EP-4739682-A1 - 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS

Abstract

The invention relates to pharmaceutical compounds and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of the SMARCA2 protein and to their use in the treatment of SMARCA4 deficient cancers, e.g., SMARCA4 deficient non-small cell lung cancer (NSCLC).

Inventors

• STANSFIELD, IAN
• CALLAS, Christopher George
• WINTERS, MICHAEL PETER
• ROSANO, Robert J
• KRAWCZUK, Paul John
• BERTHELOT, Didier Jean Claude
• MEVELLEC, LAURENCE, ANNE
• PANDE, Vineet
• De Boeck, Benoît Christian Albert Ghislain
• BRAMBILLA, Marta
• JONES, Alexander Xenophon
• ALCÁZAR VACA, MANUEL JESÚS
• JONES, WILLIAM MOORE
• SHIMKIN, Kirk Wayne

Assignees

• Janssen Pharmaceutica NV

Dates

Publication Date

20260513

Application Date

20230705

Claims (20)

1. 1. A compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein R 1 is an optionally substituted phenyl selected from: (a) 2-chlorophenyl, 2-methyl-5-(lH-tetrazol-l-yl)phenyl, 5-(tert-butyl)-2- methoxyphenyl, 3-fluoro-2-(lH-l,2,3-triazol-l-yl)phenyl, 2-fluoro-5-(l- wherein R a is selected from: H; halo; C1-4alkyl; C1-4alkyl substituted with one or two members each independently selected from OH, cyclopropyl, CN, and CH2CO2C1-4alkyl; C1-4haloalkyk C1-4haloalkyl substituted with one or two OH members; CN; OC1-4alkyl; OC1-4haloalkyk (P=O)(CH3)2; CO2C1-4alkyl; NH(SO2-C2-3alkenyl), and NH(C=O)C2-3alkynyl; R b is selected from: Cl, F, Br, C1-4alkyl, OC1-4alkyl, cyclopropyl, and 4-methyl-lH- imidazol-l-yl; R c is selected from: Cl, Br, I, C1-4alkyl, C1-4haloalkyl, OC1-4alkyl, O-CH2CH2OH, C(OH)(CH 3 )2, (C=O)CF 3 , CN, C(CH 3 ) 2 CN, N(CH3)(CH 2 CH 2 OH), N(SO2CH3)(CH 2 CH 2 OH), CH(OH)(CH 3 ), CH(OH)(OCH 3 ), heterocycloalkyl optionally substituted with one or two members each independently selected from halo, OH, CH3, CH2CH2OH, OC1-4alkyl, and CO2C1-4alkyl; R d is Cl or CH 3 ; R e is selected from: C1-4alkyl substituted with one or two OH members, and IH-tetrazole; R g is C1-4alkyl optionally substituted with one OH member; R h is C1-4alkyl, or C1-4haloalkyl; R 1 is selected from: C1-4alkyl optionally independently substituted with one, two or three members selected from: OH, CN, OC1-4alkyl, CN, NH2, N(C1-4alkyl)2, O-tetrahydropyranyl, piperidine substituted with C(OH)(CH3)2, and NH(CO 2 C1-4alkyl); NH(C1-4alkyl); N(C1-4alkyl) 2 ; NH(CH 2 CH 2 OH); tetrahydropyranyl; C1-4haloalkyl; C2-4alkenyl; azetidine optionally substituted with OH; and (cis)-2,6-dimethylmorpholinyl; each R k is independently selected from: halo, C1-4akyl, OC1-4alkyl, NH2, OC1-4haloalkyl, CN, CH2OH, Cs-ecyclalkyl, and C2-4alkenyl; R m is selected from: C1-4haloalkyl, CH2CH2OH, and CH2CN; n is 0, 1, 2, or 3; X is O, NH, orN-CHs; R 3 is selected from: H, and C1-4alkyl optionally substituted with one member selected from: OH, NH2, N(CH3)2, NH(C=O)CH3, and morpholine; and R 5 is selected from the group consisting of: i) a 5- or 6-membered heteroaryl, optionally fused with a Cs-vcycloalkyl or Cs-vheterocycloalkyl, selected from: (cis)-2,6-dimethyl-4-(5,6,7,8-tetrahydro-2,6-naphthyridin-l-yl)morpholine; 7- ((cis)-2,6-dimethylmorpholino)-2,3-dihydrofuro[2,3-c]pyridine; 4-((cis)-2,6- dimethylmorpholino)-l,3-dihydrofuro[3,4-c]pyridine; (cis)-2,6-dimethyl-4- (5,6,7,8-tetrahydroisoquinolin-l-yl)morpholine; 3-((2,2,6,6-tetramethyltetrahydro- 2H-pyran-4-yl)oxy)pyridazin-6-yl; (cis)-2,6-dimethyl-4-(pyrimidin-4- yl)morpholine; (cis)-2,6-dimethyl-4-(lH-pyrazol-3-yl)morpholine; (IH-pyrazol-l- yi); R p is selected from the group consisting of: (a) an eight to ten membered nitrogen linked spirocyclic heterocycloalkyl ring system, wherein each ring optionally contains one, two or three heteroatoms each independently selected from N, O, and S, optionally substituted with one, two or three members each independently selected from: OH, C1-4alkyl, Ci- dialoalkyl, oxo, CO2C1-4alkyl, NH2, N(H)(C1-4alkyl), N(C1-4alkyl)2, N(H)(CO 2 C1-4alkyl), and OC1-4alkyl; (c) Nitrogen linked azetidine optionally substituted with a one or two members each independently selected from: CH3, NH2, and NH(CO2C1-4alkyl); Nitrogen linked pyrrolidine optionally substituted with one, two, three or four members each independently selected from: halo, C1-4alkyl, CH2OH, CH2OCH3, C1-4haloalkyl, OH, NH2, oxo, NH(CO2C1-4alkyl), morpholinyl, and CH2- morpholinyl; Nitrogen linked piperidine optionally substituted with one, two, three or four members each independently selected from: deuterium, halo, Ci- 4alkyl, CH2OH, CH2CH2OH, OH, NH2, NH(C1-4alkyl), and OC1-4alkyl; Nitrogen linked piperazine optionally substituted with one, two, three or four members each independently selected from: halo, C1-4alkyl, CH2OH, CH2CH2OH, CH2OCH3, CH2CH2OCH3, CH2CN, (C=O)NH 2 , CH 2 (C=O)NH 2 , CChC1-4alkyl, CH2SO2CH3, C1-4haloalkyl. OH, oxo, Cs-ecycloalkyl, and CH2-C3- ecycloalkyl; Nitrogen linked morpholine optionally substituted with one, two, three or four members each independently selected from: Cwalkyl, Ci- 4haloalkyl, CO2OH, oxo, (CH 2 )4-6-NH 2 , (CH 2 )4-6-NH(C=O)CH 3 , and (CH 2 )4-6- NH(CO 2 CI-4 alkyl); Nitrogen linked diazepane optionally substituted with one or two members Ci- 4alkyl members; Nitrogen linked oxazepane optionally substituted with one or two C1-4alkyl members; and Nitrogen linked thiomorpholine 1,1-dioxide; and (d) 5-10 membered fused or bridged ring, wherein each ring optionally contains one, two or three heteroatoms each independently selected from N, S, or O, optionally substituted with one, two or three members each independently selected from: halo, C1-4alkyl, OH, NH2, NH(C1-4alkyl), N(C1-4alkyl)2, NH(CO2C1-4alkyl), CO2C1-4alkyl, and oxo; each R q is independently selected from: H, halo, Cwalkyl, Cwhaloalkyl, CN, R s is H or halo; and R l is selected from: C1-4alkyl; oxetan-3-yl; carbon linked azetidine optionally substituted with (CCh-tBu); tetrahydropyran; l,3-oxazinan-2-one; 2, 2,6,6- tetramethylpiperidin-4-yl; and 2,2,6,6-tetramethyltetrahydro-2H-pyran; R u is H, pyridin-3-yl, or pyridin-4-yl; R v is (cis)-2,6-dimethylmorpholinyl, pyridin-3-yl, or pyridin-4-yl; R w is H, F, or OCHs; R x is pyridin-3-yl, or pyridin-4-yl; R y is selected from: , pyridin-3-yl, and pyridin-4-yl; R z is selected from: vi) a C1-4haloalkyl; or -CH2-R aa , wherein R aa is selected from: CH(CH3)2, CH2CH2OCH3,
2. 2. A compound of claim 1 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein: (i) R 1 is: (ii) R 1 is: (iii) R 1 is:
3. 3. A compound of claim 1 or a pharmaceutically acceptable salt, stereoisomer, or isotopic
4. 4. A compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt, stereoisomer or isotopic variant thereof, wherein R 3 is:
5. 5. A compound of any one of claims 1 to 4 or a pharmaceutically acceptable salt, stereoisomer or isotopic variant thereof, wherein:
6. 6. A compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein R 5 is:
7. 7. A compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein:
8. 8. A compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein wherein: (i) RP is (iii) R p is (iv) R p is
9. 9. A compound of claim 8 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein R q is: H, Cl, F, I, CHs, CN, CH2OH, CH(OH)(CH3), CO2H,
10. 10. A compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt, stereoisomer, or isotopic variant thereof, wherein:
11. 11. A compound of claim 1 selected from the group consisting of: N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((trifluoromethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-4-methyl-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(l -hydroxy ethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; 3-cyano-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-(l,l-difluoroethyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)(methyl)amino)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(N-(2-hydroxyethyl)methylsulfonamido)-4-methylbenzamide 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((3-methoxypropyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-l-hydroxyethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*S)-l-hydroxyethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-((tetrahydro-2H-pyran-4-yl)sulfonyl)benzamide; 4-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-(methylsulfonyl)benzamide; 3-(l,l-difluoroethyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-fluorobenzamide; 3-(l,l-difluoroethyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-ethoxybenzamide; 3-(cyclopropyl(hydroxy)methyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyridin-7 -yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(isopropylsulfonyl)-4,5-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(N,N-dimethylsulfamoyl)-4,5-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(N-(2 -hydroxy ethyl)-N-methylsulfamoyl)-4, 5- dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3,4-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-iodo-4,5-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(2-hydroxyethoxy)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3,4-dimethyl-5-(morpholinosulfonyl)benzamide; methyl 2-(3-(((2-(6-((cis)-2,6-dimethylmorpholino)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)carbamoyl)phenyl)acetate; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(2,2,2-trifluoroacetyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-ethoxyethyl)sulfonyl)-4,5-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-5-(l-hydroxyethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-5-((*R)-l -hydroxy ethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-5-((*S)-l-hydroxyethyl)-4-methylbenzamide; 4-cyclopropyl-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthy ridin-7-y l)methyl)-3 -( 1 -hydroxy ethyl)benzamide; 4-cyclopropyl-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-3-((*R)- 1 -hydroxy ethyl)benzami de; 4-cyclopropyl-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((*S)-l -hy droxy ethyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-methoxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-iodo-4-methylbenzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-(2-hydroxypropan-2-yl)benzamide; N-((2-(6-(4-(2-hy droxy ethyl)piperidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2,2-dioxido-2-thia-6-azaspiro[3.3]heptan-6-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l,4-oxazepan-4-yl)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l-oxa-7-azaspiro[3.5]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((lR,5S,8r)-8-hydroxy-3-azabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((lR,5S,8s )-8-hydroxy-3-azabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4-hydroxy-4-methylpiperi din-1 -yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l,l-dioxidothiomorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l,l-dioxido-l-thia-6-azaspiro[3.3]heptan-6-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-( 1 -oxa-6-azaspiro[3.3]heptan-6-y l)pyridin-2-yl)- 1 ,6-naphthy ridin-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(2-(trifluoromethyl)morpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(6-oxa- 1 -azaspiro[3.3]heptan- 1 -y l)pyridin-2-yl)- 1 ,6-naphthy ridin-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide ; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(2,2,6,6-tetramethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((lR,5S,6s )-6-hydroxy-3-azabicyclo[3.1. l]heptan-3-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5-oxa-8-azaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-morpholinopyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(2,2-dimethyl-l,4-oxazepan-4-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(7,7-dimethyl-l,4-oxazepan-4-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-((cis)-2,6-dimethylmorpholino)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3- (methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-ethyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4-hydroxy-3-methylpiperidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide ; N-((2-(6-((3*R,4*S)-4-hydroxy-3-methylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3*S,4*R)-4-hydroxy-3-methylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(methylsulfonyl)benzamide; 4-cyclopropyl-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3,4-dimethyl-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-methylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-methylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3-iodopyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3-(trifluoromethyl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((3-hydroxypropyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-((2-methoxyethyl)sulfonyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-5-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-(l-hydroxyethyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-(hydroxymethyl)-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3-methylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-cyclopropyl-3-(methylsulfonyl)-N-((2-(6-(2, 2,6,6- tetramethylmorpholino)py ridin-2-y 1)- 1 ,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-cyclopropyl-3-(methylsulfonyl)benzamide; N-((2-(7-((cis)-2,6-dimethylmorpholino)-2,3-dihydrofuro[2,3-c]pyridin-5-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(2,2,2-trifluoro- 1 , 1 -dihydroxyethyl)benzamide; N-((2-(6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3,4-dimethyl-5-(methylsulfonyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-(l-hydroxyethyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-5-((*R)-l -hydroxy ethyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7 -yl)methyl)-5-((* S)- 1 -hydroxy ethyl)benzami de; N-((2-(6-((lR,5S)-3-oxa-7,9-diazabicyclo[3.3.1]nonan-9-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-cyclopropyl-3-(methylsulfonyl)benzamide; 4-cyclopropyl-N-((2-(6-((lR,5S)-7-methyl-3-oxa-7,9-diazabicyclo[3.3.1]nonan- 9-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3- (methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(2-hydroxypropan-2-yl)-4-methylbenzamide; N-((2-(6-(6-oxa-3-azabicyclo[3. l.l]heptan-3-yl)pyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3,4-dimethyl-5-(methylsulfonyl)benzamide; 4-cyclopropyl-N-((2-(6-((3*S,4*R)-4-hydroxy-3-methylpiperidin-l-yl)pyri din-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-cyclopropyl-N-((2-(6-((3*R,4*S)-4-hydroxy-3-methylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-((3*S,4*R)-4-hydroxy-3-methylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-2,3-dimethyl-5-(methylsulfonyl)benzamide; N-((2-(6-((3*R,4*S)-4-hydroxy-3-methylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-2,3-dimethyl-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(methylsulfonyl)-4-(trifluoromethyl)benzamide; N-((2-(l-((cis)-2,6-dimethylmorpholino)-5,6,7,8-tetrahydroisoquinolin-3-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-((cis)-2,6-dimethylmorpholino)-l,3-dihydrofuro[3,4-c]pyridin-6-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 2-fluoro-4-methyl-5-(methylsulfonyl)-N-((2-(6-(2, 2,6,6- tetramethylmorpholino)py ridin-2-y 1)- 1 ,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-4-cyclopropyl-3-(methylsulfonyl)benzamide; 2-fluoro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-5-(methylsulfonyl)benzamide; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(l -hydroxy ethyl)benzamide; methyl 3-(((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)carbamoyl)benzoate; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; 3-((*S)-cyclopropyl(hydroxy)methyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 , 6-naphthyri din- 7 -yl)methyl)benzamide; 3-((*R)-cyclopropyl(hydroxy)methyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 , 6-naphthyri din- 7 -yl)methyl)benzamide; N-((2-(6-((3a,4a,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; 4-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l, 6-naphthyri din-7-yl)methyl)-3-(methylsulfonyl)benzami de; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-3-((*R)-l -hydroxy ethyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-3-((* S)- 1 -hydroxyethyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4,5-dimethylbenzamide; (5-(((2-(6-((cis)-2,6-dimethylmorpholino)pyri din-2 -yl)-l, 6-naphthyri din-7- yl)methyl)carbamoyl)-2,3-dimethylphenyl)boronic acid; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l, 6-naphthyri din-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)-4- methylbenzamide; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l, 6-naphthyri din-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3-fluoropyri din-2 -yl)-l, 6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (lR,5S)-9-(6-(7-((3,4-dimethyl-5-(methylsulfonyl)benzamido)methyl)- 1, 6-naphthyri din-2-yl)pyridin-2-yl)-3-oxa-7,9-diazabicyclo[3.3. l]nonane-7- carboxylate; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((methylsulfonyl)methyl)benzamide; N-((2-(3,5-dichloro-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-cyano-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-cyclopropyl-3-(N,N-dimethylsulfamoyl)-N-((2-(6-(2, 2,6,6- tetramethylmorpholino)py ridin-2-y 1)- 1 ,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-l -methoxy ethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*S)-l -methoxy ethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(l -methoxy ethyl)-4-methylbenzamide; N-((2-(6-((lR,5S)-3-oxa-7,9-diazabicyclo[3.3.1]nonan-9-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3,4-dimethyl-5-(methylsulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-methoxy-4-(4-methyl-lH-imidazol-l- yl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-methyl-5-(lH-tetrazol-l-yl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-2-methyl-5-(lH-tetrazol-l-yl)benzamide; 3-fluoro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- y 1)- 1 ,6-naphthy ri din-7 -y l)methyl)-2-( 1H- 1 ,2,3-triazol- 1 -yl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-methoxy-2-methyl-4- (methylsulfonyl)benzamide; 3-cyano-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyri din-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-methoxy benzamide; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 2-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-isopropylbenzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(2-hydroxyethyl)benzamide; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-4-methylbenzamide; 3-(difluoromethyl)-4-fluoro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5- dimethylpiperidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3,4-dichloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 5-(tert-butyl)-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-2-methoxybenzamide; 4-bromo-3-cyano-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-bromo-4-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-iodo-4-(trifluoromethyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3,4-dimethoxybenzamide; N-((2-(6-((3a, 4a, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((*R)-l-hydroxyethyl)-4-methylbenzamide; N-((2-(6-((3a, 4a, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((*S)-l -hydroxy ethyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-fluoro-4-methylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3,4-dimethylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-methoxy-3,5-dimethylpiperi din-1 -yl)pyri din-2 -yl)-l, 6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(3-hydroxyazetidin-3-yl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(4-hydroxypiperidin-4-yl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyri din- 7-yl)methyl)-3-((*R)-l -hydroxy ethyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyri din- 7 -yl)methyl)-3-((* S)- 1 -hydroxy ethyl)benzami de; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-5-((*R)- 1 -hydroxy ethyl)benzami de; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-5-((* S)- 1 -hydroxy ethyl)benzami de; 4-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7-yl)methyl)-3-(3-hy droxy azetidin-3-yl)benzamide; N-((2-(3-chloro-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(5-chloro-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-(2-cyanopropan-2-yl)-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin- 1 -y l)py ridin-2-y 1)- 1 , 6-naphthyri din- 7 -y l)methyl)benzamide; N-((*R)-l-(2-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)ethyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*S)-l-(2-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)ethyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-((diethylamino)methyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4,5-dimethylbenzamide; tert-butyl (4-((2*S,6*R)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)butyl)carbamate; tert-butyl (4-((2*R,6*S)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)butyl)carbamate; methyl 2-((cis)-2,6-dimethylmorpholino)-6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2-yl)isonicotinate; N-((2-(6-((2*S,6*R)-2-(4-aminobutyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*R,6*S)-2-(4-aminobutyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 2-((cis)-2,6-dimethylmorpholino)-6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l,6-naphthyridin-2-yl)isonicotinic