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EP-4734934-A1 - PERSONAL CARE COMPOSITION BASED ON CARBOXYMETHYL CYSTEIN COMPOUND AND CAROTENOID OR ESTER THEREOF

EP4734934A1EP 4734934 A1EP4734934 A1EP 4734934A1EP-4734934-A1

Abstract

Disclosed is a personal care composition comprising carboxymethyl cysteine compound and carotenoid compound, wherein the carotenoid compound is selected from carotenoid and ester thereof, wherein the weight ratio of the carboxymethyl cysteine compound to the carotenoid compound is in the range of 40:1 to 1:25.

Inventors

  • GU, Xuelan
  • XIAO, XUE

Assignees

  • Unilever IP Holdings B.V.
  • UNILEVER GLOBAL IP LIMITED

Dates

Publication Date
20260506
Application Date
20240621

Claims (14)

  1. 1. A personal care composition comprising carboxymethyl cysteine compound and carotenoid compound, wherein the carotenoid compound is selected from carotenoid and ester thereof, wherein the weight ratio of the carboxymethyl cysteine compound to the carotenoid compound is in the range of 40:1 to 1 :25.
  2. 2. The composition according to claim 1 wherein the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and/or salt of carboxymethyl cysteine.
  3. 3. The composition according to claim 2 wherein the carboxymethyl cysteine compound comprises salt of carboxymethyl cysteine and preferably the carboxymethyl cysteine compound comprises lysine carboxymethyl cysteinate.
  4. 4. The composition according to any one of the preceding claims wherein the carboxymethyl cysteine compound is present in amount of at least 0.00001% and no greater than 10% by weight of the composition, preferably carboxymethyl cysteine compound is present in amount of at least 0.01% and no greater than 3% by weight of the composition.
  5. 5. The composition according to any one of the preceding claims wherein the carotenoid compound is selected from astaxanthin, zeaxanthin, lutein, cryptoxanthin, capsanthin, actinioerythrol and esters thereof, preferably the carotenoid compound is selected from astaxanthin and esters thereof.
  6. 6. The composition according to any one of the preceding claims wherein the carotenoid compound is present in amount of at least 0.00001 % and no greater than 2% by weight of the composition.
  7. 7. The composition according to any one of the preceding claims wherein the weight ratio of the carboxymethyl cysteine compound to the carotenoid compound is in the range of 40:1 to 1 :10, preferably in the range of 5: 1 to 1 : 1.
  8. 8. The composition according to any one of the preceding claims wherein the weight ratio of the carboxymethyl cysteine compound to total astaxanthin and ester of astaxanthin is in the range of 40: 1 to 1 : 10, preferably in the range of 5: 1 to 1 : 1.
  9. 9. The composition according to any one of the preceding claims wherein the composition is an emulsion, preferably an oil-in-water emulsion.
  10. 10. The composition according to any one of the preceding claims wherein the composition is a fluid liquid at 25 °C and atmospheric pressure.
  11. 11 . The composition according to any one of the preceding claims wherein the composition comprises water in amount of 10 to 96% by weight of the composition, preferably from 42 to 88% by weight of the composition.
  12. 12. A method of providing the skin benefits selected from the group consisting of enhancing collagen production in the skin, improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of collagen synthesizing gene comprising a step of topically applying to the skin the composition of any one of the preceding claims.
  13. 13. Use of the composition of any one of the preceding claims 1 to 11 for providing the skin benefits selected from the group consisting of enhancing collagen production in the skin, improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of collagen synthesizing gene.
  14. 14. Use of carotenoid compound wherein the carotenoid compound is selected from carotenoid and ester thereof, for providing the skin benefits selected from the group consisting of enhancing collagen production in the skin, improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of collagen synthesizing gene.

Description

PERSONAL CARE COMPOSITION BASED ON CARBOXYMETHYL CYSTEIN COMPOUND AND CAROTENOID OR ESTER THEREOF Field of the Invention The present invention relates to a personal care composition comprising carboxymethyl cysteine compound and carotenoid compound, wherein the carotenoid compound is selected from carotenoid and ester thereof. It was unexpectedly found that the expression of collagen type I alpha I chain was significantly enhanced by such composition. Background of the Invention The skin is a primary barrier of the human body. It protects the organs in the body from external stimulations. It is subject to intrinsic aging and extrinsic aging. Skin aging is a complex process, and alterations in human skin due to aging have distinct characteristics as compared to other organs. Characteristics of intrinsic or chronological skin aging include dryness, visible free lines and wrinkles, uneven skin pigmentation, loss of elasticity and skin sagging. Extrinsic factors including exposure to sunlight, pollutants and cigarette smoke can accelerate the skin aging process, especially on the face. Collagen, the predominant matrix of the skin protein, is known to impart tensile strength to skin. It has been shown that collagen is significantly reduced with age and UV exposure. The degradation or destruction of the architecture of collagen decreases the tensile strength of the skin and therefore causing wrinkles and laxity. Collagen destruction is thought to underlie the characteristic alterations in the appearance of aged skin. One of the most efficient ways for providing the effect of anti-aging is to promote the production of collagen. Upregulating the expression of collagen synthesizing genes typically leads to an increase in collagen production. Therefore, the present inventors have recognized that there is a need to develop solution to enhance the expression of collagen synthesizing genes, for example collagen type I alpha I chain (COL1A 1). It was surprisingly found that by combining carboxymethyl cysteine compound and carotenoid compound, wherein the carotenoid compound is selected from carotenoid and ester thereof and the weight ratio of the carboxymethyl cysteine compound to the carotenoid compound is in the range of 40:1 to 1 :25, the expression of COL1A1 was significantly upregulated. of the Invention In a first aspect, the present invention is directed to a personal care composition comprising a personal care composition comprising carboxymethyl cysteine compound and carotenoid compound, wherein the carotenoid compound is selected from carotenoid and ester thereof, wherein the weight ratio of the carboxymethyl cysteine compound to the carotenoid compound is in the range of 40:1 to 1 :25. In a second aspect, the present invention is directed to a method of providing the skin benefits selected from the group consisting of enhancing collagen production in the skin, improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of collagen synthesizing gene comprising a step of topically applying to the skin the composition of the composition of the present invention. In a third aspect, the present invention is directed to use of the composition of the present invention for providing the skin benefits selected from the group consisting of enhancing collagen production in the skin, improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of collagen synthesizing gene. All other aspects of the present invention will more readily become apparent upon considering the detailed description and examples which follow. Detailed Description of the Invention Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use may optionally be understood as modified by the word “about”. All amounts are by weight of the composition, unless otherwise specified. It should be noted that in specifying any range of values, any particular upper value can be associated with any particular lower value. For the avoidance of doubt, the word “comprising” is intended to mean “including” but not necessarily “consisting of’ or “composed of’. In other words, the listed steps or options need not be exhaustive. The disclosure of the invention as found herein is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy. Where a feature is disclosed with respect to a particular aspect of the invention (for example a composition of the invention), such disclosure is also to be considered to apply to any other aspect of the invention (for example a method of the invention) mutatis mutandis. The carboxymethyl cysteine compound refers to compound sel