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EP-4736849-A1 - COMPOSITION FOR ACTIVATING MITOCHONDRIA

EP4736849A1EP 4736849 A1EP4736849 A1EP 4736849A1EP-4736849-A1

Abstract

Provided is a method that can activate metabolism. Specifically provided is a composition for activating mitochondria, comprising a specific component.

Inventors

  • REHAB, Alshargabi
  • ISHIKADO, ATSUSHI
  • MATSUMOTO, MOTONOBU

Assignees

  • SUNSTAR INC.

Dates

Publication Date
20260506
Application Date
20240527

Claims (15)

  1. A compound for use in improving periodontal disease, the compound being at least one compound selected from the group consisting of: panthenol, pantothenic acid or a salt thereof, protamine or a salt thereof, and methionine or a salt thereof.
  2. The compound for use in improving periodontal disease according to claim 1, wherein the compound comprises: (A) pantothenic acid or a salt thereof, and (B) at least one selected from the group consisting of methionine or a salt thereof, protamine or a salt thereof, ceramide, and rice bran.
  3. The compound for use in improving periodontal disease according to claim 1, wherein the compound comprises: (C) panthenol, and (D) at least one selected from the group consisting of cinnamon oil, and glutamic acid or a salt thereof.
  4. The compound for use in improving periodontal disease according to any one of claims 1 to 3, wherein the periodontal disease is periodontal disease in a diabetic patient.
  5. A compound for use in activating mitochondria, the compound being at least one compound selected from the group consisting of: panthenol, pantothenic acid or a salt thereof, protamine or a salt thereof, and methionine or a salt thereof.
  6. The compound for use in activating mitochondria according to claim 5, wherein the compound comprises: (A) pantothenic acid or a salt thereof, and (B) at least one selected from the group consisting of methionine or a salt thereof, protamine or a salt thereof, ceramide, and rice bran.
  7. The compound for use in activating mitochondria according to claim 5, wherein the compound comprises: (C) panthenol, and (D) at least one selected from the group consisting of cinnamon oil, and glutamic acid or a salt thereof.
  8. The compound for use in activating mitochondria according to any one of claims 5 to 7, wherein the mitochondria are mitochondria in periodontal ligament cells.
  9. A compound for use in improving a symptom caused by diabetes, prediabetes, or an age-related metabolic disorder, the compound being at least one compound selected from the group consisting of: panthenol, pantothenic acid or a salt thereof, protamine or a salt thereof, and methionine or a salt thereof.
  10. The compound for use in improving a symptom caused by diabetes, prediabetes, or an age-related metabolic disorder according to claim 9, wherein the compound comprises: (A) pantothenic acid or a salt thereof, and (B) at least one selected from the group consisting of methionine or a salt thereof, protamine or a salt thereof, ceramide, and rice bran.
  11. The compound for use in improving a symptom caused by diabetes, prediabetes, or an age-related metabolic disorder according to claim 9, wherein the compound comprises: (C) panthenol, and (D) at least one selected from the group consisting of cinnamon oil, and glutamic acid or a salt thereof.
  12. The compound for use in improving a symptom caused by diabetes, prediabetes, or an age-related metabolic disorder according to any one of claims 9 to 11, wherein the symptom caused by diabetes, prediabetes, or an age-related metabolic disorder is obesity, renal dysfunction, retinopathy, neuropathy, cardiovascular disease, brain dysfunction, dementia, frailty, muscle weakness, or osteoporosis.
  13. An oral composition or composition for oral cavity, comprising the compound according to any one of claims 1 to 12.
  14. A food composition, comprising the compound according to any one of claims 1 to 12.
  15. The composition for oral cavity according to claim 13, which is an ointment, a paste, a dermatological paste, a gel, a liquid, a spray, a mouthwash, a liquid dentifrice, a toothpaste, or a gum.

