EP-4740753-A1 - INTESTINAL REGULATOR

Abstract

The present invention provides an intestinal regulating agent containing a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms.

Inventors

• KITAO, Kohey

Assignees

• Noster Inc.

Dates

Publication Date

20260513

Application Date

20240705

Claims (7)

1. An intestinal regulating agent comprising a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms.
2. The intestinal regulating agent according to claim 1, wherein the hydroxy fatty acid has a hydroxyl group at positions 10, 11, 12, 13, 14, and/or 15, and the oxo fatty acid has a carbonyl group at positions 10, 11, 12, 13, 14, and/or 15.
3. The intestinal regulating agent according to claim 1, wherein the hydroxy fatty acid or the oxo fatty acid is a saturated fatty acid, or an unsaturated fatty acid having one to five double bonds.
4. The intestinal regulating agent according to claim 1, wherein the hydroxy fatty acid is 10-hydroxy-cis-12-octadecenoic acid.
5. The intestinal regulating agent according to any one of claims 1 to 4, wherein the intestinal regulating agent is a food product or a food additive.
6. The intestinal regulating agent according to any one of claims 1 to 4, wherein the intestinal regulating agent is a medicament or a quasi-drug.
7. The intestinal regulating agent according to any one of claims 1 to 4, wherein the intestinal regulating agent is feed or feed additive.

Description

Technical Field The present invention relates to an intestinal regulating agent. Background Art In recent years, various lifestyle diseases have become a problem due to changes in dietary habits, unbalanced diets, stress, and the like. One of these diseases is intestinal discomfort, such as constipation and diarrhea. Constipation occurs, for example, when stool remains in the intestines for a long time. Severe constipation can lead to an increase in harmful bacteria in the intestines, an increase in absorption of toxic substances and the like, and can potentially be a contributing factor to colorectal cancer. Therefore, the development of intestinal regulating agents using, as an active ingredient, a substance having an intestinal regulating effect for improving intestinal discomfort is underway. In addition, it has been reported that some of hydroxy fatty acids and oxo fatty acids possess activity for improving lifestyle diseases, such as improving lipid metabolism (Patent Literature 1, and Non-Patent Literatures 1 and 2), and therefore, attention is now focusing on the physiological functions of hydroxy fatty acids and oxo fatty acids. Citation List Patent Literature Patent Literature 1: Japanese Patent Laid-Open No. 2011-184411 Non-Patent Literature Non-Patent Literature 1: Kim Y-I,(2011), Mol. Nutr. Food Res., vol.55, p.585-593Non-Patent Literature 2: Kim Y-I,(2012), PLoS ONE, vol.7, no.2, e31317 Summary of Invention Technical Problem However, it has not been previously known that a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms possess an intestinal regulating effect. Therefore, an object of the present invention is to provide an intestinal regulating agent containing a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms. Solution to Problem As a result of earnest studies, the present inventors have discovered that a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms possess an intestinal regulating effect, and thus, the present invention has been accomplished. Specifically, the present invention provides the following. [1] An intestinal regulating agent containing a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms.[2] The intestinal regulating agent according to [1], wherein the hydroxy fatty acid has a hydroxyl group at positions 10, 11, 12, 13, 14, and/or 15, and the oxo fatty acid has a carbonyl group at positions 10, 11, 12, 13, 14, and/or 15.[3] The intestinal regulating agent according to [1] or [2], wherein the hydroxy fatty acid or the oxo fatty acid is a saturated fatty acid, or an unsaturated fatty acid having one to five double bonds.[4] The intestinal regulating agent according to any one of [1] to [3], wherein the hydroxy fatty acid is 10-hydroxy-cis-12-octadecenoic acid.[5] The intestinal regulating agent according to any one of [1] to [4], wherein the intestinal regulating agent is a food product or a food additive.[6] The intestinal regulating agent according to any one of [1] to [4], wherein the intestinal regulating agent is a medicament or a quasi-drug.[7] The intestinal regulating agent according to any one of [1] to [4], wherein the intestinal regulating agent is feed or feed additive.[8] The intestinal regulating agent according to any one of [1] to [4] for use for improving an intestinal environment. The present invention also encompasses the following aspects. [A1] A method for regulating an intestinal environment, comprising administering a physiologically effective amount of a hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms to a subject in need thereof.[A2] The method according to [A1], wherein the hydroxy fatty acid has a hydroxyl group at positions 10, 11, 12, 13, 14, and/or 15, and the oxo fatty acid has a carbonyl group at positions 10, 11, 12, 13, 14, and/or 15.[A3] The method according to [A1] or [A2], wherein the hydroxy fatty acid or the oxo fatty acid is a saturated fatty acid, or an unsaturated fatty acid having 1 to 5 double bonds.[A4] The method according to any one of [A1] to [A3], wherein the hydroxy fatty acid is 10-hydroxy-cis-12-octadecenoic acid. In the methods of [A1] to [A4], the intestinal regulating agent according to any one of [1] to [8] may be administered, or a composition according to any one of [E1] to [E7] described below may be administered. [B1] A hydroxy fatty acid and/or an oxo fatty acid having 14 to 22 carbon atoms for use in a method for regulating an intestinal environment.[B2] The fatty acid according to [B1], wherein the hydroxy fatty acid has a hydroxyl group at positions 10, 11, 12, 13, 14, and/or 15, and the oxo fatty acid has a carbonyl group at positions 10, 11, 12, 13, 14, and/or 15.[B3] The fatty acid according to [B1] or [B2], wherein the hydroxy fatty acid or the oxo fatty acid is a saturated fatty acid, or an unsaturated fatty acid having 1 to 5 double bonds.[B4] The fatty acid according to any one of [B1] to [B