EP-4734927-A1 - METHODS OF USING A SKINCARE COMPOSITION

Abstract

Provided are methods of treating skin using skincare compositions comprising (a) an emollient; (b) an occlusive; (c) a humectant; (d) a processed oat ingredient; (e) a rheological modifier; and (f) water.

Inventors

• MACIEL, Gabriel
• LOPES DE JESUS, Lais
• TORRACA, Juliana
• RENNO, Isabelle
• CARNEIRO, Tamara
• MIOTTO, Juliana

Assignees

• Kenvue Brands LLC

Dates

Publication Date

20260506

Application Date

20240628

Claims (20)

1. 1. A method of treating eczema, the method comprising topically applying to skin afflicted with eczema a composition comprising: a. an emollient; b. an occlusive; c. a humectant; d. a processed oat ingredient; and e. a rheological modifier; and f. water.
2. 2. The method of claim 1 , wherein treating eczema comprises a method of reducing Global SCORAD.
3. 3. The method of claim 1, wherein treating eczema comprises a method of reducing the severity of eczema as measured by the POEM questionnaire.
4. 4. The method of claim 1 , wherein treating eczema comprises a method of increasing skin hydration.
5. 5. The method of claim 1, wherein treating eczema comprises a method of reducing S. aureus in the skin microbiome.
6. 6. The method of claim 1 , wherein treating eczema comprises a method of increasing S. epidermidis in the skin microbiome.
7. 7. The method of claim 1, wherein treating eczema comprises a method of increasing the quality of life of a person having eczema.
8. 8. The skincare composition of claim 1, wherein the rheological modifier comprises hydroxypropyl starch phosphate.
9. 9. The skincare composition of claim 1, wherein the rheological modifier is present in an amount of from about 0.25% to about 2.5%.
10. 10. The skincare composition of claim 1, wherein the emollient is selected from the group consisting of esters; silicone-con taining compounds; plant, nut, and vegetable oils and butters; and combinations thereof.
11. 11. The skincare composition of claim 1 , wherein the emollient is selected from the group consisting of isopropyl palmitate, dimethicone, helianthus annus seed oil, and combinations thereof.
12. 12. The skincare composition of claim 1, wherein the occlusive comprises petrolatum.
13. 13. The skincare composition of claim 1, wherein the occlusive is present in an amount ranging from about 1 to about 8 wt.% by total weight of the composition.
14. 14. The skincare composition of claim 1, wherein the humectant comprises glycerin.
15. 15. A method of treating eczema, the method comprising topically applying to skin afflicted with eczema a composition comprising: a. about 2 to about 10 wt. % of an emollient is selected from the group consisting of isopropyl palmitate, dimethicone, helianthus annus seed oil, and combinations thereof; b. about 1 to about 8 wt. % of an occlusive comprising petrolatum; c. about 0.5 to about 20 wt. % of a humectant comprising glycerin; d. about 0.1 to about 3 wt. % of a processed oat ingredient; and e. about 0.1 to about 3 wt. % of a rheological modifier comprising hydroxypropyl starch phosphate.
16. 16. The method of claim 15, wherein treating eczema comprises a method of reducing Global SCORAD.
17. 17. The method of claim 15, wherein treating eczema comprises a method of reducing the severity of eczema as measured by the POEM questionnaire.
18. 18. The method of claim 15, wherein treating eczema comprises a method of increasing skin hydration.
19. 19. The method of claim 15, wherein treating eczema comprises a method of reducing S. aureus in the skin microbiome.
20. 20. The method of claim 15, wherein treating eczema comprises a method of increasing S. epidermidis in the skin microbiome.

Description

METHODS OF USING A SKINCARE COMPOSITION FIELD The present invention generally relates to compositions for suitable for use on skin afflicted with atopic dermatitis. More specifically, the present invention relates to methods of using skincare compositions on skin afflicted with atopic dermatitis. BACKGROUND Atopic dermatitis, also known as eczema, is a chronic relapsing pruritic inflammation of the skin that can compromise quality of life. Atopic dermatitis affects 10-20% of children and 1-3% of adults worldwide with increasing prevalence in highly industrialized countries. Atopic dermatitis is characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection. Because it has a complex pathogenesis, atopic dermatitis can also present several types of therapeutic management according to its characteristics and severity. Basic therapy involves appropriate mild skin hygiene and daily use of moisturizers to maintain and restore the integrity of the skin barrier and increase the water content of the stratum comeum. Topical or oral corticosteroids, which act on the immune system by blocking the production of substances that trigger allergic and inflammatory actions, remain the first-line treatments. Similarly, antihistamine can also be administrated. If pruritus does not respond to standard treatments, antibiotics might be considered. Moisturizers are effective in keeping the skin hydrated and repairing the skin barrier. However, the cosmetic acceptance of these types of formulations may be poor which is reflected in a lower compliance among the atopic dermatitis patients. Moreover, this approach is often not sufficient by itself. Corticosteroids on the other hand are powerful medications but are known to induce side effects, some of which might be severe in case of long term usage. While antihistamine can be used to treat itch associated with atopic dermatitis, they can cause sleepiness and may not help in all cases of atopic dermatitis. Finally, the use of antibiotics is controversial due to the raising occurrence of bacterial resistance. Additionally, a treatment will ideally address the visual appearance of skin afflicted with eczema, and/or otherwise provide other benefits perceived by the user. However, traditional ingredients are often too harsh for use on the sensitive skin of individuals with eczema. Accordingly, there exists a need for topical compositions which are suitable for use on eczematic skin and can address one or more of the concerns above. SUMMARY One aspect of the invention pertains to a method of treating eczema, the method comprising topically applying to skin afflicted with eczema a composition comprising: a. an emollient; b. an occlusive; c. a humectant; d. a processed oat ingredient; and e. a rheological modifier; and f. water. In one or more embodiments, treating eczema comprises a method of reducing Global SCORAD. In some embodiments, treating eczema comprises a method of reducing the severity of eczema as measured by the POEM questionnaire. In one or more embodiments, treating eczema comprises a method of increasing skin hydration. In some embodiments, treating eczema comprises a method of reducing S. aureus in the skin microbiome. In one or more embodiments, treating eczema comprises a method of increasing S. epidermidis in the skin microbiome. In some embodiments, treating eczema comprises a method of increasing the quality of life of a person having eczema. In one or more embodiments, the rheological modifier comprises hydroxypropyl starch phosphate. In some embodiments, the rheological modifier is present in an amount of from about 0.25% to about 2.5%. In one or more embodiments, the emollient is selected from the group consisting of esters; silicone-con taining compounds; plant, nut, and vegetable oils and butters; and combinations thereof. In some embodiments, the emollient is selected from the group consisting of isopropyl palmitate, dimethicone, helianthus annus seed oil, and combinations thereof. In one or more embodiments, the occlusive comprises petrolatum. In some embodiments, the occlusive is present in an amount ranging from about 1 to about 8 wt.% by total weight of the composition. In one or more embodiments, the humectant comprises glycerin. Another aspect of the invention pertains to a method of treating eczema, the method comprising topically applying to skin afflicted with eczema a composition comprising: a. about 2 to about 10 wt. % of an emollient is selected from the group consisting of isopropyl palmitate, dimethicone, helianthus annus seed oil, and combinations thereof; b. about 1 to about 8 wt. % of an occlusive comprising petrolatum; c. about 0.5 to about 20 wt. % of a humectant comprising glycerin; d. about 0.1 to about 3 wt. % of a processed oat ingredient; and e. about 0.1 to about 3 wt. % of a rheological modifier comprising hydroxypropyl starch phosphate.