EP-4739205-A1 - TOUCH-BASED BIOMARKER MONITORING SYSTEM

Abstract

Provided herein are methods, devices, and systems that pertain to solid-state sensor and sensor-reading meter for touch-based rapid physiological and chemical sensing.

Inventors

• YIN, LU
• MOON, Jongmin
• CHUNG, Saeromi

Assignees

• Persperion Diagnostics Inc.

Dates

Publication Date

20260513

Application Date

20240703

Claims (20)

1. 1. A system, comprising: a test strip comprising a solid-state electrochemical sensor layer and a conductive layer; and a test strip reading device comprising a slot, configured to receive a first portion of the test strip and to keep a surface of a second portion of the test strip uncovered, wherein the uncovered surface is accessible to contact a portion of skin of a user.
2. 2. The system of claim 1, further comprising a computer processor operably coupled to the test strip reading device configured to use the test strip reading device to determine a property of the skin.
3. 3. The system of claim 1, wherein the test strip reading device comprises a physical data port.
4. 4. The system of claim 3, wherein physical data port is a universal serial bus (USB) port.
5. 5. The system of claim 4, wherein the USB port is configured to permit communication between the test strip reading device and a computing system.
6. 6. The system of claim 4, wherein the USB port is configured to receive power from a computing system when connected to the computing system.
7. 7. The system of claim 1, wherein the test strip reading device comprises a wireless communication module.
8. 8. The system of claim 7, wherein the wireless communication module comprises a Bluetooth® communication module, a Wi-Fi® communication module, a near field communication (NFC) module, a cellular communication module, a radio communication module, an ultra wideband communication module, or any combination thereof.
9. 9. The system of claim 1, wherein the test strip reading device is reusable.
10. 10. The system of claim 1, wherein the test strip is reusable.
11. 11. The system of claim 10, wherein the test strip is reusable for at least about 3 days.
12. 12. The system of claim 11, wherein the test strip is reusable for at least about 7 days.
13. 13. The system of claim 10, wherein the test strip is reusable for at least about 15 uses.
14. 14. The system of claim 1, wherein the test strip is not reusable.
15. 15. The system of claim 1, wherein the test strip reading device is not reusable.
16. 16. The system of claim 1, wherein said test strip reading device is configured to, after testing said skin, permit removal of said test strip.
17. 17. The system of claim 16, wherein, after said removal of said test strip, said test strip reading device is configured to receive an additional test strip.
18. 18. The system of claim 1, wherein the test strip reading device is configured to be affixed to a computing device.
19. 19. The system of claim 18, wherein the computing device is a mobile phone, a watch, a wearable device, or a laptop computer.
20. 20. The system of claim 1, wherein the test strip reading device comprises a microprocessor configured to interface with the test strip to take a measurement from the test strip.

Description

TOUCH-BASED BIOMARKER MONITORING SYSTEM CROSS-REFERENCE [0001] This application claims the benefit of U.S. Provisional Application No. 63/512,248, filed July 6, 2023, which application is incorporated herein by reference. BACKGROUND [0002] Sweat contains a number of small-molecule biomarkers and may be a prospective alternative biofluid to blood and interstitial fluid for non-invasive sensing. However, sweatbased sensing may be limited in accuracy and practicality, because these methods often require an additional step of sweat generation and collection process, has long delay compared to bloodbased sensing, and may be influenced by individual differences and sweat rates. As such, there is a need for accurate, convenient, rapid, and non-invasive biomarker sensing while taking advantage of sweat as an easily accessible sample to measure various biomarkers. SUMMARY [0003] In an aspect, the present disclosure provides a system, comprising: a test strip comprising a solid-state electrochemical sensor layer and a conductive layer; and a test strip reading device comprising a slot, configured to receive a first portion of the test strip and to keep a surface of a second portion of the test strip uncovered, wherein the uncovered surface is accessible to contact a portion of skin of a user. [0004] In some embodiments, the system further comprises a computer processor operably coupled to the test strip reading device configured to use the test strip reading device to determine a property of the skin. In some embodiments, the test strip reading device comprises a physical data port. In some embodiments, physical data port is a universal serial bus (USB) port. In some embodiments, the USB port is configured to permit communication between the test strip reading device and a computing system. In some embodiments, the USB port is configured to receive power from a computing system when connected to the computing system. In some embodiments, the test strip reading device comprises a wireless communication module. In some embodiments, the wireless communication module comprises a Bluetooth® communication module, a Wi-Fi® communication module, a near field communication (NFC) module, a cellular communication module, a radio communication module, an ultra wideband communication module, or any combination thereof. In some embodiments, the test strip reading device is reusable. In some embodiments, the test strip is reusable. In some embodiments, the test strip is reusable for at least about 3 days. In some embodiments, the test strip is reusable for at least about 7 days. In some embodiments, the test strip is reusable for at least about 15 uses. In some embodiments, the test strip is not reusable. In some embodiments, the test strip reading device is not reusable. In some embodiments, said test strip reading device is configured to, after testing said skin, permit removal of said test strip. In some embodiments, after said removal of said test strip, said test strip reading device is configured to receive an additional test strip. In some embodiments, the test strip reading device is configured to be affixed to a computing device. In some embodiments, the computing device is a mobile phone, a watch, a wearable device, or a laptop computer. In some embodiments, the test strip reading device comprises a microprocessor configured to interface with the test strip to take a measurement from the test strip. In some embodiments, the system further comprises a lid positioned to protect the uncovered surface of the test strip. In some embodiments, the lid is slidable with respect to the test strip reading device. In some embodiments, the lid is attached to the test strip reading device using a hinge. In some embodiments, the lid comprises one or more sensors configured to determine an open or closed state of said lid. In some embodiments, the test strip reading device has a volume of at most about 4 cubic centimeters (cm3). In some embodiments, the test strip reading device is configured to guide a finger of said user to said test strip. In some embodiments, the system further comprises a display in the test strip reading device. In some embodiments, the system further comprises one or more physical buttons. In some embodiments, the test strip reading device comprises one or more sensors. In some embodiments, said one or more sensors are configured to acquire one or more signals comprising a temperature of the user, a temperature of the test strip reading device, a moisture level of the user, a humidity, a sweat gland density of the user, a sweat rate of the user, a transdermal water loss rate of the user, pressure, a skin hydration level of the user, a heart rate of the user, a blood oxygen level of the user, a blood pressure of the user, a skin conductance of the user, a skin capacitance of the user, a skin resistance of the user, a skin impedance of the user, or any combination thereof. In some embodiments, said test strip read