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EP-4308248-B1 - COSMETIC SKIN CARE COMPOSITION

EP4308248B1EP 4308248 B1EP4308248 B1EP 4308248B1EP-4308248-B1

Inventors

  • AU, VAN
  • DAVIS, Andrew, John
  • GUELAKIS, Marian, Pereira
  • HARICHIAN, BIJAN
  • LATHROP, WILLIAM, F.
  • LEE, JIANMING
  • LU, Nandou
  • ROSA, JOSE, GUILLERMO

Dates

Publication Date
20260506
Application Date
20220310

Claims (8)

  1. A topical composition comprising: (a) a cosmetic skin benefit agent selected from 1-oleoyl-rac-glycerol, (2S)-1-oleoylglycerol, oleoyl-rac-glycerol (ORG), (2R)-1-oleoylglycerol, 2-oleoylglycerol, and/or mixtures thereof; (b) a retinoid, wherein the retinoid is retinyl propionate; and (c) a dermatologically acceptable vehicle.
  2. A topical composition according to claim 1, wherein the cosmetic skin benefit agent is 1-oleoyl-rac-glycerol.
  3. A topical composition according to any of the preceding claims, wherein the cosmetic skin benefit agent is 2-oleoylglycerol.
  4. A topical composition according to any of the preceding claims, wherein the composition further comprising cyclic phosphatidic acid (cLPA).
  5. A cosmetic method of providing at least one cosmetic skin care benefit selected from: treating/preventing wrinkling, sagging, dry, aged and/or photodamaged skin; boosting/maintaining collagen levels in skin, boosting/maintaining decorin levels in skin, enhancing tissue repair; improving skin texture, smoothness and/or firmness; promoting skin barrier recovery; the method comprising applying to the skin a topical composition as claimed in any preceding claim.
  6. Use of a topical composition as claimed in any of claims 1 to 4 for providing at least one cosmetic skin care benefit selected from treating/preventing wrinkling, sagging, aged, dry, and/or photodamaged skin, boosting/maintaining collagen levels in skin, boosting/maintaining YAP levels in skin cell nucleus, enhancing tissue repair; improving skin texture, smoothness and/or firmness and/or promoting skin barrier recovery.
  7. Use of oleoyl-rac-glycerol in combination with retinyl propionate as an activator of YAP activated receptors in a topical composition for providing at least one cosmetic skin care benefit selected from treating/preventing wrinkling, sagging, aged and/or photodamaged skin; boosting/maintaining collagen deposition in skin, boosting/maintaining decorin production in skin, enhancing tissue repair; improving skin texture, and smoothness and/or firmness and promoting skin barrier recovery.
  8. A topical composition according to any of claims 1 to 4, wherein the cosmetic skin benefit agent is ORG or an oil with ORG.

Description

FIELD OF THE INVENTION This disclosure relates to topical cosmetic compositions for application on human skin, as well as to their use in improving the condition and appearance of skin. BACKGROUND OF THE INVENTION Skin is subject to deterioration through dermatological disorders, environmental abuse (wind, air conditioning, central heating, pollution) or through the normal ageing process (chronoageing) which may be accelerated by exposure of skin to sun (photoageing). The demand for cosmetically improving the appearance and condition of human skin is universal and timeless. In particular, the enormous demand is for reversing, reducing or preventing the visible signs of wrinkled, aged and/or photodamaged skin. Consumers everywhere are continually seeking "anti-ageing" cosmetic products that reverse, treat or delay the visible signs of chronoaging and photoaging skin such as wrinkles, lines, sagging, hyperpigmentation and age spots. Collagen, the predominant matrix skin protein is known to impart tensile strength to skin. Levels of collagen in skin are significantly reduced with aged and/or photodamaged skin, i.e., collagen fibrils break down and do not receive mechano-transduction signals (see definition below). Many studies have shown that the levels of collagen type I in skin is decreased with age and/or with increased photodamage (for example Lavker, R.J. Inv. Derm., (1979, 73,79-66; and Griffiths et al. N. Eng. J. Med.(1993) 329, 530-535). The reduction of the levels of collagen in skin is associated with a decrease in the tensile strength of the skin, i.e., structural damage in aged skin, causing and appearing as wrinkles and laxity. Conversely, strengthening of the dermal matrix by boosting the level of collagen in skin provides anti-ageing/dermal repair benefits. The extracelluar matrix (ECM) once thought to function only as scaffold to structurally support cells, regulates many aspects of cell behavior, including morphology, proliferation, differentiation, and survival. Through the process of mechano-transduction, cells can convert mechanical stimuli into biochemical or transcriptional changes [Chiquet, M., et al., From mechanotransduction to extracellular matrix gene expression in fibroblasts. Biochim Biophys Acta, 2009. 1793(5): p. 911-20. Daley, W.P., S.B. Peters, and M. Larsen, Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci, 2008. 121(Pt 3): p. 255-64.] This signal transduction involves proteins of the ECM, the cytoplasmic membrane, the cytoskeleton and the nuclear membrane, eventually affecting the nuclear chromatin at a genetic and epigenetic level. Mechano-transduction signaling is a key driver of cell behavior. The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cellular phenotype. The recent identification of YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif), both transcriptional effectors of the Hippo pathway, as mechano-sensors and mechano-transducers, has begun to shed some light on the mechanism for cells sensing and transducing mechanical cues to regulate gene expression. SeeMohri, Z., A. Del Rio Hernandez, and R. Krams, The emerging role of YAP/TAZ in mechanotransduction. J Thorac Dis, 2017. 9(5): p. E507-E509. Dupont, S., Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction. Exp Cell Res, 2016. 343(1): p. 42-53. Halder, G., S. Dupont, and S. Piccolo, Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol, 2012. 13(9): p. 591-600. Zhang, H., H.A. Pasolli, and E. Fuchs, Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A, 2011. 108(6): p. 2270-5. Dupont, S., et al., Role of YAPlTAZ in mechanotransduction. Nature, 2011. 474(7350): p. 179-83. YAP and TAZ have been shown to function as key mechano-sensors and mechano-transducers, translating a broad range of mechanical cues from sheer stress and cell shape to ECM rigidity into cell-specific transcriptional programs. Proper dermal ECM mechanical properties sustain youthful fibroblast behavior. In young skin, fibroblast in the dermis are well spread, engaging via integrins, with the abundant and organized bundles of collagen fibrils. With (photo)ageing, collagen fibrils become fragmented and disorganized. Fibroblasts lose collagen (and other ECM) adhesion sites, resulting in a collapsed morphology, decreased TGFb signaling and production of collagen, and increased production of matrix-degrading enzymes. In this aged microenvironment, there is compromised force homeostasis between the cells and the fibrils of ECM, resulting in deficient mechano-transduction signaling [Fisher, G.J., et al., Reduction of fibroblast size/mechanical force down-regulates TGF-beta type II receptor: implications for human skin aging. Aging Cell, 2016. 15(1): p. 67-76. Qin, Z.