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EP-4740934-A1 - MOISTURIZING AND SCALP MICROBIOME-RESTORING COMPLEX WITH A COMBINATION OF SUGAR DERIVATIVES: LACTOBIONIC ACID, TREHALOSE, AND RHAMNOSE

EP4740934A1EP 4740934 A1EP4740934 A1EP 4740934A1EP-4740934-A1

Abstract

The invention relates to a hair care and/or scalp care composition comprising rhamnose, trehalose and lactobionic acid. Said composition moisturizes the scalp, protects the scalp from dehydration, promotes the growth of Staphylococcus epidermis and/or Cutibacterium acnes on the scalp and can be used for treating or preventing dandruff.

Inventors

  • BELOUS, Elena
  • IVANOVA, Angelina

Assignees

  • SkyLab AG

Dates

Publication Date
20260513
Application Date
20241107

Claims (15)

  1. A hair care and/or scalp care composition, said composition comprising the following components: a) rhamnose, b) trehalose and c) lactobionic acid.
  2. The composition of claim 1, wherein said composition has a pH in the range of 4.0 - 9.0, preferably in the range of 5-6, further preferably 5.5-5.7.
  3. The composition of claim 1 or claim 2, wherein each of said components is present in said composition in an amount of at least 0.01 % by weight of said composition, preferably 0.02% by weight of said composition, further preferably 0.05% by weight of said composition, further preferably 0.10% by weight of said composition.
  4. The composition of claim 1 or claim 2, wherein each of said three components is present in said composition in an amount of a range selected from the following: 0.01-10.00% by weight, 0.01-5.00% by weight, 0.01-3.00% by weight, 0.01-1.00% by weight, 0.01-0.75 % by weight, 0.01-0.50% by weight, 0.02-10.00% by weight, 0.02-5.00% by weight, 0.02-3.00% by weight, 0.02-1.00% by weight, 0.02-0.75 % by weight, 0.02-0.50% by weight, 0.05-10.00% by weight, 0.05-5.00% by weight, 0.05-3.00% by weight, 0.05-1.00% by weight, 0.05-0.75% by weight, 0.05-0.50% by weight, 0.10-10.00% by weight, 0.10-5.00% by weight, 0.10-3.00% by weight, 0.10-1.00% by weight, 0.10-0.75% by weight, 0.10-0.50% by weight.
  5. The composition of claim 1 or claim 2, wherein said composition comprises by weight of said composition one of the following: i) 0.6% rhamnose, 1.5% trehalose, 1.5% lactobionic acid; ii) 0.1% rhamnose, 0.1 % trehalose, 0.1% lactobionic acid; iii) 0.2% rhamnose, 0.5% trehalose, 0.5% lactobionic acid.
  6. The composition of any of the preceding claims, wherein said composition is formulated for application on a subject's hair and/or scalp.
  7. The composition of claim 6, wherein said composition is a formulation selected from the following: liquid, aerosol, suspension, solution, tincture, cream, paste, lotion, ointment, gel, balsam, foam, shampoo and conditioner.
  8. Use of the composition of any of claims 1-7 for moisturizing the scalp of a living subject, wherein said subject is preferably a human or an animal.
  9. The composition of any of claims 1-7 for use as a medicament.
  10. The composition of any of claims 1-7 for promoting health of a scalp or for treating or preventing a scalp disorder of a living subject, wherein said subject is preferably a human or an animal.
  11. The composition of any of claims 1-7 for treating or preventing dandruff on the scalp of a living subject, wherein preferably said dandruff is caused by fungi of the Malassezia species and/or said subject is a human or an animal.
  12. The composition for use of any of claims 1-7 for promoting growth of Staphylococcus epidermis and/or Cutibacterium acnes on the scalp of a living subject, wherein said subject is preferably a human or an animal.
  13. A method of moisturizing a scalp of a living subject or a method for protecting a scalp of a living subject from dehydration, wherein said subject is preferably a human or an animal, said method comprising treating said scalp with a composition of any of claims 1-7.
  14. The method of claim 13, wherein said treatment comprises treating said scalp in a leave-on manner with said composition.
  15. The use of rhamnose. trehalose and lactobionic acid in the manufacture of composition of any of claims 1-7.

