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EP-4736648-A1 - COMPOSITION, PEST CONTROL PREPARATION, AND PEST CONTROL METHOD

EP4736648A1EP 4736648 A1EP4736648 A1EP 4736648A1EP-4736648-A1

Abstract

The present invention aims to provide a composition that is useful in the production of a pest control formulation, and that contains Veratridine and Cevadine. The present invention specifically provides a composition that contains Veratridine, Cevadine, and one or more glycol monoalkyl ether-based solvents having 3 to 8 carbon atoms; a pest control formulation containing the composition; and a pest control method using the pest control formulation.

Inventors

  • SONOBE, Fuhito

Assignees

  • Sumitomo Chemical Company, Limited

Dates

Publication Date
20260506
Application Date
20240628

Claims (15)

  1. A composition comprising Veratridine, Cevadine, and one or more glycol monoalkyl ether-based solvents having 3 to 8 carbon atoms.
  2. The composition according to [1], wherein the glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms is one or more compounds selected from ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monoisopropyl ether, ethylene glycol mono t-butyl ether, 3-methoxybutanol (butylene glycol-3-methoxy ether), 3-methyl-3-methoxy-1-butanol (isobutylene glycol-3-methoxy ether), and propylene glycol monomethyl ether.
  3. The composition according to claim 1 or 2, wherein the ratio of (the total parts by weight of Veratridine and Cevadine) to (the total parts by weight of the glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms) is 1:1 to 1:1000.
  4. The composition according to any one of claims 1 to 3, wherein the total weight of Veratridine and Cevadine is 5% by weight or less relative to the total weight of the composition.
  5. The composition according to any one of claims 1 to 4, wherein the total weight of Veratridine and Cevadine is 0.05% by weight or more and 5% by weight or less relative to the total weight of the composition.
  6. The composition according to any one of claims 1 to 5, further comprising a glycol-based solvent having 3 to 6 carbon atoms selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butanediol, and 3-methyl-1,3-butanediol.
  7. The composition according to claim 6, wherein the glycol-based solvent having 3 to 6 carbon atoms is propylene glycol.
  8. The composition according to any one of claims 1 to 7, wherein Veratridine and Cevadine are contained in a Sabadilla seed extract.
  9. The composition according to claim 8, wherein the Sabadilla seed extract is a propylene glycol solution.
  10. The composition according to claim 9, wherein the total weight of Veratridine and Cevadine in the propylene glycol solution which is the Sabadilla seed extract is 0.1% to 50% by weight.
  11. A pest control formulation comprising the composition according to any one of claims 1 to 10.
  12. The pest control formulation according to claim 11, wherein the pest is a pest arthropod.
  13. The pest control formulation according to claim 12, wherein the pest arthropod is Diptera or Blattodea.
  14. A pest control method comprising a step of applying the pest control formulation according to any one of claims 11 to 13 to a pest, its habitat, or an area where it is expected to appear.
  15. The composition according to any one of claims 1 to 10, further comprising one or more components selected from Group (a): Group (a) consists of acetylcholinesterase inhibitors, GABA-gated chloride ion channel blockers, sodium channel modulators, nicotinic acetylcholine receptor competitive modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride ion channel allosteric modulators, juvenile hormone mimics, multisite inhibitors, chordotonal organ TRPV channel modulators, mites growth inhibitors, microbial disruptors of insect midgut membranes, mitochondrial ATP synthase inhibitors, uncouplers of oxidative phosphorylation, nicotinic acetylcholine receptor channel blockers, chitin synthesis inhibitors, molting inhibitors, ecdysone receptor agonists, octopamine receptor agonists, inhibitors of mitochondrial electron transport chain complexes I, II, III, and IV, voltage-dependent sodium channel blockers, acetyl-CoA carboxylase inhibitors, ryanodine receptor modulators, chordotonal organ modulators, microbial insecticides, acaricidal active ingredients, and nematicidal active ingredients.

