots are disposed in the incubation chamber in a direction perpendicular to the driving direction of the cartridge input driving unit. The incubation chamber includes: a shelf having a plurality of the slits formed thereon; and a shelf elevation unit for driving the shelf in a vertical direction. The incubation chamber further includes a Peltier element attached to the shelf. The incubation chamber further includes a temperature sensor attached to the shelf. The control unit controls the Peltier element according to the measured value of the temperature sensor. Preferably, the incubation chamber further includes a chamber case for accommodating the shelf and the shelf elevation unit. On the front surface of the chamber case, a chamber inlet for inputting a cartridge is formed at a first height and a chamber through-hole is formed at a second height. The cartridge input driving unit includes an injector for inputting a cartridge into a slit positioned at the first height of the incubation chamber through the chamber inlet. A chamber outlet is formed at the second height on the rear surface of the chamber case. The cartridge transfer driving unit includes an ejector for transferring the cartridge accommodated in the slit located at the second height of the incubation chamber to the determination unit through the chamber outlet. The control unit drives the shelf elevation unit to positio