Description

FIELD OF THE INVENTION The present invention relates to novel applications of 6-deoxymannose - rhamnose, α-D-glucopyranosyl-(1 → 1)-α-D-glucopyranoside - trehalose, 4-O-β-galactopyranosyl-D-gluconic acid - lactobionic acid as a medium for promoting scalp moisturization and restoring the commensal microbiome of the scalp. It can be used in the field of hair care products. Rhamnose, trehalose and lactobionic acid are stable and fully suitable for utilization in cosmetic and pharmaceutical formulations. BACKGROUND ART The scalp surface represents a specific microenvironment for microorganisms, which is subject to physiologic conditions of the host organism, including cutaneous grease content, humidity and pH. Microbial communities ensure survival on the surface of the host organism, such as the skin, through various regulatory processes, including biofilm formation and quorum definition. Thus, it is expected that metabolic processes between the scalp surface and the microbiome normally support the growth of microbial biofilms in symbiotic, commensal or pathogenic form [1]. Usage of high-throughput sequencing of new generation and robust computational analysis in recent years has led to an in-depth understanding of the scalp microbiome, providing new information regarding the pathophysiology of scalp-related diseases such as dandruff and seborrheic dermatitis. Global investigations have demonstrated that the scalp microbiome is characterized by a rather low bacterial diversity compared to other body areas and is dominated by Cutibacterium acnes (formerly Propionibacterium acnes), Staphylococcus epidermidis and Malassezia spp. S. epidermidis and C. acnes represent a part of the commensal microbiota and as have been reported make positive impact upon the skin by modulating the immune response and protecting against pathogens. In the investigation [2], the authors conducted a metagenomic analysis of the scalp microflora of an Indian population and have found that healthy scalp compared to scalp covered with dandruff showed an increased content of bacterial pathways associated with the synthesis and metabolism of amino acids, biotin and group B vitamins. This indicated a new potential role for bacterial commensals in maintaining nutrient homeostasis in the scalp: they protect the skin from colonization by pathogens, stimulate production of the complement system and cytokines involved in the initiation and maintenance of the immune response. In addition to this, microbiota helps to reduce inflammation and promotes tissue repair [3]. Since changes in skin physiology are thought to play an important role in shaping the skin microbiome, scalp physiologic parameters such as sebum levels, sunlight exposure, temperature, air humidity, transepidermal moisture loss (TEWL) and hydration levels become particularly important [1,3]. The prevalence of commensal microorganisms on the scalp helps reduce the risk of dandruff, due to the predominance of the fungus Malassezia spp. As a result, for the formation of such microbiome, it is important to observe favorable environmental conditions for them, which include the degree of the scalp moisturization. Propionibacterium spp lysates have been used as agents to promote scalp moisturization and resulting growth of a commensal scalp microbiome. The lysates can absorb free radicals, preventing damage to cells by free oxygen radicals, thereby reducing inflammation. Due to this, they are used in various anti-inflammatory products [4]. The patent WO2014053625A2 examines the potential of Propionibacteriumfreudenreichii lysate to treat and/or prevent scalp diseases by affecting hydration, namely scalp moisturization, scalp barrier function, activating defense mechanisms and immune regulation, thereby reducing scalp inflammation and creating a balanced barrier, preserving its integrity and maintaining a balanced microflora. However, regulatory considerations and safety issues related to usage of the microbiome in skin care products require focused attention. While oral probiotics have a clear legal definition related to bacteria and yeast, the absence of such a definition for skin probiotics underlines regulatory gaps indicating an urgent need for guidance in this rapidly developing field. Further research is also needed to understand their long-term effects [5]. Various sugars are used as alternative agents that can be used to moisturize the skin. The first example relates to use in oral care and skin care products. Xylitol is a natural alcohol sugar that is known for its effectiveness in reducing caries formation in the oral cavity and it possesses moisturizing properties. The authors of the investigation [6] paid attention to the fact that usage of xylitol (100 mM) during 2 hours improves lipid fluidity in the uppermost layer of the stratum granulosum. Seven volunteers with dry skin showed a 20% reduction in moisture loss when treated with xylitol during 10 minutes compared to water. The e