EP-4739207-A1 - SYSTEM AND METHOD FOR NUCLEAR MAGNETIC RESONANCE MEASUREMENT OF BLOOD ANALYTE LEVELS

Abstract

The nuclear magnetic resonance system can include: a set of magnets, a housing, a set of coils (e.g., receive coil, transmit coil, gradient coil, active shim coil, etc.), and a processing system. The nuclear magnetic resonance method can include: applying a pulse sequence, acquiring a signal, and processing the signal (e.g., to determine blood analyte levels).

Inventors

• NASHMAN, Benjamin
• MCFADYEN, STEPHEN
• GAJDOSIK, Martin

Assignees

• Synex Medical Inc.

Dates

Publication Date

20260513

Application Date

20240808

Claims (1)

1. SYNX-P12-PCT CLAIMS We Claim: 1. A nuclear magnetic resonance (NMR) system, comprising: • a set of magnets producing a magnetic field over a region of interest within a bore configured to receive a finger of a user; • a transmitter; • a receiver comprising a surface coil, wherein a central axis of the surface coil intersects with a pulp of the finger; and • a processing system configured to: • using the transmitter, transmit an electromagnetic pulse sequence; • using the receiver, sample a receive signal; and • determine a blood analyte concentration in the finger based on the receive signal. 2. The NMR system of Claim 1, further comprising a sample interface configured to position a surface of the pulp of the finger within a threshold distance of the surface coil. 3. The NMR system of Claim 2, wherein the threshold distance is less than 5mm. 4. The NMR system of Claim 2, wherein a susceptibility of the sample interface is within 20% of a susceptibility of the finger. 5. The NMR system of Claim 1, wherein the surface coil comprises a loop coil of between 2 and 5 turns. 6. The NMR system of Claim 1, further comprising a set of button shims retained within pockets of a sleeve, wherein the sleeve is positioned within the bore. 7. The NMR system of Claim 1, wherein the region of interest is nonspherical. 8. The NMR system of Claim 7, wherein a length of the region of interest along the central axis of the surface coil is less than a length of the region of interest along an axis perpendicular to the central axis of the surface coil. 9. The NMR system of Claim 1, wherein the set of magnets comprise an array of magnets arranged around the bore, wherein a width of the bore along a first axis is greater than a height of the bore along a second axis, the second axis perpendicular to the first axis; wherein the first axis is parallel to the central axis of the surface coil; wherein the second axis is perpendicular to a longitudinal axis of the bore. SYNX-P12-PCT io. The NMR system of Claim 1, wherein the blood analyte comprises glucose. n. A nuclear magnetic resonance (NMR) system, comprising: • a set of magnets supported by the housing, the magnets producing a magnetic field over a region of interest within a bore configured to receive a finger of a user; • a set of coils comprising: a transmitter, a set of gradient coils, and a receiver; and • a processing system communicatively coupled to the set of coils, the processing system configured to: • using the transmitter, transmit a pulse sequence; • using the set of gradient coils, transmit a sequence of gradient pulses configured to select a target region of the finger; • using the receiver, sample a receive signal; and • determine a blood analyte concentration in the target region of the finger based on the receive signal. 12. The NMR system of Claim 11, wherein a proximal-distal axis of the finger is approximately parallel to and offset from a longitudinal axis of the bore. 13. The NMR system of Claim 11, wherein the target region comprises at least one of the dermis or the hypodermis of a pulp of the finger. 14. The NMR system of Claim 11, wherein the set of gradient coils comprises three gradient coils corresponding to three directions, wherein the target region comprises a voxel, wherein the target region of the finger comprises a voxel, wherein a width of the voxel along a dorsal-palmar axis of the finger is less than a length of the voxel along a radial-ulnar axis of the finger and is less than a length of the voxel along a proximal-distal axis of the finger. 15. The NMR system of Claim 11, wherein a location of the target region is determined based on a calibration signal acquired in a calibration scan. 16. The NMR system of Claim 11, wherein the set coils further comprise a set of shield coils configured to shield the magnetic field generated by the set of gradient coils. SYNX-P12-PCT 17- The NMR system of Claim n, further comprising an active shim coil, wherein the transmitter, the active shim coil, and the set of gradient coils are arranged in a set of layers as nested coils. 18. The NMR system of Claim 17, wherein, for each layer in the set of layers, a width of the layer in a first dimension is greater than a width of the layer in a second dimension. 19. The NMR system of Claim 11, wherein the receiver comprises a surface coil, wherein a gap between the surface coil and a surface of the appendage is less than 10 mm. 20. The NMR system of Claim 11, wherein the blood analyte comprises at least one of glucose or lactate.

