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EP-4734910-A1 - HYPOCHLOROUS ACID-BASED EYELID CLEANSERS

EP4734910A1EP 4734910 A1EP4734910 A1EP 4734910A1EP-4734910-A1

Abstract

An antimicrobial eyelid cleanser composition contains hypochlorous acid, sodium acetate and purified water. The composition has a free available chlorine (FAC) concentration of from about 10 ppm - 300 ppm, an osmolality of 40-200 mOsm/kg and a viscosity of 1 cP - 500 cP. The composition has a pH from about 3.5 - 6.5. The eyelid cleanser composition is an ophthalmic or ocular composition that can clean the eyelids and eyes and remove excessive oil, debris, and desquamated skin from the eyelids and surrounding areas while reducing inflammation and promoting wound healing.

Inventors

  • SARKAR, Paramita

Assignees

  • Ocusoft, Inc.

Dates

Publication Date
20260506
Application Date
20240627

Claims (12)

  1. 1. An eyelid cleanser composition comprising: 0.005 to 0.05 wt. % hypochlorous acid; 0.001 to 2.0 wt. % sodium acetate; and purified water q.s. up to 100 % w/w, wherein the composition has a free available chlorine (FAC) concentration of from about 10 ppm - 300 ppm.
  2. 2. The eyelid cleanser composition according to claim 1, wherein the composition further comprises 0.05 wt. % to 0.75 wt. % sodium lauryl sulfate or sodium laureth sulfate.
  3. 3. The eyelid cleanser composition according to claim 2, wherein the composition further comprises 0.001 wt. % to 2.0 wt. % acetic acid.
  4. 4. The eyelid cleanser composition according to claim 1, wherein the composition further comprises 0.05 wt. % to 0.75 wt. % capryl/caprylyl glucoside.
  5. 5. The eyelid cleanser composition according to claim 4, wherein the composition further comprises 0.05 wt. % to 1.0 wt. % propylene glycol.
  6. 6. The eyelid cleanser composition according to claim 5, wherein the composition further comprises 0.001 wt. % to 2.0 wt. % acetic acid.
  7. 7. The eyelid cleanser composition according to claim 6, wherein the composition further comprises 0.05 wt. % to 5.0 wt. % medium chain alkanes.
  8. 8. The eyelid cleanser composition according to claim 1, wherein the composition further comprises 0.05 wt. % to 0.75 wt. % dioctyl sodium sulfocsuccinate.
  9. 9. The eyelid cleanser composition according to claim 8, wherein the composition further comprises 0.001 wt. % to 2.0 wt. % acetic acid.
  10. 10. The eyelid cleanser composition according to claim 1, wherein the composition has an osmolality of 40-200 mOsm/kg.
  11. 11. The eyelid cleanser composition according to claim 1, wherein the composition has a viscosity of 1 cP-500 cP.
  12. 12. The eyelid cleanser composition according to claim 1, wherein the composition has a pH from about 3.5 - 6.5.

Description

HYPOCHLOROUS ACID-BASED EYELID CLEANSERS FIELD OF THE INVENTION [0001] The present invention relates generally to eyelid and skin cleaning compositions and to methods of preparing and using such compositions. BACKGROUND [0002] Ocular health includes not only the eyes themselves but also related structures, such as the eyelids. Playing a crucial role in maintaining overall eye health, eyelids protect the eyes from potential dangers like approaching objects and airborne contaminants, including pollen, dust, and other foreign substances. Eyelids house important glands, the lacrimal and meibomian glands, which produce layers of tear film essential for maintaining healthy eyes. Blinking forms a new layer of tear film and spreads tears evenly across the cornea, lubricating the eye's surface. Furthermore, this blinking action helps remove foreign materials from the eye. [0003] Eyelid issues, although common, can be particularly troublesome for contact lens wearers and may potentially lead to more severe complications. One notable complication is blepharitis, which is a chronic inflammatory condition of the eyelids, characterized by a scaly crust along the lid margins. The underlying causes of blepharitis may include bacterial infections, allergies, or even an association with facial and scalp seborrhea. Effective treatment generally entails frequent eyelid cleansing to eliminate excess oil, debris, and desquamated skin, which could otherwise exacerbate the problem. [0004] Blepharitis, an inflammation of the eyelid, is often accompanied by or secondary to an internal hordeolum, a bacterial infection affecting the skin's surface at the edge of the eyelid. Another related infection is an external hordeolum, more commonly known as a stye, which targets the small oil-secreting meibomian glands along the eyelid's edge, encircling the eyelashes. Styes usually manifest as red, tender bumps that fully develop within three days and are characterized by pain, redness, and tenderness of the eyelid margins. Regularly cleansing the eyelid margins can help minimize the occurrence of these often-recurring conditions. A chalazion, which is an inflammation of the meibomian glands inside the eyelid, is another issue to consider. Chalazia typically grow slowly over 2-3 weeks, and although they are not generally painful, they may necessitate surgical intervention if left untreated. [0005] Enhancing eyelid hygiene with the use of cleansers can mitigate the severity of various problems, such as the ones mentioned earlier, and other medical complications like rosacea and seborrhea. By addressing these issues early, it may be possible to prevent them altogether. Eyelid cleansers serve a dual purpose, as they are effective in cleaning not only eyelashes and eyelids, but also the periocular area. Furthermore, they can be employed as a pre-operative scrub to diminish the presence of harmful bacteria, thus reducing the likelihood of infection, inflammation, or endophthalmitis in patients. SUMMARY [0006] According to an embodiment, the eyelid cleanser composition includes: from about 0.005 to about 0.05 wt. % hypochlorous acid; from about 0.001 to 2.0 wt. % sodium acetate; and purified water q.s. up to 100 % w/w. The composition has a free available chlorine (FAC) concentration of from about 10 ppm - 300 ppm. The composition has an osmolality of 40-200 mOsm/kg and a viscosity of 1 cP-500 cP. The composition has a pH from about 3.5 - 6.5. [0007] According to an embodiment, the composition further includes from about 0.05 wt. % to about 0.75 wt. % sodium lauryl sulfate or sodium laureth sulfate and from about 0.001 wt. % to about 2.0 wt.% acetic acid. [0008] According to another embodiment, the composition further comprises from about 0.05 wt. % to 0.75 wt. % capryl/caprylyl glucoside, from about 0.05 wt. % to about 1.0 wt. % propylene glycol, from about 0.001 wt. % to 2.0 wt. % acetic acid, from about 0.05 wt. % to about 5.0 wt. % medium chain alkanes. [0009] According to yet another embodiment, the composition further comprises from about 0.05 wt. % to about 0.75 wt. % dioctyl sodium sulfocsuccinate, and from about 0.001 wt. % to about 2.0 wt. % acetic acid. DETAILED DESCRIPTION [0010] The term and phrases "invention," "present invention," "instant invention," and similar terms and phrases as used herein are non-limiting and are not intended to limit the present subject matter to any single embodiment, but rather encompass all possible embodiments as described. [0011] As used herein, all weight percentages (wt. %) are based on the total wt. % of the skin care composition, unless otherwise specified. Additionally, all composition percentages are based on totals equal to 100 wt. %, unless otherwise specified. [0012] The compositions and methods for their use can "comprise," "consist essentially of," or "consist of any of the ingredients or steps disclosed throughout the specification. As used in this specification and claim(s), the words "co