Search

EP-4736907-A1 - A DRUG DELIVERY SYSTEM

EP4736907A1EP 4736907 A1EP4736907 A1EP 4736907A1EP-4736907-A1

Abstract

The drug delivery system (1), comprises: - a first bag (21) containing a drug in liquid form; - a second bag (22) configured to be inflated to compress the first bag for expelling the drug; - a gas supply system (30) comprising a gas container (31) and a gas connector (40) for fluidly connecting the gas container to the second bag inlet (25), to inflate the second bag; - a dispensing system (50) comprising an injection device (51) and a liquid connector (55) for fluidly connecting the first bag outlet (23) to the injection device inlet (52), wherein: - in the inactive state of the dispensing system, the liquid connector blocks the fluid communication and the injection device is in a retracted position, - in the active state of the dispensing system, the liquid connector fluidly connects the first bag outlet and the injection device inlet, and the injection device is in an extended position for penetrating an injection site; - an activation system (100) comprising a trigger (101) which can be moved from a rest position to an activated position, thereby: - causing the gas supply system to go from its inactive state to its active state, thus causing the second bag to inflate and to compress the first bag; - and causing the dispensing system to go from its inactive state to its active state, thus allowing the drug contained in the first bag to be delivered to the injection site.

Inventors

  • DELOBELLE, Vincent
  • KALLEL, Hanen

Assignees

  • Becton Dickinson France

Dates

Publication Date
20260506
Application Date
20241104

Claims (15)

  1. A drug delivery system (1), comprising: - a first bag (21) configured to contain a drug in liquid form, the first bag (21) having an outlet (23); - a second bag (22) without fluid communication with said first bag (21), the second bag (22) having an inlet (25), the second bag (22) being arranged adjacent the first bag (21) and configured to be filled with a gas through its inlet (25) so as to inflate and, as a result, to compress the first bag (21) in order to expel the drug from the first bag (21) through the first bag outlet (23); - a gas supply system (30) which can be in an inactive state or in an active state, and which comprises: - a gas container (31); - a gas connector (40) configured to fluidly connect the gas container (31) to the second bag inlet (25) in the active state of the gas supply system (30), to allow inflating the second bag (22); - a dispensing system (50) which can be in an inactive state or in an active state, and which comprises an injection device (51) having an inlet (52), and a liquid connector (55) configured to fluidly connect the first bag outlet (23) to the injection device inlet (52), wherein: - in the inactive state of the dispensing system (50), the liquid connector (55) is in a blocking state in which it prevents fluid communication between the first bag outlet (23) and the injection device inlet (52), and the injection device (51) is in a retracted position, and - in the active state of the dispensing system (50), the liquid connector (55) is in a connecting state in which it fluidly connects the first bag outlet (23) and the injection device inlet (52), and the injection device (51) is in an extended position in which it can penetrate an injection site; - an activation system (100) comprising a trigger (101) which can be moved from a rest position to an activated position, thereby: - causing the gas supply system (30) to go from its inactive state to its active state, thus causing the second bag (22) to inflate and to compress the first bag (21); - and causing the dispensing system (50) to go from its inactive state to its active state, thus allowing the drug contained in the first bag (21) to flow to the injection device inlet (52) and ultimately to be delivered to the injection site.
  2. The drug delivery system according to claim 1, characterized in that the activation system (100) comprises a gas actuator (110) configured to be moved from a rest position to an operational position by the trigger (101) when the trigger (101) is moved from its rest position to its activated position, so that the gas actuator (110) places the gas supply system (30) in its active state.
  3. The drug delivery system according to claim 2, characterized in that the gas actuator (110) comprises holding means (113, 114) for holding said gas actuator (110) in the rest position and/or holding means (113, 114) for holding said gas actuator (110) in the operational position.
  4. The drug delivery system according to any one of claims 1 to 3, characterized in that the activation system (100) comprises a liquid actuator (120) configured to be moved from a rest position to an operational position as a result of the trigger (101) moving from its rest position to its activated position, so that the activation system (100) places the dispensing system (50) in its active state.
  5. The drug delivery system according to claim 4, characterized in that the liquid actuator (120) is configured to be moved from its rest position to its operational position: - by the trigger (101) when the trigger (101) is moved from its rest position to its activated position; - or by an intermediate member (150) which goes to an active state as a result of the movement of the trigger (101).
  6. The drug delivery system according to claim 4 or 5, characterized in that the liquid actuator (120) is configured to cause: - a flow shutter of the liquid connector (55) to move from a closed to an open position, to allow fluid communication between the first bag outlet (23) and the injection device inlet (52); - and/or a retaining device of the injection device (51) to be released, to allow the injection device (51) to go from its retracted position to its extended position; when the liquid actuator (120) is moved from its rest position to its operational position.
  7. The drug delivery system according to any one of claims 4 to 6, characterized in that the liquid actuator (120) comprises holding means (127) for holding said liquid actuator (120) in the operational position.
  8. The drug delivery system according to any one of claims 1 to 7, characterized in that it comprises holding means (102, 113, 106) for holding the trigger (101) in its rest position, to prevent its unwanted movement towards the activated position and/or to prevent its movement in the opposite direction.
  9. The drug delivery system according to any one of claims 1 to 8, characterized in that the gas connector (40) comprises a port (41) fluidly connected to the second bag inlet (25) and a hollow pin (43) which is in fluid communication with said port (41), and in that the gas container (31) is closed and located at a distance from said hollow pin (43) in the inactive state of the gas supply system (30), said gas container (31) being movable towards the gas connector (40) up to the active state of the gas supply system (30) in which a wall (33) of the gas container (31) is pierced by said hollow pin (43) to allow gas to flow towards the second bag inlet (25).
  10. The drug delivery system according to claim 9, characterized in that it comprises holding means(37, 38) for preventing the gas container (31) to untimely move towards the hollow pin (43) when the gas supply system (30) is in the inactive state.
  11. The drug delivery system according to any one of claims 1 to 10, characterized in that the gas connector (40) comprises a port (41) fluidly connected to the second bag inlet (25) and a hole (44) distinct from the port (41) and in fluid communication with the port (41), said hole (44) being configured to provide a controlled gas leak.
  12. The drug delivery system according to any one of claims 1 to 11, characterized in that the first bag (21) comprises a first sheet (27) and a second sheet (28) that are superimposed and secured to one another at their peripheral edges (26), and in that the second bag (22) comprises a third sheet (29) that is superimposed to the second sheet (28) opposite the first sheet (27), the second sheet (28) and the third sheet (29) being secured to one another at their peripheral edges (26).
  13. The drug delivery system according to claim 12, characterized in that the first sheet (27) and the third sheet (29) are rigid.
  14. The drug delivery system according to any one of claims 1 to 11, characterized in that the first bag (21) and the second bag (22) are initially distinct and are superimposed and secured to one another, for example by gluing or heat sealing.
  15. The drug delivery system according to any one of claims 1 to 14, characterized in that the first bag (21) has a cross-sectional shape that diverges towards its outlet (23).

