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EP-4736177-A1 - TREATMENT PLANNING FOR DELIVERING TUMOR TREATING FIELDS USING PATIENT DATA

EP4736177A1EP 4736177 A1EP4736177 A1EP 4736177A1EP-4736177-A1

Abstract

A method for treatment planning for delivering tumor treating fields to a subject, the method comprising: obtaining a plurality of treatment locations for delivering tumor treating fields to a subject, each treatment location comprising a plurality of transducer locations for delivering tumor treating fields to the subject; for each treatment location, locating a plurality of transducers on the subject, wherein each transducer is located on the subject according to a respective transducer location for the treatment location; delivering tumor treating fields to the subject using the transducers located on the subject; recording data from delivering tumor treating fields to the subject; and removing the plurality of transducers from the subject; and selecting at least one of the treatment locations for further delivering tumor treating fields to the subject.

Inventors

  • SHAMIR, REUVEN RUBY
  • ARVATZ, Smadar
  • PELES ZEEVI, Oren
  • SHAPIRA, Nadav

Assignees

  • Novocure GmbH

Dates

Publication Date
20260506
Application Date
20240618

Claims (15)

  1. 1. A computer-implemented method for treatment planning for delivering tumor treating fields to a subject, the method comprising: obtaining a plurality of treatment locations for delivering tumor treating fields to a subject, each treatment location comprising a plurality of transducer locations for delivering tumor treating fields to the subject; for each treatment location, delivering tumor treating fields to the subject using transducers located on the subject; and recording data from delivering tumor treating fields to the subject; and selecting, based on the data recorded from delivering tumor treating fields to the subject, at least one of the treatment locations for further delivering tumor treating fields to the subject.
  2. 2. The method of claim 1, wherein the plurality of treatment locations are generated by a computer-implemented method based on at least one medical image of the subject.
  3. 3. The method of claim 1, wherein the plurality of treatment locations are selected from a database of treatment locations based on attributes of the subject.
  4. 4. The method of claim 1, wherein, for each treatment location, the tumor treating fields are delivered for approximately 30 minutes to approximately 6 hours.
  5. 5. The method of claim 1, wherein, for each treatment location, the tumor treating fields are delivered until at least one measured electrical parameter related to delivering tumor treating fields to the subject reaches a steady state for a predetermined time period, wherein the at least one measured electrical parameter is current or voltage.
  6. 6. The method of claim 5, wherein the steady state for the measured electrical parameter is reached when the measured electrical parameter is constant without substantial ringing for the predetermined time period.
  7. 7. The method of claim 5, wherein the steady state for the measured electrical parameter is reached when the measured electrical parameter is within approximately 0.2% to approximately 2% of a constant value for the predetermined time period.
  8. 8. The method of claim 5, wherein the steady state for the measured electrical parameter is reached when at least one of: a measured current is within approximately 0.02 amps to approximately 0.2 amps of a constant value for the predetermined time period, or a measured voltage is within approximately 0.02 volts to approximately 0.2 volts of a constant value for the predetermined time period.
  9. 9. The method of claim 1, wherein, for each treatment location, the data recorded from delivering tumor treating fields to the subject comprises measured voltages and measured currents from delivering tumor treating fields to the subject.
  10. 10. The method of claim 1, wherein, for each treatment location, the data recorded from delivering tumor treating fields to the subject comprises subjective data obtained from the subject regarding delivering tumor treating fields to the subject.
  11. 11. The method of claim 1, wherein, for each treatment location, the data recorded from delivering tumor treating fields to the subject comprises subjective data regarding states of the transducers after the transducers are removed from the subject.
  12. 12. The method of claim 1, further comprising processing the data recorded for each treatment location to obtain processed data, wherein selecting at least one of the treatment locations for further delivering tumor treating fields to the subject is based on the processed data.
  13. 13. The method of claim 1, wherein further delivering tumor treating fields to the subject is for a time period to receive a full dosage of tumor treating fields.
  14. 14. A method for treatment planning for delivering tumor treating fields to a subject, the method comprising: for each of a plurality of treatment locations for delivering tumor treating fields to a subject, each treatment location comprising a plurality of transducer locations for delivering tumor treating fields to the subject; locating a plurality of transducers on the subject, wherein each transducer is located on the subject according to a respective transducer location for the treatment location; delivering tumor treating fields to the subject using the transducers; and recording data from delivering tumor treating fields to the subject; and selecting, based on the data recorded from delivering tumor treating fields to the subject, at least one of the treatment locations for further delivering tumor treating fields to the subject.
  15. 15. An apparatus for treatment planning for delivering tumor treating fields to a subject, the method comprising: a voltage generator to generate voltages for delivering tumor treating fields to a subject via transducers located on the subject; one or more sensors to measure at least one parameter associated with delivering tumor treating fields to the subject; an input device to receive feedback from a subject regarding delivering tumor treating fields to the subject; and a controller comprising: one or more processors; and memory accessible by the one or more processors, the memory storing instructions that when executed by the one or more processors, cause the controller to instruct the voltage generator to generate signals for tumor treating fields until current measured from delivering tumor treating fields to the subject reaches a steady state for a predetermined time period, wherein the memory stores a log file to record information from the one or more sensors and the input device.

