EP-4739127-A1 - COMPOSITION FOR INCREASING A COGNITIVE SKILL

Abstract

The present invention relates to a chewable composition, preferably a chewing gum-based composition, the composition containing: lecithin; b) oligomeric procyanidines; c) at least one substance from the group consisting of glucosides, ginsenosides and bacosides; and d) preferably a masticatory substance.

Inventors

• NOURANI, Faraz

Assignees

• SFN Holding AG

Dates

Publication Date

20260513

Application Date

20240708

Claims (20)

1. New PCT patent application based on EP 23184320.2 SFN Holding AG Vossius Ref.: AG2774 PCT BS Claims 1. Chewable composition, preferably chewing gum-based composition, wherein the composition contains: a) lecithin; b) oligomeric procyanidins; c) at least one substance from the group consisting of glucosides, ginsenosides and bacosides; and d) preferably a chewing base.
2. 2. Composition according to claim 1, wherein the composition additionally contains a substance from the group of flavonoids.
3. 3. Composition according to claim 1 or 2, wherein the composition contains 500 mg - 1500 mg lecithin.
4. 4. Composition according to one of claims 1 to 3, wherein the glucosides are derived from Rhodiola rosea.
5. 5. Composition according to one of claims 2 to 4, wherein the flavonoids are derived from Ginkgo biloba.
6. 6. Composition according to one of claims 1 to 5, wherein the ginsenosides are derived from Panax ginseng.
7. 7. A composition according to any one of claims 1 to 6, wherein the bacosides are derived from Bacopa monnieri.
8. 8. Composition according to one of claims 1 to 7, wherein the oligomeric procyanidins are derived from grape seed flour.
9. 9. Composition according to one of claims 1 to 8, wherein the composition contains: a) 30 to 100 mg Rhodiola rosea powder; b) optionally 40 to 160 mg Ginkgo biloba powder; c) 50 to 200 mg Panax ginseng powder; d) 100 to 300 mg grape seed flour; and/or e) optionally 50 to 200 mg Bacopa monnieri powder.
10. 10. Composition according to one of claims 1 to 9, wherein the composition additionally comprises poly-unsaturated fatty acids (PUFA).
11. 11. The composition of claim 10, wherein the PUFA are derived from camelina oil.
12. 12. A composition according to any one of claims 1 to 11, wherein the composition additionally comprises xylitol.
13. 13. The composition of claim 12, wherein the composition comprises 100 to 2000 mg of xylitol, preferably 100 to 1000 mg of xylitol, more preferably 100 to 500 mg of xylitol.
14. 14. A composition according to any one of claims 1 to 13, wherein the composition additionally comprises a flavoring agent, wherein the flavoring agent is preferably peppermint oil.
15. 15. The composition of claim 14, wherein the composition comprises 40 mg to 120 mg of peppermint oil, preferably 40 mg to 100 mg of peppermint oil, more preferably 40 mg to 80 mg of peppermint oil.
16. 16. A composition according to any one of claims 1 to 15, wherein the composition additionally comprises a substance which improves the passage through the blood-brain barrier for at least one of the ingredients.
17. 17. The composition of claim 16, wherein the substance comprises nanoliposomes and lipopeptide micelles.
18. 18. A composition according to any one of claims 1 to 17, wherein the composition is a pharmaceutical composition additionally comprising at least one pharmaceutically active substance, preferably a painkiller and/or an anti-inflammatory.
19. 19. A composition according to any one of claims 1 to 18, wherein the composition is formulated as a dosage unit.
20. 20. A composition according to claim 19 for use as a medicament.

Description

New PCT patent application based on EP 23184320.2 SFN Holding AG Vossius Ref.: AG2774 PCT BS Composition for increasing cognitive ability The present invention relates to a chewable composition, preferably a chewing gum-based composition, wherein the composition contains: a) lecithin; b) oligomeric procyanidins; c) at least one substance from the group consisting of glucosides, ginsenosides and bacosides; and d) preferably a chewing mass. A large number of documents, including patent applications, patents and operating instructions from various manufacturers, are cited in the description. The disclosure content of each of these documents, although not considered relevant to the patentability of the present invention, is hereby incorporated into the disclosure content of the application. In particular, all documents referred to in these documents are also incorporated into the disclosure content of the application, to the same extent as if each of these documents had been specifically incorporated by reference into the disclosure content of the present application. The increase in cognitive ability (also called "neuroenhancement") has received a lot of attention in recent years. Studies show that the use of substances to (hopefully) increase mental performance is widespread, particularly in performance-oriented professions and among students. However, study results on the effects of various herbal dietary supplements on mental performance are contradictory. These substances include: Ginkgo biloba, ginseng root (Panax ginseng), rose root (Rhodiola rosea), sunflower lecithin, grape seed flour with oligomeric proanthocyanidins (OPC), Brahmi leaves (Bacopa monnieri) and omega-3 fatty acids. In most studies, the substances mentioned were administered orally and are therefore subject to digestion and a first-pass effect. In contrast, there are preparations for several other substances (e.g. nicotine, nitroglycerin) that are absorbed through the oral mucosa and thus have a faster effect and are not subject to a first-pass effect. In addition, only individual substances were tested, whereas due to the different mechanisms of action of the individual substances, a synergistic effect of certain combinations of individual substances would be possible. Thus, there is still a high demand for substances and, above all, compositions of several individual substances that can increase cognitive abilities. This demand is addressed by the present invention. Accordingly, in a first aspect, the present invention relates to a composition which contains a) lecithin; b) oligomeric procyanidins; and c) at least one substance from the group consisting of glucosides, ginsenosides and bacosides, or at least one substance from the group consisting of glycosides, ginsenosides and bacosides. According to a preferred embodiment, the composition contains a) lecithin; b) oligomeric procyanidins; and c) at least two substances from the group consisting of glucosides, ginsenosides and bacosides. According to a further preferred embodiment, the composition contains a) lecithin; b) oligomeric procyanidins; and c) at least one glucoside in each case, and d) at least one ginsenoside in each case. The ingredients of the composition provide an increase in a cognitive ability (also called “neuroenhancement”) in an individual to whom the composition is administered. Accordingly, the composition can be referred to as or used for “a composition for increasing a cognitive ability (also called “neuroenhancement”) in an individual”. The formulation of the composition is not limited and in principle any formulation is suitable that leads to an increase in a cognitive ability in an individual to whom the composition is administered. The composition is preferably a composition that can be administered orally or nasally. The composition is preferably provided as a dosage unit. For oral administration, a formulation of the composition as a liquid, capsule, tablet (in particular lozenge or chewable tablet), snus, powder, jelly, dragée, wine gum or gummy bears, granules, compressed or pastille, chewing gum, chewing bag and candy (in particular lozenge or chewable candy) is suitable. The composition that can be administered orally, is preferably not swallowed or swallowed later, but should remain in the mouth where the contents and active ingredients of the composition according to the invention are released and can then pass through the oral mucosa into the bloodstream and from there into the brain. This results in rapid absorption of the contents and active ingredients of the composition according to the invention, which pass directly into the blood and then into the brain without passing through the intestinal wall and liver. For this purpose, the composition can be placed, for example, under the tongue (sublingual) or in the cheek or lip pocket (buccal, between the cheek and gums) or - as explained further below - chewed. For buccal administration, for examp