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EP-4740734-A1 - TREATMENT OF MITE INFESTATION

EP4740734A1EP 4740734 A1EP4740734 A1EP 4740734A1EP-4740734-A1

Abstract

The invention relates to bisabolol for use as a miticide agent, the use of bisabolol as a miticide, a method for reducing or preventing an infestation of an animal by a mite, comprising exposing the mite to bisabolol, a composition adapted for use as a miticide agent comprising bisabolol, a strip adapted for use in apiculture comprising bisabolol and to a hive comprising bisabolol.

Inventors

  • PADE, Rémi
  • POUGNAS, JEAN-LUC

Assignees

  • Veto-Pharma

Dates

Publication Date
20260513
Application Date
20241108

Claims (14)

  1. Bisabolol or a stereoisomer thereof for use as a miticide agent.
  2. The compound for use according to claim 1, wherein the bisabolol or stereoisomer thereof is selected from the group consisting of a compound of Formula (I), bisabolol oxide A, CAS Registry Number 22567-36-8, and bisabolol oxide B, CAS Registry Number 55399-12-7, (R1, R2) represents (H, OH) or (OH, H).
  3. The compound for use according to any of the preceding claims, wherein the bisabolol or stereoisomer thereof is a compound selected from the group comprising: - α-bisabolol; - (R,R)-α-bisabolol; - (+)-(αR,1R)-α-bisabolol; - (-)-(αS,1S)-α-bisabolol; - (R,S)-α-bisabolol; - (+)-(αS,1R)-α-bisabolol; - (-)-(αR,1S)-α-bisabolol; - β-bisabolol; - (R,R)-β-bisabolol; - (1R,βR)-β-bisabolol; - (1S,βS)-β-bisabolol; - (R,S)-β-bisabolol; - (1R,βS)-β-bisabolol; - (1S,βR)-β-bisabolol; - Bisabolol oxide A; and - Bisabolol oxide B.
  4. The compound for use according to any of the preceding claims, wherein the bisabolol is α-bisabolol.
  5. The compound for use according to any of the preceding claims, wherein the bisabolol is bisabolol oxide A.
  6. The compound for use according to claim 1, for reducing or preventing a mite infestation in an animal such as a bee.
  7. The compound for use according to any of the preceding claims, wherein the mite is (i) varroa mite, such as varroa destructor, or (ii) Tropilaelaps spp., such as Tropilaelaps clareae.
  8. Use of bisabolol or a stereoisomer thereof, as defined in any of claims 1 to 7, as a miticide agent.
  9. Use according to claim 8, for reducing or preventing a mite infestation in an animal, such as a bee.
  10. Method for reducing or preventing a mite infestation in an animal, such as a bee, comprising exposing the animal to bisabolol or a stereoisomer thereof, as defined in any of claims 1 to 7.
  11. Use or method according to any of claims 8 to 10, wherein the mite is (i) varroa mite, such as varroa destructor, or (ii) Tropilaelaps spp., such as Tropilaelaps clareae or Tropilaelaps mercedesae.
  12. Composition adapted for use as a miticide agent, said composition comprising (i) bisabolol or a stereoisomer thereof, as defined in any of claims 1 to 7, (ii) one or more attractant(s) for bees, and eventually (iii) one or more polymer(s) selected from the group consisting in a plastic material, a rubber, an adhesive, a resin and polyholoside fibers.
  13. Strip adapted for use in apiculture, comprising (i) bisabolol or a stereoisomer thereof, as defined in any of claims 1 to 7, or (ii) a composition according to claim 12.
  14. Beehive comprising (i) bisabolol or a stereoisomer thereof as defined in any of claims 1 to 7, (ii) a composition according to claim 12, and/or (iii) a strip according to claim 13.

Description

Technical field The invention relates to bisabolol for use as a miticide agent, the use of bisabolol as a miticide, a method for reducing or preventing an infestation of an animal by a mite, comprising exposing the mite to bisabolol, a composition adapted for use as a miticide agent comprising bisabolol, a strip adapted for use in apiculture comprising bisabolol and to a hive comprising bisabolol. Prior art Most animals can be infested with mites. This is the case for example of domestic animals such as dogs, cats, horses but also farm animals such as bees, cattle, sheep, poultry. Beyond the inconvenience caused to animals, mites can weaken the animal, transmit diseases or even cause the death of the animal. Colony Collapse Disorder (CCD) is the name given to the phenomenon of abnormal and recurrent mortality observed since the 1990s in honeybee colonies around the world. Several explanations for this phenomenon have already been put forward, in particular the increase in parasitic diseases, and more particularly those caused by varroa and varroosis mites. This mite parasitizes bees and weakens colonies by reducing their immune defenses and their physiological state and can be a vector of viruses. The treatment of this parasite is a major issue for the survival of colonies and therefore the maintenance of pollination as well as the conservation of their productivity. Today, everyone is aware of the impact of varroa mites on colonies. Many techniques are used to determine colony infestation. They are based in particular on the calculation of the percentage of bee infestation by removing the varroa mites attached to bees (percentage of phoretic varroa mites per 100 bees) using a detergent, a liquid comprising alcohol, CO2 or icing sugar then counting the detached varroa mites [1]. Several more or less sophisticated devices have been described in the literature for removing varroa mites from bees, in particular the device described in Canadian patent application n°2,943,917 or the device described in Community model n°003419415-0001. The percentage of infestation corresponds to the number of varroa mites found on 100 adult bees. Depending on the time of year, it is possible to generate indicators: Between 0 and 2% infestation, the colony is doing well.At about 5% infestation, there is an effect on population dynamics and on honey production (about 25% less harvest during a honey flow, [2]).At about 10% or more infestation, the colony will die more or less quickly and will not survive the winter. For the colonies to have a maximum of 5% infestation at the end of the season, it is very important that the infestation in the spring be less than 1%. Despite the research and experimentation efforts carried out for more than thirty years, the current therapeutic offer available to fight against this mite is reduced to a few products and beekeepers feel helpless in the face of this scourge. However, the latter have some treatments to intervene to protect their colonies, but few compounds are really authorized to treat varroosis. In France, there are to date only 6 active compounds for use against varroa with variable efficiency. The treatments are currently divided into two categories: chemical and biological compounds, but they are also differentiated by their duration of treatment (long or short). Long treatments are generally done at the end of the apiculture season (mid-August) before the fatal varroa mite peak in August/September and can also be applied in spring in addition to limit summer infestation as much as possible. Short treatments must be carried out in the absence of brood (outside the summer season) and are used in addition to a long treatment to increase the efficiency of the latter. There are three chemical compounds derived from synthetic molecules: amitraz, tau-fluvalinate and flumethrin. There are three natural compounds used in organic apiculture: thymol, oxalic acid and formic acid. Among them, some unfortunately see their efficiency decrease because of the increasing resistance of varroa mites to certain compounds used. This is particularly the case for the tau-fluvalinate and flumethrin compounds. In addition, the reduced number of treatments available does not allow enough alternatives in the context of effective health management. These compounds have also shown their efficiency in treating infestations by mites in animals other than bees. Research is therefore still necessary to identify new molecules, such as molecules that can be used in organic apiculture, that are effective against mites and without risk for the treated animals and for humans, in particular for combating varroa mites and without risk both for bee colonies and for the environment and the beekeeper, without degrading the quality of the honey for human consumption. Summary of the invention According to a first aspect, the invention relates to bisabolol or a stereoisomer thereof for use as a miticide agent. In some embodime