Description

SYNX-P12-PCT SYSTEM AND METHOD FOR NUCLEAR MAGNETIC RESONANCE MEASUREMENT OF BLOOD ANALYTE LEVELS CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of US Provisional Application number 63/531,405 filed 08-AUG-2023, US Provisional Application number 63/544,041 filed 13-OCT-2O23, US Provisional Application number 63/544,723 filed 18-OCT-2O23, and US Provisional Application number 63/544,726 filed 18-OCT- 2023, each of which is incorporated in its entirety by this reference. TECHNICAL FIELD [0002] This invention relates generally to the nuclear magnetic resonance field, and more specifically to a new and useful system and method for nuclear magnetic resonance measurement of blood analyte levels in the nuclear magnetic resonance field. BRIEF DESCRIPTION OF THE FIGURES [0003] FIGURE 1 is a schematic representation of a variant of the system. [0004] FIGURE 2 is a schematic representation of a variant of the method. [0005] FIGURES 3A and 3B are cross-sectional views of an example of the system, illustrating a region of interest (ROI) within the bore. [0006] FIGURES 4A and 4B are cross-sectional views of an example of the system, illustrating a target region within the sample (e.g., a finger). [0007] FIGURE 5A is an example of a cross-sectional view of the system, including a set of passive shims (e.g., button shims) and a layered arrangement of a set of coils. [0008] FIGURE 5B is an example of a cross-sectional view of the system, including a set of passive shims (e.g., button shims) and a spiraled arrangement of a set of coils. [0009] FIGURE 6A depicts an example of a measurement scan sequence including a first set of refocusing pulses (e.g., a Carr-Purcell-Meiboom-Gill (CPMG) SYNX-P12-PCT sequence) and a second set of slice-selective refocusing pulses (e.g., a CPMG laser sequence). [0010] FIGURE 6B depicts an example of a measurement scan sequence including a set of refocusing pulses. [0011] FIGURES 7A-7B depict examples of a measurement scan sequence including a perfect echo sequence. [0012] FIGURE 8A is a cross-sectional view of an example of the system. [0013] FIGURE 8B is an exploded view of an example of the system. [0014] FIGURES 8C-8G are cross-sectional views of an example of the system. [0015] FIGURES 8H-8J depict examples of the system. [0016] FIGURES 8K and 8L depict examples of the system without an enclosure. [0017] FIGURE 9A depicts a specific example of a transmit coil wrapped around a coil support. [0018] FIGURE 9B depicts a specific example of a transmit coil not wrapped around a coil support (e.g., prior to wrapping). [0019] FIGURES 10A and 10B depict examples of a receive coil. [0020] FIGURES nA and 11B depict examples of the gradient coil mounted to a coil support. [0021] FIGURE 11C depicts a plot of an example of the gradient coil. [0022] FIGURE 12 depicts an example of a target region on a finger. [0023] FIGURE 13A depicts an example of a sample interface mold. [0024] FIGURE 13B depicts an example of a sample interface. [0025] FIGURE 14 depicts an example of slice selection. [0026] FIGURE 15A depicts an example of full width at half maximum (FWHM) of a water signal across slices. [0027] FIGURE 15B depicts an example of area under the curve for a water signal and a lipid signal across slices. [0028] FIGURES 16A-16C are schematic representations of examples of the system. [0029] FIGURE 17A depicts an example of a free-induction decay sequence. [0030] FIGURE 17B depicts an example of a gradient echo sequence. SYNX-P12-PCT [0031] FIGURE 17C depicts an example of a spin echo sequence. [0032] FIGURE 17D depicts an example of a gradient echo train sequence. [0033] FIGURE 17E depicts an example of a center frequency calibration sequence. [0034] FIGURE 18 depicts an example of a measurement scan sequence. [0035] FIGURES 19A and 19B depict examples of simulations of signals acquired using a spin echo (SE) pulse sequence and a CPMG pulse sequence, the measured signals corresponding to a blood analyte. [0036] FIGURE 20 depicts examples of measured signals acquired using a pulse sequence with loop times between 10ms and 20ms. [0037] FIGURE 21A depicts another example of a measurement scan sequence. [0038] FIGURE 21B depicts an example of a calibration sequence. [0039] FIGURE 21C depicts another example of a measurement scan sequence including a CPMG sequence. [0040] FIGURE 21D depicts an example of a measurement scan sequence including a CPMG sequence with 18 loops. [0041] FIGURE 21E depicts an example of a measurement scan sequence including a localized CPMG sequence. [0042] FIGURE 21F depicts an example of phase cycle steps for a CPMG pulse sequence. [0043] FIGURE 21G depicts an example of a measurement scan sequence including a Periodic Refocusing of J Evolution by Coherence Transfer (PROJECT) sequence. [0044] FIGURE 22 depicts examples of pulse sequences. [0045] FIGURE 23 depicts an example of a coil geometry (e.g., for a gradient coil and/or any other coil). [