EP-4653541-A3 - MODIFIED SIGNAL PEPTIDE
EP4653541A3EP 4653541 A3EP4653541 A3EP 4653541A3EP-4653541-A3
Abstract
A nucleic acid construct includes a polynucleotide encoding a protein of interest and a polynucleotide linked upstream of the polynucleotide and encoding a modified signal peptide. The modified signal peptide includes amino acid residues of X 1 X 2 X 3 X 4 X 5 X 6 at positions 1 to 6 as counted from the C-terminus, where X 1 is G, P, or A; X 2 is G, S, or A; and X 3 is P, S, or A, provided that X 1 X 2 X 3 is not GGP; X 4 is A; X 5 is S, H, or F; and X 6 is A and is located at the C-terminus of the modified signal peptide.
Inventors
- NISHIGUCHI, HIROKI
- KAWAHARA, AKIHITO
Assignees
- KAO CORPORATION
Dates
- Publication Date
- 20260513
- Application Date
- 20211026