EP-4657067-A3 - MOLECULES AND METHODS FOR IMPROVED IMMUNODETECTION OF SMALL MOLECULES, SUCH AS HISTAMINE
EP4657067A3EP 4657067 A3EP4657067 A3EP 4657067A3EP-4657067-A3
Abstract
Embodiments of various aspects described herein are directed to methods, compositions, kits for detecting a target molecule in a sample. In particular, there is described herein a multivalent approach which provides an efficient method for detection of small molecules and screening of binding molecules (e.g., antibodies). The multivalent approach uses two or more small molecules in a domain that is attached to a substrate through a linking group. The multivalent domain is free to extend, e.g., into a solution, for presentation to a binding compound such as an antibody.
Inventors
- JOLLY, Pawan
- MUSTAFAOGLU, Nur
- HENRY, OLIVIER YVES FREDERIC
- INGBER, DONALD E.
Assignees
- President And Fellows Of Harvard College
Dates
- Publication Date
- 20260513
- Application Date
- 20191115