acid; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-(hydroxymethyl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(3-hydroxypyrrolidin-l-yl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(((*R)-2-hydroxypropyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(((*S)-2-hydroxypropyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((2*S,6*R)-2-(4-acetamidobutyl)-6-methylmorpholino)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*R,6*S)-2-(4-acetamidobutyl)-6-methylmorpholino)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-(aminomethyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4,5-dimethylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-((*S)-morpholin-2-yl)benzamide; N-((2-(6-((cis)-3,5-dimethylpiperazin-l-yl)pyri din-2 -yl)-l, 6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*S)-3-hydroxypiperidin-3-yl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-(l-hydroxyethyl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 2-((cis)-2,6-dimethylmorpholino)-6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l,6-naphthyridin-2-yl)isonicotinamide; (R)-N-((2-(6-(2-(hydroxymethyl)pyrrolidin-l-yl)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (S)-N-((2-(6-(2-(hydroxymethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2,5-dioxa-8-azaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-5-(methylsulfonyl)-2-vinylbenzamide; 3-chloro-N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)-3- methylpyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)-5- (methylsulfonyl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-(2-hydroxyethyl)-3-(methylsulfonyl)benzamide; N-((2-(4-cyano-6-((cis)-2,6-dimethylmorpholino)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(5-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-((cis)-2,6-dimethylmorpholino)-2-fluorophenyl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-((cis)-2,6-dimethylmorpholino)-2,4-difluorophenyl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-morpholinobenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(tetrahydrofuran-2-yl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3,4-dimethyl-5-((4-methylpiperazin-l-yl)methyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyrazin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-3-((*R)- 1 -hydroxy ethyl)-4-methylbenzami de; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((*S)-l -hydroxy ethyl)-4-methylbenzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7- yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)phenyl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(4-fluoro-3-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7-yl)methyl)-4-methyl- 3-(methylsulfonyl)benzamide; N-((2-(2-fluoro-3-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7-yl)methyl)-4-methyl- 3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(7-(pyridin-4-yl)-2,3-dihydrobenzofuran-5- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(2-methoxy-5-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; N-((2-(3-fluoro-5-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7-yl)methyl)-4-methyl- 3-(methylsulfonyl)benzamide; N-((2-(6-((3S,4s,5R)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,6-dihydro-2H-pyran-3-yl)pyri din-2 -yl)-l, 6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(l'-(cyclopropanecarbonyl)-r,2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5-oxa-2,8-diazaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-4-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(3-((cis)-2,6-dimethylmorpholino)-6-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)pyrrolidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-4-yl)piperazin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-3-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-3-yl)piperazin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(9-oxa-2-azaspiro[5.5]undecan-2-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-4-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(3-(4-(2-hydroxypropan-2-yl)phenyl)piperidin-l-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-4-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(l'-(4-fluorobutanoyl)-r,2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-3-yl)phenyl)-l,6-naphthyridin-7- yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(l-(pyridin-3-yl)piperidin-4-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)pyrrolidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)pyrrolidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-4-yl)phenyl)-l,6-naphthyridin-7- yl)methyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-4-yl)pyrrolidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-4-yl)pyrrolidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(tetrahydro-2H-pyran-3-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(2-(pyridin-4-yl)morpholino)-l,6- naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(2-(pyridin-4-yl)morpholino)-l,6- naphthyridin-7-yl)methyl)benzamide; 3-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-5-(l -hy droxyethyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-nicotinoylpiperazin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(4-acetylpiperazin- 1 -yl)- 1 ,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(2-oxopiperidin- 1 -yl)- 1 ,6-naphthy ridin-7 - yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridazin-3-yl)piperazin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(4-isonicotinoylpiperazin-l-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; N-((2-(4-(6-methoxypyridin-3-yl)piperazin-l-yl)-l,6-naphthyridin-7-yl)methyl)- 4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(6-oxo-l,6-dihydropyridin-3-yl)piperazin- l-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyrazin-2-yl)piperazin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(4-(6-aminopyridin-3-yl)piperazin-l-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(3-(pyridin-3-yl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(4-(2-hydroxy-2-methylpropanoyl)piperazin-l-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(4-(l-methyl-lH-pyrazol-4-yl)piperazin-l-yl)-l,6-naphthyridin- 7-yl)methyl)-3-(methylsulfonyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(l-(pyridin-3-yl)piperidin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(l-(pyridin-3-yl)piperidin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(3 -((cis)-2,6-dimethy lmorpholine-4-carbonyl)cy clohex- 1 -en- 1 -yl)- 1,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; ethyl l-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6-naphthyridin-2- yl)piperidine-3-carboxylate; (*R)-N-((2-(3-(4-(2-hydroxypropan-2-yl)phenyl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(3-(4-(2-hydroxypropan-2-yl)phenyl)piperidin-l-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(lH-pyrazol-l-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; N-((2-(3-((cis)-2,6-dimethylmorpholino)- IH-py razol- 1 -y 1)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(4-methyl-3 -(pyridin-4-yl)piperazin- 1 -yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-3-(methylsulfonyl)benzamide; 1 -(7 -((4-methyl-3 -(methylsulfonyl)benzamido)methyl)- 1 ,6-naphthyridin-2- yl)piperidine-3-carboxylic acid; N-((2-(6-(((2R,4r,6S)-2,6-dimethyltetrahydro-2H-pyran-4-yl)oxy)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-hydroxy ethoxy )pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(l-(pyridin-4-yl)piperidin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(3,3-dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-chloro-6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; (R)-N-((2-(6-(2-(methoxymethyl)pyrrolidin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-(difluoromethyl)-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-(6-aminopyridin-3-yl)piperidin-l-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(4-(pyridin-4-yl)azepan-l-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-2-fluoro-5-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; (S)-N-((2-(6-(2-(methoxymethyl)pyrrolidin-l-yl)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-5- methylbenzamide; tert-butyl 7-(4-fluoro-6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)- l,6-naphthyridin-2-yl)pyridin-2-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate; N-((2-(4-((cis)-2,6-dimethylmorpholino)pyrimidin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,8-diazaspiro[2.6]nonan-5-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4-hydroxy-3,3-dimethylpiperi din-1 -yl)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(tetrahydrofuran-2-yl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-(2-hydroxypropan-2-yl)-4-methylbenzamide; 3-chloro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5] octan-7 -yl)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-4-methyl-5-(methylsulfonyl)benzamide; N-((2-(4-(5-aminopyridin-3-yl)piperazin-l-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; N-((2-(5-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; 4-methy l-N-((2-(6-(6-methyl-4,7 -diazaspiro [2.5] octan-7-yl)py ri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(6-ethyl-4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-(hy droxymethyl)piperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (R)-N-((2-(6-(2-(hydroxymethyl)piperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyri din- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-isopropylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)- 4-methyl-3-(methylsulfonyl)benzamide; (R)-4-methyl-N-((2-(6-(2-methylpiperazin- 1 -yl)pyri din-2 -yl)- 1 ,6-naphthyri din- 7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(2-ethylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide N-((2-(6-(3-(methoxymethyl)piperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2R,5S)-5-ethyl-2-methylpiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; methyl 4-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyri din-2 -yl)pyri din-2 -yl)piperazine-2-carboxylate; N-((2-(6-((2S,5R)-5-ethyl-2-methylpiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide (S)-4-methyl-N-((2-(6-(2-methylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-3-(methylsulfonyl)benzamide; 4-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6-naphthyridin-2- yl)pyridin-2-yl)piperazine-2-carboxamide; N-((2-(6-((cis)-2,6-dimethylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2S,5R)-2,5-dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (S)-N-((2-(6-(3-(cyanomethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (S)-N-((2-(6-(3-(hydroxymethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (R)-N-((2-(6-(3-(hydroxymethyl)piperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3,8-diazabicyclo[3.2.1]octan-3-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3,8-diazabicyclo[3.2.1]octan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)-3- methylpyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3- (methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(2-(4,7-diazaspiro[2.5]octan-7-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4,5-dimethylpyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(5-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 