Description

The invention relates to a drug delivery system. Particularly, but not exclusively, the invention concerns an on-body drug delivery system, which can be temporarily attached to a patient's body during delivery, thereby allowing long delivery times without requiring someone to hold the system in place. Such drug delivery systems can include a dispensing system for injecting the drug, said dispensing system being activated by the action of a user on a trigger of the drug delivery system. This activation can be achieved by means of a mechanical system, which can include an elastic member such as a spring to provide a pushing force for expelling the drug. However, storing the fairly significant amount of energy needed in such elastic members requires space while the drug delivery system needs to remain compact. Alternatively, this activation can be achieved by means of an electromechanical system. This may require the use of a motor having a fairly significant size to generate sufficient thrust to expel the drug. As a result, drug delivery systems tends to be quite cumbersome and heavy. Besides, the use of electronics components, batteries, etc. is not desirable from an environmental point of view. Although conventional drug delivery systems are generally satisfactory, room for improvement remains. The invention concerns a drug delivery system, comprising: a first bag configured to contain a drug in liquid form, the first bag having an outlet;a second bag without fluid communication with said first bag, the second bag having an inlet, the second bag being arranged adjacent the first bag and configured to be filled with a gas through its inlet so as to inflate and, as a result, to compress the first bag in order to expel the drug from the first bag through the first bag outlet;a gas supply system which can be in an inactive state or in an active state, and which comprises: a gas container;a gas connector configured to fluidly connect the gas container to the second bag inlet in the active state of the gas supply system, to allow inflating the second bag;a dispensing system which can be in an inactive state or in an active state, and which comprises an injection device having an inlet, and a liquid connector configured to fluidly connect the first bag outlet to the injection device inlet, wherein: in the inactive state of the dispensing system, the liquid connector is in a blocking state in which it prevents fluid communication between the first bag outlet and the injection device inlet, and the injection device is in a retracted position, andin the active state of the dispensing system, the liquid connector is in a connecting state in which it fluidly connects the first bag outlet and the injection device inlet, and the injection device is in an extended position in which it can penetrate an injection site;an activation system comprising a trigger which can be moved from a rest position to an activated position, thereby: causing the gas supply system to go from its inactive state to its active state, thus causing the second bag to inflate and to compress the first bag;and causing the dispensing system to go from its inactive state to its active state, thus allowing the drug contained in the first bag to flow to the injection device inlet and ultimately to be delivered to the injection site. Owing to the use of a gas container, which is a device capable of storing a high amount of energy in a small volume, the drug delivery system of the invention can be limited in size and weight as compared to conventional systems. It can therefore be designed as either a wearable system that is intended to remain in place over a long delivery period, or as a handheld system. Furthermore, no electronics are required to operate the drug delivery system, which has environmental benefits. Besides, the two-bag arrangement of the invention has several advantages. On the one hand, this allows the constituent material of a given bag to be adapted to the use of that bag. More specifically, the material of the first bag must be compatible with the drug it contains, while the material of the second bag must be able to withstand the deformation caused by the inflation that second bag. There is no need to select a single material with both the required physical / chemical properties, which can prove difficult. On the other hand, the arrangement of the invention does not require to manage dynamic tightness, but only static tightness, which is easier to design. The terms "without fluid communication" mean that no fluid (whether it is a liquid or a gas) can flow from one of the first and second bags towards the other. Besides, a component which "fluidly connects" two elements allows fluid to flow from one of the first and second elements towards the other. The drug delivery system may further comprise a housing. The housing can have one compartment for receiving the first and second bags, and one compartment for receiving the gas supply syste