BROADBAND METHOD FOR SIGNAL AMPLIFICATION OF MAGNETIC RESONANCE CONTRAST AGENTS WITHIN SECONDS AND THEIR PURIFICATION

Abstract

The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH 2 ) comprising two protons and at least one heteronucleus (S 3 , S 4 ), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field ( B 0 ) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group ( N A , N B , N C ) of 180° radio frequency pulses, wherein the first group ( N A ) of 180° radio frequency pulses is consecutively applied n A times during a first time interval ( τ 4 ) and wherein the second group ( N B ) of 180° radio frequency pulses is consecutively applied n B times during a second time interval ( τ B ) after the last first group, and wherein the third group ( N C ) of 180° radio frequency pulses is consecutively applied n C times during a third time interval ( τ C ) after the last second group, wherein n A , n B , n C are integer numbers, respectively.

Inventors

Glöggler, Stefan
KORCHAK, SERGEY
MAMONE, Salvatore

Assignees

Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Dates

Publication Date: 20260506
Application Date: 20220826