EP-4706763-A3 - ANTI-C5 ANTIBODIES AND USES THEREOF
EP4706763A3EP 4706763 A3EP4706763 A3EP 4706763A3EP-4706763-A3
Abstract
The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.
Inventors
- HU, YING
- LATUSZEK, ADRIANNA
- ROMANO, CARMELO
- OLSON, WILLIAM
Assignees
- Regeneron Pharmaceuticals, Inc.
Dates
- Publication Date
- 20260506
- Application Date
- 20170613