EP-4736850-A1 - USE OF A COMBINATION OF GLYCINE, L-PROLINE, L-LYSINE, L-ASPARTIC ACID, CITRIC ACID AND VITAMIN C, IN THE PREVENTION OF HEALTH AND PERFORMANCE CONDITIONS IN PHYSICAL EXERCISES IN A SUBJECT

Abstract

The present invention is a method to improve physical-sports performance, reduce fatigue, combat physical-sports aging, and to cure and prevent physical injuries, based on an effective dose of glycine, L -proline, L -lysine, L -aspartic acid (or L -aspartate, citric acid, or citrate), and vitamin C. The method is based on the limitations and subsequent conditions of the metabolism in three aspects: (1) the synthesis of ATP in mitochondria, dependent on the Krebs cycle; (2) the synthesis of proteins of the passive mechanical system (collagen and elastin); (3) the mechanism of muscle contraction in actin-myosin interaction cross-bridge cycles. while ensuring that the diet must contain a sufficient amount of protein.

Inventors

• MELENDEZ HEVIA, ENRIQUE
• Matos Expósito, Gustavo Adolfo

Assignees

• Melendez Hevia, Enrique
• Matos Expósito, Gustavo Adolfo

Dates

Publication Date

20260506

Application Date

20241031

Claims (13)

1. Use of a combination of glycine, L -proline, L -lysine, an acid selected from L -aspartic acid and citric acid or a combination thereof, and vitamin C, or a pharmaceutically acceptable salt thereof, in the prevention of health and performance conditions in physical exercises in a subject.
2. The use according to claim 1, wherein said health condition is selected from the group consisting of physical fitness, physical fatigue, and physical aging.
3. The use according to claims 1 or 2, wherein said salt of L -aspartic acid or citric acid is a potassium salt, or a magnesium salt.
4. The use according to any one of claims 1 to 3, where said combination comprises a dosage of 5.0-20.0 g/day of glycine, 2.5-10 g/day of L-proline, 1.25-5.0 g/day of L -lysine, 6.0-24.0 g/day of L -aspartic acid or 6.0-24.0 g/day of citric acid, and 1.0-2.0 g/day vitamin C, or of a pharmaceutically acceptable salt thereof.
5. The use according to any one of claims 1 to 4, wherein said subject is a mammal.
6. The use according to claim 5, wherein said mammal is human.
7. A combination of glycine, L -proline, L -lysine, an acid selected from L -aspartic acid and citric acid or a combination thereof, and vitamin C, or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of physical injuries in a subject.
8. The combination for use according to claim 7, wherein said subject is a mammal.
9. The combination for use according to claim 8, wherein said mammal is human.
10. A nutraceutical composition comprising the combination as defined in claim 4.
11. A pharmaceutical composition comprising the combination as defined in claim 4, and a pharmaceutically acceptable excipient.
12. A pharmaceutical composition according to claim 11, wherein said composition is a topical composition in form of cream, a gel, or a solution.
13. The pharmaceutical or nutraceutical composition according to claims 10 or 11, wherein said compositions are in the form of a crystalline powder.

Description

FIELD OF INVENTION The present invention is of the health filed and relates to novel therapeutic and non-therapeutic uses for glycine, L-proline, L-lysine, vitamin C, L-aspartic acid (or citric acid, or their K+-Mg2+salts), and vitamin C. BACKGROUND We must begin by pointing out that the objective of what we propose here is not simply an increase in physical fitness, but rather to achieve a comprehensive result on the mechanical and energetic system of the muscle, which includes the improvement of physical fitness, the repair and prevention of injuries, and the combat or delay of sports aging. In turn, we consider physical fitness - and its improvement - as a complex function that includes five variables: strength (s), endurance (e), velocity (v), achievements-effectiveness (a), and minimizing the discomfort (d), which is a sign of injury. Therefore, the background where any of these aspects have been studied separately, omitting others, is not significant for our proposal, since it is useless, for example, to increase resistance if this leads to a loss of strength, speed, or aim, just as it is useless to increase resistance if it leads to long-lasting fatigue that leaves the athlete useless for several days or weeks. Energy machinery - The Krebs cycle The Krebs cycle, shown in Figure 1, is the central pathway of metabolism, as all its intermediaries and substrates interact with other routes, and all the routes are more or less closely related to their substrates or intermediaries. Its main quantitative function is the aerobic production of ATP, being the main source of the reduction equivalents (NADH and FADH2) that enter the respiratory chain to produce ATP. Anaplerosis - Cataplerosis The external supply of oxaloacetate or any intermediate of the cycle is called anaplerosis (filling priming or feeding) and the opposite cataplerosis (drainage); these two types of processes participate together in the regulation of the activity of the Krebs cycle. Figure 1 shows the intermediates that are sites of anaplerosis and cataplerosis. Anaplerosis of the Krebs cycle is, therefore, an ideal way of increasing its activity, rather than increasing the concentration of the substrate AcCoA, or any of its sources. Anaplerosis and cataplerosis are opposite processes that can work in coordination to regulate the activity of the Krebs cycle. However, there are cataplerotic processes whose function is not this regulation but are imposed by the need to synthesize specific products. For the cases at hand, the synthesis of porphyrins from succinyl-CoA, and the hydroxylations of proline and lysine residues in the synthesis of collagen from a-ketoglutarate are highlighted. Injuries There is a mutual interaction between these two concepts: lack of fitness leads to injuries, and injuries are an important cause of decreased fitness; here we are not referring to traumatic injuries, whose loss of fitness is obvious, but to injuries not noticed as such, which we will discuss below. It should be noted that, apart from the health and well-being of the individual, all of this has a great economic interest, especially in professional athletes, and in jobs that are highly dependent on physical fitness. such as acrobats, film extras, police officers, firemen, etc. Medical treatments for traumatic injuries have improved greatly in recent years, especially in surgery and physiotherapy, but they seem to have reached a point where no further progress is expected, with recovery times in many cases taking months or years. Apart from personal injury, injuries in this area mean a huge financial loss for the club (and in many cases for the athlete), which can be the biggest expense in the budget. On the other hand, there is little to say about prevention, where very little progress has been made, apart from avoiding falls and collisions, which is impossible in high-level contact sports. This invention is not just a matter of curing injuries, but of avoiding them. Good fitness should mean not only performing well but avoiding injuries. We distinguish three types of injuries: traumatic injuries, and injuries caused by over-exertion that leads to tiredness and fatigue. 2 (a) Traumatic injuries When talking about physical injuries, we always think of traumatic injuries because the injury is identified with an accident, looking for an external cause. Traumatic injuries are frequent. They may be accidental, but in sportsmen - especially in contact sports, such as football, American football, rugby, and combat sports - injuries are extremely frequent because players are continually exposed to them; in amateur sportsmen (skiing, paddle tennis, and Canarian wrestling, among others) many injuries occur because they are not well prepared physically, or who are forced to overexert themselves due to a lack of good technical preparation. They are also frequent in sports that do not involve contact, and in non-sportsmen, generally, due to falls, or bad movements. A m