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EP-4413924-B1 - BRAIN NAVIGATION LEAD

EP4413924B1EP 4413924 B1EP4413924 B1EP 4413924B1EP-4413924-B1

Inventors

  • NAOR, OMER
  • BALAN, ADI
  • BERGMAN, HAGAI
  • YOUNIS, IMAD
  • GARGIR, Oren A.
  • ISRAEL, ZVI
  • ELFAR, Jubran

Dates

Publication Date
20260513
Application Date
20170314

Claims (15)

  1. A system configured for inferring at least one trajectory inside a brain tissue, the system comprising circuitry configured to perform: recording a plurality of signals from said brain tissue by electrodes positioned at different spatial locations inside the brain and along the insertion trajectory of a lead; analyzing said signals by functionally mapping brain tissue surrounding said insertion trajectory; inferring at least one additional trajectory or part of an additional trajectory at a distance from said insertion trajectory based on said functionally mapping; characterized in that said inferring is done automatically by means of an algorithm in said circuitry; and said at least one additional trajectory or part of an additional trajectory are spatially differentiated from said insertion trajectory.
  2. The system according to claim 1, further comprising updating an insertion step size of said lead based on said functionally mapping of said brain tissue following said analyzing.
  3. The system according to claim 1 or claim 2, wherein said recording comprising recording directional signals from sources located inside the brain in a distance of at least 0.2 mm from a measuring electrode on said lead.
  4. The system according to any one of claims 1-3, wherein said analyzing comprising separately analyzing each of said plurality of signals, and wherein said inferring comprising inferring a plurality of trajectories in a distance of at least 0.5 mm from said lead.
  5. The system according to anyone of claims 1-4, wherein said analyzing comprising analyzing said plurality of signals in a multi-channel model by a multi-channel algorithm, and wherein inferring comprising inferring a single trajectory based on the results of said multi-channel algorithm.
  6. The system according to any one of claims 1-5, further comprising a brain navigation device, comprising: a. a lead having an elongated lead body; b. at least one macro-electrode contact positioned on an outer surface on said lead; wherein said at least one macro-electrode contact is located at the distal part of said lead; c. at least one microelectrode contact positioned along said lead body distally to said at least one macro-electrode contact; and wherein said at least one macro-electrode contact and said at least one microelectrode contact are configured to be used during navigation of said lead.
  7. The system according to claim 6, wherein said at least one macro-electrode contact and said at least one microelectrode contact are configured to be used simultaneously.
  8. The system according to claim 6 or claim 7, wherein one or both of said at least one macro-electrode contact and said at least one microelectrode contact are configured to apply an electric field.
  9. The system according to any one of claims 6-8, wherein said at least one micro-electrode contact is located at a distal tip of said lead.
  10. The system according to any one of claims 6-9, wherein said at least one macro-electrode contact comprises at least one ring electrode contact and/or at least one segmented electrode contact.
  11. The system according to any one of claims 6-10, wherein said at least one microelectrode contact is configured to sense electrical activity of brain tissue.
  12. The system according to any one of claim 6-11, wherein said at least one microelectrode contact and said at least one macro-electrode contact are distributed along several angular positions on the lead circumference.
  13. The system according to any one of claims 6-12, further comprising at least one additional microelectrode contact on said lead.
  14. The system according to any one of claims 6-13, wherein said lead comprises at least two or more microelectrode contacts, and wherein said two or more microelectrode contacts are distributed along a circumference of said lead.
  15. The system according to any one of claims 6-14, wherein at least one microelectrode contact of said two or more microelectrode contacts is positioned at a distal tip of said lead.

Description

RELATED APPLICATION/S This application claims the benefit of priority under 35 USC §119(e) of U.S. Provisional Patent Application No. 62/307,835 filed 14 March 2016, and Provisional Patent Application No. 62/459,415 filed 15 February 2017 and Provisional Patent Application No. 62/459,422 filed 15 February 2017. In addition, this application is a Continuation in part (CIP) and claims priority of PCT Patent Application No. US2016/031448 filed 9 May 2016. FIELD AND BACKGROUND OF THE INVENTION The present invention, in some embodiments thereof, relates to a brain navigation lead and system and/or parts thereof and, more particularly, but not exclusively, to a brain navigation lead comprising electrode contacts and configured to measure electrical activity of brain tissue. Electric field application to the brain is under increasing use for such varied purposes as treatment of neurological and psychiatric conditions. A typical electrical brain stimulation system comprises a pulse generator operatively connected to the brain by a lead. Prior to electric field application, an electrode is used to determine the desired target location for electric field application. Then, the navigation lead is removed and a second electrode for applying the electric field is inserted. Additional background art includes U.S. Patent application number US2001/014820A1 disclosing a lead for brain stimulation comprising a macro segment having a macro electrode for test stimulation and subsequent chronic stimulation, and a micro segment having a micro electrode for single cell recording. Methods for using the lead to stimulate brain tissue and to identify functional boundaries within brain tissue are also disclosed. SUMMARY OF THE INVENTION The invention provides a system configured for inferring at least one trajectory inside a brain tissue as defined in claim 1. Preferred embodiments of the invention are defined in the dependent claims. Unless otherwise defined, all technical and/or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, exemplary methods and/or materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be necessarily limiting. As will be appreciated by one skilled in the art, some embodiments of the present invention may be embodied as a system, method or computer program product. Accordingly, some embodiments of the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment (including firmware, resident software, micro-code, etc.) or an embodiment combining software and hardware aspects that may all generally be referred to herein as a "circuit," "module" or "system". Furthermore, some embodiments of the present invention may take the form of a computer program product embodied in one or more computer readable medium(s) having computer readable program code embodied thereon. Implementation of the method and/or system of some embodiments of the invention can involve performing and/or completing selected tasks manually, automatically, or a combination thereof. Moreover, according to actual instrumentation and equipment of some embodiments of the method and/or system of the invention, several selected tasks could be implemented by hardware, by software or by firmware and/or by a combination thereof, e.g., using an operating system. For example, hardware for performing selected tasks according to some embodiments of the invention could be implemented as a chip or a circuit. As software, selected tasks according to some embodiments of the invention could be implemented as a plurality of software instructions being executed by a computer using any suitable operating system. In an exemplary embodiment of the invention, one or more tasks according to some exemplary embodiments of method and/or system as described herein are performed by a data processor, such as a computing platform for executing a plurality of instructions. Optionally, the data processor includes a volatile memory for storing instructions and/or data and/or a non-volatile storage, for example, a magnetic hard-disk and/or removable media, for storing instructions and/or data. Optionally, a network connection is provided as well. A display and/or a user input device such as a keyboard or mouse are optionally provided as well. Any combination of one or more computer readable medium(s) may be utilized for some embodiments of the invention. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electronic