EP-4729947-A3 - CRISPR/CAS SCREENING PLATFORM TO IDENTIFY GENETIC MODIFIERS OF TAU SEEDING OR AGGREGATION
EP4729947A3EP 4729947 A3EP4729947 A3EP 4729947A3EP-4729947-A3
Abstract
Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic modifiers of tau seeding or aggregation are provided. Reagents and methods for sensitizing such cells to tau seeding activity or tau aggregation or for causing tau aggregation are also provided.
Inventors
- PRISSETTE, Marine
- KOSS, MATTHEW
- FURY, WEN
- ZAMBROWICZ, BRIAN
Assignees
- Regeneron Pharmaceuticals, Inc.
Dates
- Publication Date
- 20260506
- Application Date
- 20200317