4-chloro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5] octan-7 -yl)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(5-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4- methylbenzamide; N-((2-(6-(3-(2,2-difluoroethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-(difluoromethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l,4-diazepan-l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2,5-dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((4aR,7aS)-hexahydrofuro[3,4-b]pyrazin-l(2H)-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-cyclopropyl-3-methylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-cy clopropy Ipiperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (S)-4-methyl-N-((2-(6-(3-methylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(2-(methoxymethyl)piperazin-l-yl)pyri din-2 -yl)-l, 6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-(2,2-difluoroethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(piperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(2-(cyclopropylmethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,8-diazaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((2R,3R)-3-methyl-2-(trifluoromethyl)piperazin-l-yl)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(2-(2-methoxyethyl)piperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-(3-(2-(methylamino)-2-oxoethyl)piperazin-l-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-((4aS,7aR)-octahydro-lH- cyclopenta[b]pyrazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(2,5,5-trimethylpiperazin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; (R)-4-methyl-N-((2-(6-(3-methylpiperazin- 1 -yl)pyri din-2 -yl)- 1 ,6-naphthyridin- 7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(2-isopropylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)- 4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3,3-dimethyl-l,4-diazepan-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2,3-dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2S,3R)-2,3-dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((4aR,7aS)-6,6-dioxidohexahydrothieno[3,4-b]pyrazin-l(2H)- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(3-((methylsulfonyl)methyl)piperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; ethyl 3-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6-naphthyridin-2- yl)cyclobutane-l -carboxylate; 3-chloro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5] octan-7 -yl)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-(4-oxa-7-azaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,8-diazaspiro[3.6]decan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-3-hydroxypiperidin-3-yl)-4-methylbenzamide; 3-(N,N-dimethylsulfamoyl)-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methylbenzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(pyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; tert-butyl 3-((7 -((4-methyl-3-(methylsulfonyl)benzamido)methyl)- 1,6- naphthyridin-2-yl)methyl)pyrrolidine- 1 -carboxylate; 4-methyl-3-(methylsulfonyl)-N-((2-(tetrahydro-2H-pyran-4-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-((tetrahydro-2H-pyran-4-yl)methyl)-l,6- naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-((l-(pyrimidin-2-yl)piperidin-4-yl)methyl)- l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(cyclopentylmethyl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; N-((2-(l,l-dioxidotetrahydro-2H-thiopyran-4-yl)-l,6-naphthyridin-7-yl)methyl)- 4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(2-(methylsulfonyl)benzyl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(3-methoxypropyl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; 4-methyl-N-((2-(3-methylbenzyl)-l,6-naphthyridin-7-yl)methyl)-3- (methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(3,3,3-trifluoropropyl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-4-methoxy-3-(methylsulfonyl)benzamide ; N-((2-(4-(4-acetamidobutyl)-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-(4-aminobutyl)-6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-((3a, 4p, 5a))-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)-5- (trifluoromethoxy)benzamide; N-((2-(3-chloro-4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-(difluoromethoxy)-N-((2-(4-fluoro-6-((3S,4r,5R)-4-hydroxy-3,5- dimethylpiperi din-1 -yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5- (methylsulfonyl)benzamide; (*R)-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(tetrahydrofuran-2-yl)benzamide; (*S)-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(tetrahydrofuran-2-yl)benzamide; N-((2-(6-(3-hydroxy-3-methylpyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7 -y l)methyl)-3-((3 -hydroxy azeti din- 1 -yl)sulfonyl)-4-methy Ibenzamide; 3-chloro-N-((2-(4-fluoro-6-((3a, 4p, 5a))-4-hydroxy-3,5-dimethylpiperidin-l- yl)-3-methylpyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5- (methylsulfonyl)benzamide; N-((2-(6-(7-amino-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (3-methyl-l-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)- 1 ,6-naphthyridin-2-yl)pyridin-2-yl)azetidin-3-yl)carbamat e; tert-butyl 2-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyri din-2-yl)pyri din-2 -yl)-9-oxa-2,6-diazaspiro[4.5]decane-6- carboxylate; N-((2-(6-(9-oxa-2,6-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyri din-2- yl)-l,6-naphthyridin-7-yl)methyl)-4-methoxy-3-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5-((2- hy droxy ethyl)sulfonyl)benzamide; 3-fluoro-N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-5- (methylsulfonyl)benzamide ; 3-fluoro-N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5-((2-hy droxy ethyl)sulfonyl)- 4-methylbenzamide; N-((2-(4-fluoro-3-methyl-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(2-cyanopropan-2-yl)-4-fluorobenzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-chloro-3-(2-cyanopropan-2-yl)benzamide; 4-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-(3-methyl-5-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(5-oxo-4,7-diazaspiro[2.5]octan-7- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-fluoro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)benzamide; (*R)-N-((2-(6-(3-hydroxy-3-methylpyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(3-hydroxy-3-methylpyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-chloro-3-methyl-5-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(3-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; (*R)-N-((2-(6-(9-oxa-2,6-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(9-oxa-2,6-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl ((lR)-3-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyridin-2-yl)pyridin-2-yl)-3-azabicyclo[3.1.0]hexan-l-yl)carbamate; 4-methyl-N-((2-(6-(3-methyl-3-morpholinopyrrolidin- l-yl)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((3*R,4*R)-3-methyl-4-morpholinopyrrolidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((3*S,4*S)-3-methyl-4-morpholinopyrrolidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(7-amino-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(7-amino-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-chloro-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5] octan-7 -yl)pyri din-2 -yl)- 1,6- naphthyridin-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-methyl-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-methyl-5-(methylsulfonyl)benzamide; N-((2-(6-((3a, 4p, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-methyl-5-(methylsulfonyl)benzamide; N-((2-(6-(3-amino-3-(trifluoromethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((3*S,4*R)-3-methyl-4-morpholinopyrrolidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((3*R,4*S)-3-methyl-4-morpholinopyrrolidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; tert-butyl 2-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyridin-2-yl)pyri din-2 -yl)-8-oxa-2,5-di azaspiro[3.5]nonane-5- carboxylate; N-((2-(6-(3-amino-3-methylazetidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-cy clopropy Ipiperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-cyclobutylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-(difluoromethy l)piperazin- 1 -y l)pyridin-2-yl)- 1 ,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (S)-N-((2-(6-(3-isopropylpiperazin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(3-(2,2,2-trifluoroethyl)piperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-methyl-N-((2-(6-(3-methyl-4-morpholinopyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; tert-butyl 2-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyridin-2-yl)pyri din-2 -yl)-6-oxa-2,9-diazaspiro[4.5]decane-9- carboxylate; N-((2-(6-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(l-((cis)-2,6-dimethylmorpholino)-5,6,7,8-tetrahydro-2,6-naphthyridin-3- yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((lR)-l-(methylamino)-3-azabicyclo[3.1.0]hexan-3- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-(7-hy droxy-5-azaspiro[2.4]heptan-5-yl)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(8-amino-5 -azaspiro [2.5] octan-5-yl)pyridin-2-yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl 2-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyridin-2-yl)pyri din-2 -yl)-5-oxa-2,8-diazaspiro[3.5]nonane-8- carboxylate; N-((2-(6-(8-oxa-2,5-diazaspiro[3.5]nonan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide N-((2-(6-(4-amino-3 ,3 -difluoropiperidin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (5-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyridin-2-yl)pyridin-2-yl)-5-azaspiro[2.5]octan-8-yl)carbamate; N-((2-(6-(8-(dimethylamino)-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(7-hydroxy-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(7-hydroxy-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5-oxa-2,8-diazaspiro[3.5]nonan-2-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide 3 ,4-dimethy l-N-((2-(6-((l R,5 S)-7 -methyl-3 -oxa-7,9-diazabicy clo [3.3.1 ]nonan-9- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-(2-methyl-3-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-(2-methyl-5-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)-3-(methylsulfonyl)benzamide ; N-((2-(6-(3-ethyl-3-hydroxypyrroli din-1 -yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2,5,8-triazaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3-hydroxy-3-(trifluoromethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-chloro-3-(methylsulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; N-((2-(6-(l-oxa-6-azaspiro[3.4]octan-6-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4-hydroxy-3,3-dimethylpyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(4-amino-3,3-difluoropiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(4-amino-3,3-difluoropiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(6,9-dioxa-2-azaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(l-oxa-6-azaspiro[3.4]octan-6-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(l-oxa-6-azaspiro[3.4]octan-6-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-3-(dimethylphosphoryl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(3-hydroxy-3-(trifluoromethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(3-hydroxy-3-(trifluoromethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(3,3-difluoro-4-hydroxypyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(4-hydroxy-3,3-dimethylpyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(4-hydroxy-3,3-dimethylpyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(l-fluorocyclopropyl)pyrimidin-4-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; JV-(l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)- 5-hydroxypentyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-((tetrahydrofuran-2-yl)methoxy)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((2,6-dimethylpiperidin-4-yl)oxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((4,4-difluoropyrrolidin-3-yl)oxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((l-hydroxypropan-2-yl)oxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide and N-((2-(6-(2- hydroxypropoxy)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; N-((2-(6-(2-(cyclopropylamino)ethoxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(2-hydroxy-2-methylpropoxy)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(2-((2,2,2- trifluoroethyl)amino)ethoxy)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-((4-azaspiro[2.5]octan-7-yl)oxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((l-(methylamino)cyclopropyl)methoxy)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; N-((2-(6-((3,3-difluoropiperidin-4-yl)oxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-((2-(trifluoromethyl)piperidin-4- yl)oxy)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((3R,4s,5S)-4-(hydroxymethyl)-3,5-dimethylpiperidin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide ; N-((2-(6-(4-(2-hydroxyethyl)-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide ; N-((2-(6-(l-oxa-7-azaspiro[4.4]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (3-(((2-(4-fluoro-6-((3a, 4b,5a)-4-hydroxy-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)carbamoyl)-5- (methylsulfonyl)benzyl)carbamate; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(S-methylsulfonimidoyl)benzamide; N-((2-(6-((3a, 4p, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(S-methylsulfonimidoyl)benzamide; (*R)-N-((2-(6-(3,3-difluoro-4-hydroxypyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(3,3-difluoro-4-hydroxypyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2*R,4*S)-4-hydroxy-l-methylpyrrolidin-2-yl)-4- methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2*S,4*R)-4-hydroxy-l-methylpyrrolidin-2-yl)-4- methylbenzamide; 3-((3,3-difluoropropyl)sulfonyl)-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7- yl)pyridin-2-yl)-l, 6-naphthyri din-7-yl)methyl)-4-methylbenzamide; (*R)-N-((2-(6-(8-amino-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(8-amino-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-(aminomethyl)-N-((2-(4-fluoro-6-((3a, 4p,5a)-4-hydroxy-3,5- dimethylpiperi din-1 -yl)pyridin-2-yl)-l, 6-naphthyri din-7-yl)methyl)-5- (methylsulfonyl)benzamide; 3-((*R)-4,4-difluoropyrrolidin-2-yl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyri din-2 -yl)-l, 6-naphthyri din-7-yl)methyl)-4- methylbenzamide; N-((2-(3,4-dimethyl-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide 4-methyl-3-(methylsulfonyl)-N-((2-(6-(l -oxo-2, 7-diazaspiro[4.4]nonan-2- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(5-oxo-2,6-diazaspiro[3.4]octan-6- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(5-oxo-l,6-diazaspiro[3.4]octan-6- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-methyl-N-((2-(4-methyl-l-(4-azaspiro[2.5]octan-7-yl)-lH-pyrazol-3-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; tert-butyl (4,4-difluoro-l-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)pyrrolidin-3-yl)carbamate; 3-((*S)-4,4-difluoropyrrolidin-2-yl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyri din-2 -yl)-l, 6-naphthyri din-7-yl)methyl)-4- methylbenzamide; 3-chloro-5-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)-4-fluoropyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)benzamide; 3-chloro-5-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 , 6-naphthyri din- 7 -yl)methyl)benzamide; N-((2-(6-(2-oxa-7-azaspiro[4.4]nonan-7-yl)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-(8-hydroxy-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-((cis)-3-hydroxy-3,4-dimethylpyrrolidin-l-yl)pyridin-2-yl)- 1, 6-naphthyri din-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-(4-amino-3,3-difluoropyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (6-((2*R,6*S)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)hexyl)carbamate; tert-butyl (6-((2*S,6*R)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)hexyl)carbamate; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-4-methyl-3-(*R-methylsulfonimidoyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din-7- yl)methyl)-4-methyl-3-(*S-methylsulfonimidoyl)benzamide; # N-((2-(6-(2-(2-hy droxyethoxy)ethoxy)pyri din-2 -yl)- 1 , 6-naphthyri din-7 - yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*R,6*S)-2-(6-aminohexyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*S,6*R)-2-(6-aminohexyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*R)-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7-yl)-3-hydroxypropyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((* S)- 1 -(2-(6-((cis)-2,6-dimethylmorpholino)py ri din-2 -yl)- 1 , 6-naphthyri din-7- yl)-3-hydroxypropyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(l-hydroxy-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*R,6*S)-2-(5-aminopentyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*S,6*R)-2-(5-aminopentyl)-6-methylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; tert-butyl (5-((2*R,6*S)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)pentyl)carbamate; tert-butyl (5-((2*S,6*R)-6-methyl-4-(6-(7-((4-methyl-3- (methylsulfonyl)benzamido)methyl)-l, 6-naphthyri din-2 -yl)pyridin-2- yl)morpholin-2-yl)pentyl)carbamate; 3-(dimethylphosphoryl)-N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7- yl)pyridin-2-yl)-l, 6-naphthyri din-7-yl)methyl)benzamide; N-((2-(6-((2*R,6*S)-2-(5-acetamidopentyl)-6-methylmorpholino)pyridin-2-yl)- 1, 6-naphthyri din-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*S,6*R)-2-(5-acetamidopentyl)-6-methylmorpholino)pyridin-2-yl)- 1, 6-naphthyri din-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide N-((2-(6-((lR)-l-amino-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-(trans)-3-hydroxy-4-methyl-3-(trifluoromethyl)pyrrolidin-l- yl)pyridin-2-yl)-l, 6-naphthyri din-7-yl)methyl)-5-(methylsulfonyl)benzami de; 3-fluoro-N-((2-(6-(3-methoxy-3-methylpyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-(7-methoxy-5-azaspiro[2.4]heptan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-cyano-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l, 6-naphthyri din- 7 -y l)methyl)-4-methy Ibenzamide; N-((2-(6-(3,3-difluoro-4-(methylamino)piperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*R,6*S)-2-(6-acetamidohexyl)-6-methylmorpholino)pyridin-2-yl)- 1, 6-naphthyri din-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2*S,6*R)-2-(6-acetamidohexyl)-6-methylmorpholino)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-3-hydroxycyclobutoxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((trans)-3-hydroxycyclobutoxy)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(6,9-dioxa-2-azaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(6,9-dioxa-2-azaspiro[4.5]decan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3,4-dimethyl-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfinyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(2-(morpholinomethyl)pyrrolidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(2-oxa-5-azabicyclo[2.2. l]heptan-5-yl)pyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((*R)-5-amino-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)pentyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*S)-5-amino-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)pentyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(2-(4,7-diazaspiro[2.5]octan-7-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-3-(methylsulfonyl)-4-(trifluoromethyl)benzamide; N-((*R)-5-acetamido-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)pentyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*S)-5-acetamido-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)pentyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-((6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)amino)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; - 3-fluoro-N-((2-(6-((2S,4S)-4-hydroxy-2-(hydroxymethyl)-4- (trifluoromethyl)pyrrolidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)- 5-(methylsulfonyl)benzamide; N-((2-(6-(6-oxa-2-azaspiro[3.4]octan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; N-((2-(6-(5,8-dioxa-2-azaspiro[3.5]nonan-2-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; N-((2-(6-((3*S, 4*r,5*S)-4-(2 -hydroxy ethyl)-3,5-dimethylpiperi din-1 -yl)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3*S,4*s,5*R)-4-(2-hydroxyethyl)-3,5-dimethylpiperidin-l- yl)pyridine-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; N-((2-(6-((3*S,4*r,5*R)-4-(2-hydroxyethyl)-3,5-dimethylpiperidin-l- yl)pyridine-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; (*R)-N-((2-(6-(4-amino-3,3-difluoropyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(4-amino-3,3-difluoropyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3*R, *s,5*R)-4-(2 -hydroxy ethyl)-3,5-dimethylpiperi din-l-yl)pyri din- 2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-4-fluoro-3-(methylsulfonyl)benzamide; (*R)-3-fluoro-N-((2-(6-(8-hydroxy-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; (*S)-3-fluoro-N-((2-(6-(8-hydroxy-5-azaspiro[2.5]octan-5-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*S)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-((lR)-l-(dimethylamino)-3-azabicyclo[3.1.0]hexan-3-yl)pyri din-2 -yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-N-((2-(6-(3,3-difluoro-4-(methylamino)piperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(3,3-difluoro-4-(methylamino)piperi