EP-4739271-A1 - COMPOSITION FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS

Abstract

The invention relates to a dermatological or dermo-cosmetic composition in the form of a paraffin-free emulsion, particularly suitable for the treatment of inflammatory skin disorders, in particular on sensitive or atopic skin. Said composition comprises an aqueous phase containing at least one emollient selected among polyols, and an oil phase containing an oily emollient system comprising at least 70% by weight safflower oil and a second oily emollient.

Inventors

• DURAN, Violaine
• BOURNET, Estelle

Assignees

• Pierre Fabre Dermo-Cosmétique

Dates

Publication Date

20260513

Application Date

20240628

Claims (13)

1. 1. Dermatological or dermo-cosmetic composition in the form of an emulsion comprising: - an aqueous phase containing at least one emollient chosen from glycerin and its derivatives and glycols and their derivatives, - and an oily phase containing an oily emollient system comprising safflower oil and a second oily emollient, said composition containing at least 50% by weight of water relative to the total weight of the composition, and being characterized in that it contains, by weight relative to the total weight of the composition: - 10 to 20% in total of emollient(s) contained in the aqueous phase, - 10 to 25% of said oily emollient system, including 8 to 18% of safflower oil, the safflower oil representing more than 70% by weight of said oily emollient system, and said composition being free of paraffin.
2. 2. Composition according to claim 1, containing at least one consistency factor.
3. 3. Composition according to claim 1 or 2, in the form of an oil-in-water emulsion.
4. 4. Composition according to any one of claims 1 to 3, containing an emulsifying agent.
5. 5. Composition according to any one of claims 1 to 4, in which said emollient chosen from glycerin and its derivatives and glycols and their derivatives is glycerin.
6. 6. Composition according to any one of claims 1 to 5, in which said second oily emollient is chosen from triglycerides.
7. 7. Composition according to any one of claims 1 to 6, containing less than 6 oily emollients.
8. 8. Composition according to any one of claims 1 to 7, presented in a form suitable for topical application.
9. 9. Composition according to any one of claims 1 to 8, containing a dermo-cosmetic active ingredient.
10. 10. Composition according to claim 9, in which said dermo-active cosmetic is a non-pathogenic bacterium of the Neisseriaceae family as deposited with the CNCM under number CNCM 1-4290 or one of its mutants, and/or a bacterial extract obtained from a suspension of such a bacterium or one of its mutants.
11. 11. Composition according to any one of claims 1 to 10 for its use in the treatment of an inflammatory skin disorder.
12. 12. Composition for use according to claim 11, wherein said inflammatory skin disorder is atopic dermatitis, pruritus, eczema, psoriasis or rosacea.
13. 13. Composition for its use according to claim 11 or 12, to prevent a reduction in and/or strengthen the epidermal barrier function.

Description

COMPOSITION FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS The present invention falls within the field of dermatological or dermo-cosmetic compositions for the treatment of sensitive skin, in particular skin with inflammatory disorders, such as atopic or atopic-prone skin. More particularly, the present invention relates to a dermatological or dermo-cosmetic composition in the form of an emulsion, in particular of the oil-in-water type, particularly suitable for such treatment, as well as its use for the treatment of the skin, in particular of an inflammatory skin disorder. For over half a century, the use of skin and hair care products has gradually become a daily gesture, due to the pleasant sensation provided, the immediate comfort provided, the ease of use and the improvement in the quality of the skin and hair. Thus, a large number of products, emulsions in particular, have been developed, which appear in the form of different textures and galenics. Developments in chemistry have made it possible to provide new raw materials, more or less natural, to reinforce the cosmetic pleasure and improve the protection of these products through preservation. Cosmetic emulsions are composed of two phases: an aqueous phase composed of water and aqueous extracts, among other things, and an oily phase composed of oils, waxes, butters and fatty alcohol, among other things. The two phases are emulsified using surfactants or emulsifying agents. Then, active ingredients, solvents, humectants, texturizing agents, emollients, gelling agents, antioxidants, sequestering agents, fillers, preservatives, perfumes, dyes, pigments, sunscreens, etc. are added. All these ingredients are essential for the sensory experience, i.e. the pleasure and perception, the color, the smell of the product, the stability of the whole, its protection over time, and its immediate and longer-term cosmetic effectiveness. However, it has recently been shown that some of these ingredients are not useful for the skin, or even that they can be harmful to it, sometimes causing irritation, allergies, or even being endocrine disruptors. The skin and scalp are living and permeable membranes. There is therefore a risk that certain molecules will penetrate them, alter them and even pass into the subcutaneous blood network. Regulations, especially in Europe, have recently aimed to ban or reduce the use of some of them, whose associated risks are proven or suspected. Furthermore, in recent years, consumers have been increasingly vigilant about the composition of the products they buy. A growing number of ingredients are the subject of sometimes controversial questions, encouraged by the media, whether conventional or not. Thus, ingredients derived from petrochemicals, such as paraffin or petroleum jelly, are considered harmful to the environment. However, they are still widely used in cosmetics, because they help produce a protective layer on the skin. They also add thickness and texture to the compositions in which they are incorporated, and give them good sensory properties. The extracts from the GNPD database, Mintel No. 9882210 and Mintel No. 8424973, and the document WO 2016/051086 describe cosmetic compositions for skin care, in the form of an emulsion, free of paraffin. These compositions contain an aqueous phase comprising at least one aqueous emollient, and an oily emollient system containing safflower oil in an amount less than or equal to 50% by weight relative to the total weight of this system. None of these compositions is indicated for the treatment of inflammatory skin disorders. In general, the present invention aims to provide a dermatological or dermo-cosmetic composition in the form of an emulsion which is respectful of the skin, and in particular does not contain controversial substances, such as paraffin, while having sensorial properties at least as good as those of the compositions of the prior art containing such substances, and the cost price of which is not higher. More specifically, the invention aims to propose such a composition capable of providing benefits to sensitive skin, such as atopic or atopic-prone skin, and in particular capable of effectively treating inflammatory skin disorders. The skin is a protective envelope that covers the entire body. It is covered with a hydrolipidic protective film, made of a mixture of secretions such as sweat and sebum. The skin plays an essential role in protection, and it also acts as a communication interface between the body and its surrounding environment, thanks to the many tactile, thermal and nociceptor receptors it contains. The skin is composed of three layers, the epidermis, the dermis and the hypodermis (going from the outside to the inside of the body). The epidermis in particular is formed of a stratified, squamous, keratinized epithelium. It is mainly composed of keratinocytes, which proliferate and differentiate continuously. There are 4 different layers in the epidermis,