Description

[Technical Field] This application claims priority to and the benefit of Japanese Patent Application No. 2023-108107 filed on June 30, 2023 according to the Paris Convention, the entire contents of which are incorporated herein by reference. The present invention relates to a composition containing insecticidal active ingredients contained in Sabadilla seed extracts, specifically Veratridine and Cevadine, and a glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms; a pest control composition containing the composition; and a pest control method using the composition. [Background Art] Plants of Schoenocaulon spp. are generally referred to as Sabadilla, and a naturally occurring insecticide has been obtained from various tissues of Sabadilla. In particular, the species with the longest history among them is Schoenocaulon officinale. Veratridine and Cevadine are known as alkaloid active ingredients contained in Sabadilla seeds, and these alkaloids are known to have insecticidal activity. As an extract of Sabadilla seeds obtained by extracting these alkaloid active ingredients from the Sabadilla seeds, a glycol-based solvent (for example, propylene glycol) extract of Sabadilla seeds by McLaughlin Gormley King Company (MGK) has been reported (see Patent Literatures 1 and 2). [Citation List] [Patent Literature] [Patent Literature 1] WO 2017/070451 A1[Patent Literature 2] WO 2019/133423 A1 [Summary of the Invention] [Problems to be Solved by the Invention] To use these alkaloid components or the alkaloid components contained in Sabadilla seed extracts as active ingredients in formulations, especially in aerosols, it is necessary to dissolve these alkaloid components in a solvent. In particular, there is a demand for novel insecticides that are different from conventional insecticides using pyrethroid-based ingredients (for example, synthetic pyrethroids) as active ingredients. [Means for Solving the Problems] The present inventor conducted extensive research to solve the above problem and found that Veratridine and Cevadine dissolve in specific glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms, thus completing the present invention. That is, the present invention relates to a composition characterized by containing Veratridine, Cevadine, a glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms; a pest control composition characterized by containing the composition; and a pest control method characterized by using the composition. Accordingly, embodiments of the present invention includes the following. [1] A composition containing Veratridine, Cevadine, and one or more glycol monoalkyl ether-based solvents having 3 to 8 carbon atoms.[2] The composition according to [1], wherein the glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms is one or more compounds selected from ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monoisopropyl ether, ethylene glycol mono t-butyl ether, 3-methoxybutanol (butylene glycol-3-methoxy ether), 3-methyl-3-methoxy-1-butanol (isobutylene glycol-3-methoxy ether), and propylene glycol monomethyl ether.[3] The composition according to [1] or [2], wherein the ratio of (the total parts by weight of Veratridine and Cevadine) to (the total parts by weight of the glycol monoalkyl ether-based solvent having 3 to 8 carbon atoms) is 1:1 to 1:1000.[4] The composition according to any one of [1] to [3], wherein the total weight of Veratridine and Cevadine is 5% by weight or less relative to the total weight of the composition.[5] The composition according to any one of [1] to [4], wherein the total weight of Veratridine and Cevadine is 0.05% by weight or more and 5% by weight or less relative to the total weight of the composition.[6] The composition according to any one of [1] to [5], further containing a glycol-based solvent having 3 to 6 carbon atoms selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butanediol, and 3-methyl-1,3-butanediol.[7] The composition according to [6], wherein the glycol-based solvent having 3 to 6 carbon atoms is propylene glycol.[8] The composition according to any one of [1] to [7], wherein Veratridine and Cevadine are contained in a Sabadilla seed extract.[9] The composition according to [8], wherein the Sabadilla seed extract is a propylene glycol solution.[10] The composition according to [9], wherein the total weight of Veratridine and Cevadine in the propylene glycol solution which is the Sabadilla seed extract is 0.1% to 50% by weight.[11] A pest control formulation containing the composition according to any one of [1] to [10].[12] The pest control formulation according to [11], wherein the pest is a pest arthropod.[13] The pest control formulation according to [12], wherein the pest arthropod is Diptera or Blattodea.[14] A pest control method including a step of applying the pest control formulation according to any one of [11] to[13] to a pest, its hab