EP-4696334-A3 - FIBROBLAST ACTIVATION PROTEIN TARGETED COMPOUNDS AND USE THEREOF
EP4696334A3EP 4696334 A3EP4696334 A3EP 4696334A3EP-4696334-A3
Abstract
The present invention relates to a fibroblast activation protein alpha (FAP)-targeting conjugate comprising Formula I: Y-L-X, wherein Y is a chelator or cytotoxic drug, L is a linker, and X is a molecule comprising a cyclic peptide of formula A-[Z-AA 1 -AA 2 -AA 3 -AA 4 -AA 5 -AA 6 -AA 7 -Z]-B. A is N-terminal structure. B is C-terminal structure, and each of the Z, AA1, AA2, AA3, AA4, AA5, AA6, AA7 is a residue of an amino acid.
Inventors
- SCHULTZ, MICHAEL K.
- LI, Mengshi
- CAGLE, BRIANNA S.
- BAUMHOVER, Nicholas
- VANCE, IVY
- LIU, DIJIE
- RODMAN, SAMUEL
Assignees
- Perspective Therapeutics, Inc.
Dates
- Publication Date
- 20260506
- Application Date
- 20240501