Description

Technical Field The present disclosure relates to a composition for activating mitochondria and the like. Background Art Various factors (e.g., high-glucose loads) are known to increase oxidative stress within cells, causing metabolic abnormalities. In particular, diabetic patients and those at risk of developing diabetes are considered to receive high-glucose loads, which lead to metabolic abnormalities, triggering various symptoms. These symptoms may also include symptoms in the oral cavity. For example, it has been reported that the metabolic function of periodontal tissues is impaired in diabetic conditions, and that activating the metabolic function of the gingiva of diabetic rats inhibits alveolar bone resorption. Citation List Non-patent Literature NPL 1: J Clin Periodontol 2017; 44: 463-471. IADR/PER General Session 2018; Presentation ID 1622 Summary of Invention Technical Problem The present inventors searched for a means capable of activating metabolism. Solution to Problem For example, even if oxidative stress within cells increases, metabolism activation can be expected to cause fewer metabolic abnormalities. For this reason, a means capable of activating metabolism is considered to be useful. The present inventors focused on the function of mitochondria, which play a significant role in intracellular metabolism, particularly the ability to produce ATP and/or consume oxygen in cells, and searched for materials that can enhance ATP production and the oxygen consumption rate, or improve reduction in ATP production and reduction in the oxygen consumption rate. The present disclosure includes, for example, the subject matter set forth in the following items. Item 1-1. A composition for activating mitochondria, comprising at least one selected from the group consisting of components listed in the following table. Table 1aChamomile extractCistanche extractOlive leaf extractInositolEucommia extractArnica flower extractReduced palatinoseHoneysuckle leaf extractPeony root extractPanax ginseng root extractGinger extractPlacenta extractLamium album extractMelilotus extractIsoleucineWillow extractWild grape extractValerian root extractFennel extractDevil's claw extractHypericum extractCholecalciferolGlycyrrhizic acid or a salt thereofSenega extractAllantoinRice bran extractFermented black garlic extractAlaninePurple brown rice extractProtamine or a salt thereofWild thyme extractCinnamaldehydeTurmeric rhizome extractPanax notoginseng extractRed ginger extractParamylonOat extractPlantago herb extractCyclodextrinHouttuynia cordata leaf extractArginineGoji berry extractCeramideMethionineRosemary leaf extractEchinacea extractYacon leaf extractPantothenic acidPanthenolSoybean extract Item 1-2. The composition according to Item 1-1, wherein the mitochondria are mitochondria in periodontal ligament cells. Item 1-3. The composition according to Item 1-1 or 1-2, wherein mitochondrial activation is an increase in oxygen consumption in mitochondria. Item 2-1. A composition for activating mitochondria, comprising at least one selected from the group consisting of pantothenic acid or a salt thereof, protamine or a salt thereof, and methionine or a salt thereof. Item 2-2. The composition according to Item 2-1, wherein the mitochondria are mitochondria in periodontal ligament cells. Item 2-3. The composition according to Item 2-1 or 2-2, wherein mitochondrial activation is at least one selected from the group consisting of an increase in oxygen consumption in mitochondria, an improvement in ATP production capacity in mitochondria, and an increase in mitochondria. Item 2-4. The composition according to any one of Items 2-1 to 2-3, which is used to improve periodontal disease in a diabetic patient. Item 2-5. A composition for improving a symptom caused by diabetes, prediabetes, or an age-related metabolic disorder, the composition comprising at least one selected from the group consisting of pantothenic acid or a salt thereof, protamine or a salt thereof, and methionine or a salt thereof. Item 2-6. The composition according to Item 2-5, wherein the symptom caused by diabetes, prediabetes, or an age-related metabolic disorder is obesity, renal dysfunction, retinopathy, neuropathy, cardiovascular disease, brain dysfunction, dementia, frailty, muscle weakness, or osteoporosis. Item 2-7. The composition according to any one of Items 2-1 to 2-6, which is an oral composition or a composition for oral cavity. Item 2-8. The composition according to any one of Items 2-1 to 2-6, which is a food composition. Item 2-9. The composition for oral cavity according to Item 2-7, which is an ointment, a paste, a dermatological paste, a gel, a liquid, a spray, a mouthwash, a liquid dentifrice, a toothpaste, or a gum. Item 3-1. A composition for activating mitochondria, comprising: (A) pantothenic acid or a salt thereof, and(B) at least one selected from the group consisting of methionine or a salt thereof, protamine or a salt thereof, ceramide,