din-1 -yl)pyri din-2 -yl)-l, 6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*R)-4-methyl-3-(methylsulfonyl)-N-((2-(6-(2-(morpholinomethyl)pyrrolidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(6-(2-(morpholinomethyl)pyrrolidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((2-chloroethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)-4-methylbenzamide; N-((2-(6-(4-(2-hydroxypropan-2-yl)piperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-(4-(2 -hydroxypropan-2-yl)piperi din-1 -yl)-N-((2-(6-(4-(2-hydroxypropan-2- y l)piperidin- 1 -y l)pyri din-2 -yl)- 1 ,6-naphthy ridin-7-y l)methyl)-5 - (methylsulfonyl)benzamide; 3 -fluoro-N-((2-(6-(4-(2-hy droxypropan-2-yl)piperidin- 1 -yl)py ridin-2-yl)- 1,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-((2-(dimethylamino)ethyl)sulfonyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)-4- methylbenzamide; N-((2-(6-((( 3a, 4p, 5a))-4-hydroxy-3,5-dimethylpiperi din-1 -yl)methyl)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(((cis)-2,6-dimethylmorpholino)methyl)pyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-phenyl- 1 ,6-naphthyridin-7- yl)methyl)benzamide; tert-butyl 5-(6-(7-((4-methyl-3-(methylsulfonyl)benzamido)methyl)-l,6- naphthyri din-2-yl)pyri din-2 -yl)-2,5-diazabicyclo[4.1.0]heptane-2-carboxylate; (*R)-4-methyl-N-((2-(6-(8-(methylamino)-5-azaspiro[2.5]octan-5-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; (*S)-4-methyl-N-((2-(6-(8-(methylamino)-5-azaspiro[2.5]octan-5-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; (R)-3-fluoro-N-((2-(6-(2-methylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-(6-hydroxy-2-azaspiro[3.3]heptan-2-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-(2-hydroxy-7-azaspiro[3.5]nonan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; N-((2-(6-(2-oxa-7-azaspiro[3.5]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-((2s,4r)-2-hydroxy-6-azaspiro[3.4]octan-6-yl)pyridin-2-yl)- 1.6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(6-((2r,4s)-2-hydroxy-6-azaspiro[3.4]octan-6-yl)pyridin-2-yl)- 1.6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide ; N-((2-(6-((l*R,5*S)-l-hydroxy-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((l* S,5*R)-l-hydroxy-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)- 1.6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-fluoro-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(vinylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(vinylsulfonyl)benzamide; N-((*R)-3-(dimethylamino)-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)propyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*S)-3-(dimethylamino)-l -(2-(6-((cis)-2,6-dimethylmorpholino)pyri din-2 -yl)- 1.6-naphthyridin-7-yl)propyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((*R)-l-(2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)-3-morpholinopropyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((* S)- 1 -(2-(6-((cis)-2,6-dimethylmorpholino)py ri din-2 -yl)- 1 ,6-naphthyridin-7- yl)-3-morpholinopropyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(2-(4,7-diazaspiro[2.5]octan-7-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-4-(difluoromethyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((2*R,6*R)-2-methyl-6-(trifluoromethyl)morpholino)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((2*R,6*S)-2-methyl-6-(trifluoromethyl)morpholino)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((2*S,6*R)-2-methyl-6-(trifluoromethyl)morpholino)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 4-methyl-N-((2-(6-((2*S,6*S)-2-methyl-6-(trifluoromethyl)morpholino)pyridin- 2-yl)-l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-methyl-3-(S-methylsulfonimidoyl)benzamide; (*R)-N-((2-(6-(l-oxa-7-azaspiro[4.4]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; (*S)-N-((2-(6-(l-oxa-7-azaspiro[4.4]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-morpholinopyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3-((2- hydroxyethyl)sulfonyl)-4-methylbenzamide; 3-fluoro-N-((2-(6-((3a, 4p, 5a))-4-(hydroxymethyl)-3,5-dimethylpiperidin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 6-methyl-4-(6-(7 -((4-methyl-3-(methylsulfonyl)benzamido)methyl)- 1,6- naphthyridin-2-yl)pyridin-2-yl)morpholine-2-carboxylic acid; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-fluoro-3-(methylsulfonyl)benzamide N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-(2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; 3-((2-hydroxyethyl)sulfonyl)-4-methyl-N-((2-phenyl-l,6-naphthyridin-7- yl)methyl)benzamide; 3-fluoro-5-(methylsulfonyl)-N-((2-phenyl- 1 ,6-naphthyridin-7- yl)methyl)benzamide; 4-chloro-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-(S-methylsulfonimidoyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- y l)methyl)-3 -(prop- 1 -yn- 1 -y lsulfonamido)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(l ,4-dioxan-2-yl)-4-methylbenzamide. ; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-((*S)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-((*R)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperi din-l-yl-4-d)pyri din-2 -yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((3a,4a,5a))-4-hydroxy-3,5-dimethylpiperidin-l-yl-4-d)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(morpholino-d8)pyridin-2-yl)-l,6- naphthyri din-7 -yl)methyl)benzamide ; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(vinylsulfonamido)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(vinylsulfonyl)benzamide; N-((2-(6-((3a, 4p, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-((*R)-methylsulfinyl)benzamide; N-((2-(6-((3a, 4p, 5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-((*S)-methylsulfinyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-(2-hydroxyethyl)sulfinyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*S)-(2-hydroxyethyl)sulfinyl)-4-methylbenzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((3a,4p,5a))-4-hydroxy-3,5- dimethylpiperidin-l-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-(6,6-dimethy 1-5 -oxa-2, 8 - di azaspiro [3.5]nonan-2-yl)pyridin-2-yl)- 1 ,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-l,4-dioxan-2-yl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((*R)-l,4-dioxan-2-yl)-4-methylbenzamide; N-((2-(4-fluoro-6-(morpholino-d8)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)- 3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-(4-amino-3 ,3 -difluoropiperidin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthy ri din-7 - yl)methyl)-4-methyl-3-(S-methylsulfonimidoyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6-hydroxy-2-azaspiro[3.3]heptan-2- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(2-(4,7-diazaspiro[2.5]octan-7-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-3-(methylsulfinyl)-4-(trifluoromethyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-((3a,4p,5a)-4-hydroxy-3,5- dimethy Ipiperidin- 1 -yl)py rimidin-4-yl)- 1 ,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(6-hydroxy-2-azaspiro[3.3]heptan-2- yl)pyrimidin-4-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; N-((2-(2-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)pyrimidin-4-yl)-l,6-naphthyridin- 7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 4-methyl-3-(methylsulfonyl)-N-((2-(6-(5-oxo-4,6-diazaspiro[2.4]heptan-6- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-(S-(difluoromethyl)sulfonimidoyl)-N-((2-(4-fluoro-6-(4,7- diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-(S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropyri din-2 -yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-phenyl-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-4-fluoro-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(N,S-dimethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-(2,6-dimethylmorpholino-2,3,3,5,5,6-d6)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((4,7 -di azaspiro [2.5] octan-7-yl)methy l)py ri din-2 -y 1)- 1 ,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2S,5S)-2,5-dimethyl-3-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((2R,5R)-2,5-dimethyl-3-oxopiperazin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-methoxypyridin-3-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-isopropoxypyridin-3-yl)-l,6-naphthyridin- 7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(3-methyl-5-oxopiperazin-l-yl)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(3,4,4-trimethyl-2-oxoimidazolidin-l- y l)pyrimidin-4-yl)- 1 ,6-naphthy ri din-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(3,3-dimethyl-5-oxopiperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(2-(4-amino-3,3-difluoropiperidin-l-yl)pyrimidin-4-yl)-l,6-naphthyridin- 7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(2-hydroxy-7-azaspiro[3.5]nonan-7- yl)pyrimidin-4-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; N-((2-(6-(2,6-dimethylmorpholino-2,3,3,5,5,6-d6)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2 -hydroxy ethyl)sulfonyl)-4-(methyl- d3)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-(methyl-d3)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(5-fluoro-6-methoxypyridin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6,8-dioxo-2,5,7-triazaspiro[3.4]octan-2- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(3-amino-3-methyl-2-oxopyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,5-dimethyl-2-oxopiperazin-l-yl)pyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-(5,8-diazaspiro[3.5]nonan-8-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6-oxo-5,8-diazaspiro[3.5]nonan-8- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridin- 3-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyridin- 7 -y l)methyl)-3-( 1 , 1 ,2,2-tetrafluoroethoxy )benzamide; N-((2-(6-(2,6-dimethylmorpholino-2,3,3,5,5,6-d6)-4-fluoropyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2 -hydroxy ethyl-2,2-d2)sulfonyl)-4-(methyl- d3)benzamide; (*R)-3-((difluoromethyl)sulfonyl)-N-((2-(6-(3-methyl-5-oxopiperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; (*S)-3-((difluoromethyl)sulfonyl)-N-((2-(6-(3-methyl-5-oxopiperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 4-((2,2-difluoroethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropyri din-2 -yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 4-(((difluoromethyl)sulfonyl)methyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)- 4-fluoropyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-((fluoromethyl)sulfonyl)benzamide 3-(difluoromethoxy)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-(3-amino-4,4-dimethyl-2-oxopyrrolidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)-3-(N-methylsulfamoyl)benzamide; N-((2-(2-(4-amino-3 ,3 -difluoropiperidin- 1 -yl)pyrimidin-4-yl)- 1 ,6-naphthy ridin- 7-yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)- 1 ,6-naphthyri din-7 -yl)methyl)-4-methylbenzamide; tert-butyl 3-((5-(7-((3-((difluoromethyl)sulfonyl)benzamido)methyl)-l,6- naphthy ridin-2-y l)py ridin-2-y l)oxy )azetidine- 1 -carboxylate N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l, 6-naphthyridin- 7-yl)methyl)-3-((2-hydroxyethyl-2,2-d2)sulfonyl)-4-methylbenzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-3,5-dimethylpiperazin-l-yl)pyridin- 2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 4-amino-N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin-4-yl)-l,6- naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-((cis)-2,6-dimethylmorpholino)-6-oxo- l,6-dihydropyrimidin-4-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; (*S)-3-((difluoromethyl)sulfonyl)-N-((2-(6-(3-(trifluoromethyl)piperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; (*R)-3-((difluoromethyl)sulfonyl)-N-((2-(6-(3-(trifluoromethyl)piperazin-l- yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)-5 -fluorobenzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((2,2,6,6-tetramethylpiperidin-4- yl)oxy)pyridin-3-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((2,2,6,6-tetramethyltetrahydro-2H-pyran- 4-yl)oxy)pyridin-3-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-(S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((2,2,6,6-tetramethyltetrahydro- 2H-pyran-4-y l)oxy)pyri din-3 -yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-3,5-dimethylpiperazin- l-yl)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((3R,5S)-3,5- dimethylpiperazin-l-yl)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)benzamide N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyridin- 7-yl)methyl)-4-((methylsulfonyl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-3-((methylsulfonyl)methyl)benzamide; 3-chloro-5-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyri din- 7 -yl)methyl)benzamide; (*R)-N-((2-(6-(3,3-difluoro-4-hydroxypiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; (*S)-N-((2-(6-(3,3-difluoro-4-hydroxypiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; (*S)-4-methyl-N-((2-(6-(3-methyl-3-morpholinopyrrolidin-l-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide (*R)-4-methyl-N-((2-(6-(3-methyl-3-morpholinopyrrolidin-l-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-3-(methylsulfonyl)benzamide 3-((difluoromethyl)sulfonyl)-N-((2-(6-((2-oxo-l,3-oxazinan-5-yl)oxy)pyridin-3- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(oxetan-3-yloxy)pyridin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; 3-chloro-N-((2-(3,4-dimethyl-6-(4,7-diazaspiro[2.5]octan-7-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 4-((cyanomethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-4-((2,2,2-trifluoroethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyri din-2 -yl)-l,6-naphthyri din- 7-yl)methyl)-4-((2-hydroxyethyl)sulfonyl)benzamide N-((2-(6-(azetidin-3-yloxy)-5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)methyl)- 3-((difluoromethyl)sulfonyl)benzamide; 3-(2,2-difluoroethoxy)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin- 2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((lR,5S,6r)-6-hydroxy-3- azabicyclo[3.1. l]heptan-3-yl)pyri din-2 -yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(4,4-dimethyl-2-oxoimidazolidin-l- yl)pyrimidin-4-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((2,2,6,6-tetramethyltetrahydro-2H-pyran- 4-yl)oxy)pyridazin-3-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2,2,2-trifluoroethyl)sulfonyl)benzamide 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((S)-3-methyl-5- oxopiperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyridin-7 -yl)methyl)benzamide; 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((S)-3-methyl-5- oxopiperazin- 1 -yl)pyridin-2-yl)- 1 ,6-naphthyridin-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(3-(dimethylamino)-2-oxopyridin-l(2H)-yl)- l,6-naphthyridin-7-yl)methyl)benzamide; 3-(difluoromethoxy)-5-((difluoromethyl)sulfonyl)-N-((2-(2-((cis)-2,6- dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; (*S)-N-((2-(2-(4-amino-3,3-difluoropiperidin-l-yl)pyrimidin-4-yl)-l,6- naphthyridin-7-yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; (*R)-N-((2-(2-(4-amino-3,3-difluoropiperidin-l-yl)pyrimidin-4-yl)-l,6- naphthyridin-7-yl)methyl)-3-fluoro-5-(methylsulfonyl)benzamide; 3-((*R)-azetidine-l-sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyri din-2 -yl)-l,6-naphthyri din-7-yl)methyl)-4- methylbenzamide; 3-((*S)-azetidine-l-sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4- methylbenzamide; 3-((cyanomethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-(3-(2-hydroxyethyl)oxetan-3-yl)-4-methylbenzamide; 3-(S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyridin-7 -yl)methyl)benzamide; 3-fluoro-N-((2-(6-(2-hydroxy-2-methyl-7-azaspiro[3.5]nonan-7-yl)pyridin-2-yl)- l,6-naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6-hydroxy-6-(trifluoromethyl)-2- azaspiro[3.3]heptan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(2-hydroxy-2-methyl-7- azaspiro[3.5]nonan-7-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(2-hydroxy-2-methyl-7- azaspiro[3.5]nonan-7-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-(6-hydroxy-6-(trifluoromethyl)-2- azaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6-hydroxy-6-methyl-2- azaspiro[3.3]heptan-2-yl)pyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(3-(difluoromethyl)-6,7-dihydropyrazolo[l,5-a]pyrazin-5(4H)-yl)-l,6- naphthyridin-7-yl)methyl)-3-((difluoromethyl)sulfonyl)benzamide; 3-(difluoromethoxy)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-(methylsulfonyl)benzamide; (*S)-4-methyl-3-(methylsulfonyl)-N-((2-(l-(pyridin-4-yl)piperidin-3-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-5-iodopyridin-2-yl)-l,6-naphthyridin- 7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(3-(difluoromethyl)-6,7-dihydropyrazolo[l,5-a]pyrazin-5(4H)-yl)-l,6- naphthyridin-7-yl)methyl)-3-(S-(difluoromethyl)sulfonimidoyl)benzamide; 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(2-((cis)-2,6- dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; N-((2-(6-(6-(difluoromethyl)-6-hydroxy-2-azaspiro[3.3]heptan-2-yl)pyridin-2- yl)- 1 ,6-naphthyri din-7 -y I )methyl )-3-((di H uoromethy I )sul fonyl )benzami de; 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(2-((cis)-2,6- dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin- 4-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-chloro-5-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-chloro-5-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; N-((2-(6-fluoropyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-4-methyl-3- (methylsulfonyl)benzamide; and 3-((difluoromethyl)sulfonyl)-N-((2-(6-fluoropyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)benzamide; and pharmaceutically acceptable salts, stereoisomers, and isotopic variants thereof.
12. 12. A compound of claim 1, selected from the group consisting of: N-((2-(6-((cis)-2,6-dimethylmorpholino)pyri din-2 -yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3- ((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methyl-3-(methylsulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)-3- ((2-hydroxy ethyl)sulfonyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyridin-7- yl)methyl)-3-((2-hydroxyethyl)sulfonyl)benzamide; N-((2-(6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-4-methylbenzamide; N-((2-(4-fluoro-6-(4,7 -di azaspiro [2.5] octan-7-yl)pyridin-2-yl)- 1 ,6-naphthyridin-7- yl)methyl)-4-(2-hydroxyethyl)-3-(methylsulfonyl)benzamide; N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-3-((2-hydroxyethyl)sulfonyl)-5-methylbenzamide; N-((2-(2-((cis)-2,6-dimethylmorpholino)pyrimidin-4-yl)-l,6-naphthyridin-7-yl)methyl)-4- methyl-3-(methylsulfonyl)benzamide; 3-fluoro-N-((2-(4-fluoro-6-((3a,4p,5a)-4-hydroxy-3,5-dimethylpiperidin-l-yl)pyri din-2- yl)-l,6-naphthyridin-7-yl)methyl)-5-((2-hydroxyethyl)sulfonyl)benzamide; 3-chloro-5-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)-4-fluoropyri din-2 -yl)- 1 ,6-naphthyri din- 7 -yl)methyl)benzamide; 3-chloro-5-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((2R,6S)-2,6- dimethylmorpholino)-4-fluoropyri din-2 -yl)- 1 ,6-naphthyri din- 7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)benzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-3-((*S)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; N-((2-(6-((cis)-2,6-dimethylmorpholino)-4-fluoropyridin-2-yl)-l,6-naphthyri din-7- yl)methyl)-3-((*R)-2-hydroxyethylsulfonimidoyl)-4-methylbenzamide; 3-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropy ridin-2-y 1)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)-4- fluoropy ridin-2-y 1)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-4-methylbenzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2-yl)-l,6- naphthyridin-7-yl)methyl)-5-fluorobenzamide; 3-chloro-5-((difluoromethyl)sulfonyl)-N-((2-(6-((cis)-2,6-dimethylmorpholino)pyridin-2- yl)-l,6-naphthyridin-7-yl)methyl)benzamide; 3-((difluoromethyl)sulfonyl)-N-((2-(6-(6-hydroxy-6-methyl-2-azaspiro[3.3]heptan-2- yl)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; 3-chloro-5-((*R)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)-l,6-naphthyridin-7-yl)methyl)benzamide; and 3-chloro-5-((*S)-S-(difluoromethyl)sulfonimidoyl)-N-((2-(6-((cis)-2,6- dimethylmorpholino)pyridin-2-yl)- 1 ,6-naphthyri din-7 -yl)methyl)benzamide; and pharmaceutically acceptable salts, isotopic variants, and stereoisomers thereof.
13. 13. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of any one of the preceding claims; and at least one pharmaceutically acceptable excipient.
14. 14. A compound according to any one of claims 1 to 12 for use in therapy.
15. 15. A compound according to any one of claims 1 to 12 for use in the treatment of a SMARCA4 deficient cancer.
16. 16. The compound for the use of claim 15, wherein the SMARCA4 deficient cancer is SMARCA4 deficient non-small cell lung cancer (NSCLC).
17. 17. A compound according to any one of claims 1 to 12 for use in the treatment of a disease state or condition mediated by the SMARCA2 protein.
18. 18. The compound for the use of claim 17, wherein the disease state or condition mediated by the SMARCA2 protein is cancer or non-small-cell lung carcinoma (NSCLC).
19. 19. Use of a compound as defined in any one of claims 1 to 12 for the manufacture of a medicament for the treatment of cancer or NSCLC.
20. 20. An in vitro method of modulating SMARCA2 activity comprising contacting the SMARCA2 protein, or portion thereof, with a compound, or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 12.

