EP-4696716-A3 - HUMANIZED LIGHT CHAIN MICE
EP4696716A3EP 4696716 A3EP4696716 A3EP 4696716A3EP-4696716-A3
Abstract
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
Inventors
- MACDONALD, LYNN
- GURER, CAGAN
- HOSIAWA, Karolina A
- STEVENS, SEAN
- MURPHY, ANDREW J
Assignees
- Regeneron Pharmaceuticals, Inc.
Dates
- Publication Date
- 20260506
- Application Date
- 20121217