Description

TREATMENT PLANNING FOR DELIVERING TUMOR TREATING FIELDS USING PATIENT DATA CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority to U.S. Patent Application No. 18/746,363, filed June 18, 2024, and U.S. Provisional Application No. 63/524,534, filed June 30, 2023, which are incorporated herein by reference in their entirety. BACKGROUND [0002] Tumor treating fields (TTFields) are low intensity alternating electric fields within the intermediate frequency range (for example, 50 kHz to 1 MHz), which may be used to treat tumors as described in U.S. Patent No. 7,565,205. TTFields are induced non- invasively into the region of interest by transducers placed on the patient’ s body and applying AC voltages between the transducers. Conventionally, transducers used to generate TTFields include a plurality of electrode elements comprising ceramic disks. One side of each ceramic disk is positioned against the patient’s skin, and the other side of each disc has a conductive backing. Electrical signals are applied to this conductive backing, and these signals are capacitively coupled into the patient’s body through the ceramic discs. Conventional transducer designs include arrays of ceramic disks attached to a subject’s body via a conductive skin-contact layer such as a hydrogel. AC voltage is applied between a pair of transducers for an interval of time to generate an electric field with field lines generally running in the front-back direction. Then, AC voltage is applied at the same frequency between at least another pair of transducers for another interval of time to generate an electric field with field lines generally running in the right-left direction. The system then repeats this two-step sequence throughout the treatment. BRIEF DESCRIPTION OF THE DRAWINGS [0003] FIG. 1 depicts an example method for treatment planning for delivering TTFields to a subject. [0004] FIG. 2 depicts an example system for delivering TTFields to a subject’s body. [0005] FIGS. 3 A and 3B depict schematic views of exemplary designs of a transducer for applying alternating electric fields. [0006] FIG. 4 depicts an example placement of transducers on a subject’s head . [0007] FIG. 5 an example computer apparatus. DESCRIPTION OF EMBODIMENTS [0008] This application describes exemplary techniques for treatment planning for delivering TTFields to a subject by assessing different possible treatment locations for delivering TTFields to the subject. [0009] Determining treatment locations for delivering TTFields to a subject can be a very complex process involving large amounts of data and intensive computational requirements. The computational solving of complex algorithms required for determining the treatment locations can take a significant amount of time. For example, determining treatment locations for delivering TTFields to the subject may require obtaining multiple medical images of a subject, processing the medical images to determine the location of a tumor in the subject, assigning conductivities to tissue types of the subject, generating a three-dimensional model of the subject, simulating applying TTFields to the subject for numerous transducer locations on the subject, calculating TTFields dosages for each of the simulated transducer locations, and selecting one or more transducer locations to deliver TTFields to the subject. [0010] The inventors recognized that a need exists for a process that is less expensive, less computationally intensive, and/or less time consuming for treatment planning for delivering TTFields to a subject. [0011] The inventive techniques are particularly integrated into a practical application. Exemplary treatment planning for delivering TTFields is determined based on data received for different possible treatment locations of transducers by actually delivering TTFields to the different possible treatment locations. The different possible treatment locations to be used for testing can be obtained based on information obtained regarding the subject. Data is received from using different treatment locations of transducers on the subject to determine which treatment location(s) would be ideal for the subject. For each treatment location, TTFields are delivered until at least steady state is reached for the TTFields. The data is received from sensors and the subject regarding each treatment location. The data is processed and presented for selecting one or more treatment location(s) for further application of TTFields to the subject. With the inventive techniques described herein, more transducer locations may be evaluated much quicker than with conventional techniques. [0012] FIG. 1 depicts an example method 100 for selecting one or more treatment locations for delivering TTFields to a subject. Aspects of the method 100 may be implemented by a computer, the computer including one or more processors and memory accessible by the one or more processors, the memory storing instructions th