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EP-4734943-A1 - PERSONAL CARE COMPOSITION COMPRISING A CARBOXYMETHYL CYSTEINE COMPOUND AND A SILYMARIN COMPOUND

EP4734943A1EP 4734943 A1EP4734943 A1EP 4734943A1EP-4734943-A1

Abstract

Disclosed is a personal care composition comprising carboxymethyl cysteine compound and silymarin compound, wherein the silymarin compound is selected from silymarin, silybin, isosilybin, silydianin, silychristin, silandrin, silymonin, neosilyhermin, salt and ester thereof, and a combination thereof.

Inventors

  • GU, Xuelan
  • XIAO, XUE

Assignees

  • Unilever IP Holdings B.V.
  • UNILEVER GLOBAL IP LIMITED

Dates

Publication Date
20260506
Application Date
20240603

Claims (12)

  1. 1. A personal care composition comprising carboxymethyl cysteine compound and silymarin compound, wherein the silymarin compound is selected from silymarin, silybin, isosilybin, silydianin, silychristin, silandrin, silymonin, neosilyhermin, salt and ester thereof, and a combination thereof.
  2. 2. The composition according to claim 1 wherein the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and/or salt of carboxymethyl cysteine.
  3. 3. The composition according to claim 2 wherein the carboxymethyl cysteine compound comprises salt of carboxymethyl cysteine and preferably the carboxymethyl cysteine compound comprises lysine carboxymethyl cysteinate.
  4. 4. The composition according to any one of the preceding claims wherein the carboxymethyl cysteine compound is present in amount of at least 0.00001% and no greater than 10% by weight of the composition, preferably carboxymethyl cysteine compound is present in amount of at least 0.01% and no greater than 3% by weight of the composition.
  5. 5. The composition according to any one of the preceding claims wherein the silymarin compound is selected from silybin, isosilybin, salt and ester thereof, and a combination thereof, preferably the silymarin compound is silybin.
  6. 6. The composition according to any one of the preceding claims wherein the silymarin compound is present in amount of 0.001 to 2%, preferably 0.1 to 0.5% by weight of the composition.
  7. 7. The composition according to any one of the preceding claims wherein the molar ratio of the carboxymethyl cysteine compound to the total silymarin compound is 1:2 to 50:1 , preferably 3:1 to 8:1.
  8. 8. The composition according to any one of the preceding claims wherein the composition is an emulsion, preferably an oil-in-water emulsion.
  9. 9. The composition according to any one of the preceding claims wherein the composition is a fluid liquid at 25 °C and atmospheric pressure.
  10. 10. The composition according to any one of the preceding claims wherein the composition comprises water in amount of 10 to 96% by weight of the composition, preferably from 42 to 88% by weight of the composition.
  11. 11. A method of providing the skin benefits selected from the group consisting of reducing the appearance of wrinkles, reducing sagging, anti-aging, antioxidant and oxidative stress reduction comprising a step of topically applying to the skin the composition of any one of the preceding claims.
  12. 12. Use of the composition of any one of the preceding claims 1 to 11 for providing the skin benefits selected from the group consisting of reducing the appearance of wrinkles, reducing sagging, anti-aging, antioxidant and oxidative stress reduction.

Description

PERSONAL CARE COMPOSITION COMPRISING A CARBOXYMETHYL CYSTEINE COMPOUND AND A SILYMARIN COMPOUND Field of the Invention The present invention relates to a personal care composition comprising carboxymethyl cysteine compound and silymarin compound. It was unexpectedly found that such composition is capable of significantly synergistically elevating the expression of ATG5 (Autophagy related Gene 5) gene. Background of the Invention The skin is a primary barrier of the human body and protects the organs in the body from stimulation caused by external environments such as ultraviolet rays, pollutants, temperature and etc. It is subject to intrinsic aging and extrinsic aging. Skin aging is a complex process, and alterations in human skin due to aging have distinct characteristics as compared to other organs. Characteristics of intrinsic or chronological skin aging include dryness, visible free lines and wrinkles, uneven skin pigmentation, loss of elasticity and skin sagging. Extrinsic factors including exposure to sunlight, pollutants and cigarette smoke can accelerate the skin aging process, especially on the face. Autophagy is now considered critical in controlling skin aging because it plays an important role in degradation of abnormal proteins accumulated in cells, unnecessary intracellular organelles, pathogenic microorganisms. In addition, autophagy has been shown to regulate color, homeostasis, and functions of keratinocytes, skin dermal fibroblasts, and melanocytes to promote skin aging. ATG5 (Autophagy related Gene 5) is one of the major autophagy-modulating genes. Therefore, the present inventors have recognized there are needs to develop a personal care composition which is capable of upregulating the expression of ATG5, to activate the autophagy of cells of the skin. It was surprisingly found that the combination of carboxymethyl cysteine compound and silymarin compound exhibits synergistic effects for upregulating the expression of ATG5 gene. Summary of the Invention In a first aspect, the present invention is directed to a personal care composition comprising carboxymethyl cysteine compound and silymarin compound, wherein the silymarin compound is selected from silymarin, silybin, isosilybin, silydianin, silychristin, silandrin, silymonin, neosilyhermin, salt and ester thereof, and a combination thereof. In a second aspect, the present invention is directed to a method of providing the skin benefits selected from the group consisting of improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of autophagy related gene 5 comprising a step of topically applying to the skin the composition of the present invention. In a third aspect, the present invention is directed to use of the composition of the present invention for providing the skin benefits selected from the group consisting of improving skin elasticity, reducing the appearance of wrinkles, reducing sagging, anti-aging and upregulating the expression of autophagy related gene 5. All other aspects of the present invention will more readily become apparent upon considering the detailed description and examples which follow. Detailed Description of the Invention Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use may optionally be understood as modified by the word “about”. All amounts are by weight of the composition, unless otherwise specified. It should be noted that in specifying any range of values, any particular upper value can be associated with any particular lower value. For the avoidance of doubt, the word “comprising” is intended to mean “including” but not necessarily “consisting of’ or “composed of’. In other words, the listed steps or options need not be exhaustive. The disclosure of the invention as found herein is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy. Where a feature is disclosed with respect to a particular aspect of the invention (for example a composition of the invention), such disclosure is also to be considered to apply to any other aspect of the invention (for example a method of the invention) mutatis mutandis. The carboxymethyl cysteine compound refers to compound selected from carboxymethyl cysteine, salt of carboxymethyl cysteine, ester of carboxymethyl cysteine, amide of carboxymethyl cysteine or a mixture thereof. Preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, ester of carboxymethyl cysteine, and/or salt of carboxymethyl cysteine. More preferably, the carboxymethyl cysteine compound comprises carboxymethyl cysteine, and/or salt of carboxymethyl cysteine. Even more preferably, carboxymethyl cysteine compound