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EP-4734922-A2 - ORAL CARE COMPOSITIONS COMPRISING HOPS BETA ACIDS AND TIN

EP4734922A2EP 4734922 A2EP4734922 A2EP 4734922A2EP-4734922-A2

Abstract

An oral care composition includes hops beta acid, a stannous ion source, a monodentate ligand, and one or more polydentate ligands. The oral care composition may have an improved soluble stannous concentration.

Inventors

  • ST. JOHN, SAMUEL, JAMES
  • BAIG, ARIF, ALI

Assignees

  • The Procter & Gamble Company

Dates

Publication Date
20260506
Application Date
20240627

Claims (15)

  1. CLAIMS What is claimed is: 1. An oral care composition comprising: hops beta acid; a stannous ion source; and one or more polydentate ligands, wherein the one or more polydentate ligands comprises citrate, wherein the oral care composition is free of gluconate.
  2. 2. The oral care composition of claim 1, wherein the stannous ion source comprises stannous fluoride, stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous oxalate, stannous sulfate, stannous sulfide, stannic fluoride, stannic chloride, stannic bromide, stannic iodide, stannic sulfide, or combinations thereof.
  3. 3. The oral care composition of claim 1 or 2, wherein the composition has a soluble stannous concentration of about 700 ppm or greater, preferably about 800 ppm or greater, preferably about 1,000 ppm or greater, or more preferably about 2,000 ppm or greater.
  4. 4. The oral care composition of any one of the preceding claims, wherein the composition has a soluble stannous concentration of from about 700 ppm to about 3,500 ppm.
  5. 5. The oral care composition of any one of the preceding claims, wherein the oral care composition has an improved soluble stannous concentration than the composition without the hops beta acid.
  6. 6. The oral care composition of any one of the preceding claims, wherein the one or more polydentate ligands further comprises EDTA, phytate, or a combination thereof.
  7. 7. The oral care composition of any one of the preceding claims, wherein the one or more polydentate ligands consists essentially of citrate.
  8. 8. The oral care composition of any one of the preceding claims, further comprising an abrasive, the abrasive comprising a silica abrasive or a calcium abrasive, preferably wherein the abrasive comprises calcium abrasive, more preferably wherein the calcium abrasive comprises calcium carbonate.
  9. 9. The oral care composition of any one of the preceding claims, wherein the oral care composition is free of silica, free of fluoride, or a combination thereof.
  10. 10. The oral care composition of any one of claims 1-9, further comprising a fluoride ion source.
  11. 11. The oral care composition of any one of the preceding claims, further comprising from about 0.01% to about 10%, by weight of the composition, of a metal ion source, preferably wherein the metal ion source comprises a zinc ion source.
  12. 12. The oral care composition of any one of the preceding claims, wherein the hops beta acid comprises only non-hydrogenated hops beta acid.
  13. 13. The oral care composition of any one of the preceding claims, wherein the oral care composition comprises from about 0.05% to about 10%, preferably from about 0.05% to about 5%, or more preferably from about 0.05% to about 2%, by weight of the composition, of the hops beta acid.
  14. 14. The oral care composition of any one of the preceding claims, wherein the oral care composition comprises from about 0.5% to about 20%, preferably from about 0.5% to about 10%, or more preferably from about 1% to about 5%, by weight of the composition, of the one or more polydentate ligands.
  15. 15. An oral care composition comprising: hops beta acid; a stannous ion source; silica; and a stannous-stabilizing ligand comprising a monodentate ligand or one or more polydentate ligands, wherein a pH of the oral care composition is from about 6 to about 8.

Description

ORAL CARE COMPOSITIONS COMPRISING HOPS BETA ACIDS AND TIN TECHNICAL FIELD The disclosure relates generally to oral care compositions, and more particularly relates to oral care compositions comprising hops and stannous with improved stannous availability. BACKGROUND Oral care compositions, such as toothpaste and/or dentifrice compositions, can be applied to the oral cavity to clean and/or maintain the aesthetics and/or health of the teeth, gums, and/or tongue. Additionally, many oral care compositions are used to deliver active ingredients directly to oral care surfaces. For example, toothpaste compositions can include cationic antimicrobial agents, such as a metal ion source, such as tin, copper, and/or zinc and/or cetylpyridinium chloride. They can also include fluoride for the prevention of cavities. Stannous fluoride provides both a metal ion and fluoride for the protection of teeth and gums. However, stannous sources can be challenging to properly formulate in oral care compositions due to reactivity between stannous and other components of oral care compositions. Under-stabilizing or over-stabilizing stannous can lead to lower availability of stannous ions to provide the desired benefit. For example, if the stannous is under-stabilized, the stannous can react with other components of the oral care composition, such as silica, water, etc., which can lead to a lower amount of available stannous ions. Additionally, the remaining under-stabilized stannous, when delivered to the oral cavity, may be hyper-reactive with different oral surfaces, thus impeding the action of other ingredients or causing excess stain. In contrast, if the stannous is over-stabilized or the chelant-stannous interaction is too strong, stannous ions will be tied up when delivered to the oral cavity, which can also lead to a lower amount of bioavailable stannous ions to produce the desired oral care benefit. As such, there is a need for oral care compositions comprising a high amount of available stannous ions that are optimally bioavailable for the desired product benefit. SUMMARY An oral care composition is provided and includes hops beta acid, a stannous ion source, a monodentate ligand, and one or more polydentate ligands. DETAILED DESCRIPTION Embodiments of the present invention are directed to oral care compositions with a stannous-chelant-hops and/or stannous-ligand-hops interaction that results in an improved soluble stannous concentration. For example, embodiments of the present invention provide improved soluble stannous of the oral care composition. Such an achievement was realized with the discovery of the ability of hops beta acid to improve the solubility of stannous ions in formulas comprising both stannous and hops beta acids. Definitions To define more clearly the terms used herein, the following definitions are provided. Unless otherwise indicated, the following definitions are applicable to this disclosure. If a term is used in this disclosure but is not specifically defined herein, the definition from the IUPAC Compendium of Chemical Terminology, 2nd Ed (1997), can be applied, as long as that definition does not conflict with any other disclosure or definition applied herein, or render indefinite or non-enabled any claim to which that definition is applied. The term "oral care composition", as used herein, includes a product, which in the ordinary course of usage, is not intentionally swallowed for purposes of systemic administration of particular therapeutic agents, but is rather retained in the oral cavity for a time sufficient to contact dental surfaces or oral tissues. Examples of oral care compositions include dentifrice, toothpaste, tooth gel, subgingival gel, emulsion, mouth rinse, mousse, foam, mouth spray, lozenge, chewable tablet, chewing gum, tooth whitening strips, floss and floss coatings, breath freshening dissolvable strips, unit-dose composition, fibrous composition, or denture care or adhesive product. The oral care composition may also be incorporated onto strips or films for direct application or attachment to oral surfaces, such as tooth whitening strips. Examples of emulsion compositions include the emulsions compositions of U.S. Patent No.11,147,753, jammed emulsions, such as the jammed oil-in-water emulsions of U.S. Patent No. 11,096,874. Examples of unit-dose compositions include the unit-dose compositions of U.S. Patent Application Publication No.2019/0343732. The term "dentifrice composition", as used herein, includes tooth or subgingival -paste, gel, or liquid formulations unless otherwise specified. The dentifrice composition may be a single- phase composition or may be a combination of two or more separate dentifrice compositions. The dentifrice composition may be in any desired form, such as deep striped, surface striped, multilayered, having a gel surrounding a paste, or any combination thereof. Each dentifrice composition in a dentifrice comprising two or more separate dentifrice