Description

1 ,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS FIELD OF THE INVENTION [0001] The invention relates to pharmaceutical compounds and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of the SMARCA2 protein and to their use in the treatment of SMARCA4 deficient cancers, e.g., SMARCA4 deficient non-small cell lung cancer (NSCLC). BACKGROUND OF THE INVENTION [0002] The Switch/Sucrose Non-Fermentable (SWI/SNF), also known as BAF complex, is a multi-subunit complex that modulates chromatic structure through the activity of two mutually exclusive helicase/ ATPase catalytic subunits: SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2, BRAHMA or BRM) and SWI/ SNF-Related, Matrix- Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4 or BRG1). The core and the regulatory subunits couple ATP hydrolysis to the perturbation of histone-DNA contacts, thereby providing access points to transcription factors and cognate DNA elements that facilitate gene activation and repression. [0003] Mutations in the genes encoding the twenty canonical SWI/SNF subunits are observed in nearly 20% of all cancers with the highest frequency of mutations observed in rhabdoid tumors, female cancers (including ovarian, uterine, cervical and endometrial), lung adenocarcinoma, gastric adenocarcinoma, melanoma, esophageal, and renal clear cell carcinoma. Despite having a high degree of homology, and their presumed overlapping functions, SMARCA2 and SMARCA4 have been reported as having different roles in cancer. For example, SMARCA4 is frequently mutated in primary tumors, while SMARCA2 inactivation is infrequent in tumor development. In fact, numerous types of cancer have been shown to be SMARCA4-related (e.g., cancers having a SMARCA4-mutation or a SMARCA4-deficiency, such as lack of expression), including, e.g., lung cancer (such as non- small cell lung cancer or NSCLC). [0004] SMARCA2 has been demonstrated as one of the top essential genes in SMARCA4- related or -mutant cancer cell lines. This is because SMARCA4-deficient patient populations or cells depend exclusively on SMARCA2 activity - i.e., there is a greater incorporation of SMARCA2 into the complex to compensate for the SMARCA4 deficiency. Thus, SMARCA2 may be targeted in SMARCA4-related/deficient cancers. The co-occurrence of the deficiency of the expression of two (or more) genes that leads to cell death is known as synthetic lethality. Accordingly, synthetic lethality can be leveraged in the treatment of certain SMARCA2/SMARCA4-related cancers. [0005] There is an ongoing need for effective treatment for diseases that are treatable by inhibiting or degrading SMARCA2 (i.e., BRAHMA or BRM). However, non-specific effects, and the inability to selectively target and modulate SMARCA2 remains an obstacle to the development of effective treatments. As such, small-molecule therapeutic agents that target SMARCA2 would be very useful. [0006] An objective of the present invention is to provide compounds that are selective on SMARCA2 over SMARCA 4. [0007] An objective of the present invention is to provide SMARCA2 inhibitors that are effective in the treatment of SMARCA4 deficient cancers. [0008] An objective of the present invention is to provide compounds SMARCA2 inhibitors that are effective in the treatment of SMARCA4 deficient NSCLC. SUMMARY OF THE INVENTION [0009] Embodiments of the present invention relate to certain uses and methods of use of 1,6- naphthyridine chemical entities having SMARCA2 modulating properties, and pharmaceutical compositions comprising these chemical entities, to the use of said chemical entities as inhibitors of the SMARCA2 protein, and to methods of treatment or use in the treatment of SMARCA4 deficient cancers, as described in the claims. [0010] Additional embodiments, features, and advantages of the invention will be apparent from the following detailed description and through practice of the invention. [0011] Embodiments of this invention are uses and methods of treatment using compounds of Formula (I), Wherein R1 is an optionally substituted phenyl selected from: (a) 2-chlorophenyl, 2-methyl-5-(lH-tetrazol-l-yl)phenyl, 5-(tert-butyl)-2- methoxyphenyl, 3-fluoro-2-(lH-l,2,3-triazol-l-yl)phenyl, 2-fluoro-5-(l- hydroxyethyl)-4-methylphenyl, wherein Ra is selected from: H; halo; C1-4alkyl; C1-4alkyl substituted with one or two members each independently selected from OH, cyclopropyl, CN, and CH2CO2C1-4alkyl; C1-4haloalkyl; C1-4haloalkyl substituted with one or two OH members; CN; OC1-4alkyl; OC1-4haloalkyl; (P=O)(CH3)2; CO2C1-4alkyl; NH(SO2-C2-3alkenyl), and NH(C=O)C2-3alkynyl; Rb is selected from: Cl, F, Br, C1-4alkyl, OC1-4alkyl, cyclopropyl, and 4-methyl-lH- imidazol-l-yl; Rc is selected from: Cl, Br, I, C1-4alky