EP-4740936-A1 - HYDROGEL FOR BODY CAVITY INJURY TREATMENT AND BODY CAVITY INJURY TREATMENT KIT

EP4740936A1EP 4740936 A1EP4740936 A1EP 4740936A1EP-4740936-A1

Abstract

A hydrogel for treatment of body cavity injury is derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation. The hydrogel for treatment of body cavity injury has a granular shape. The hydrogel is injected into a body cavity using an injection device, and used for wound treatment of the body cavity. A kit for treatment of body cavity injury includes: an injection device; a tube to be connected to the injection device; and a hydrogel for treatment of body cavity injury, filled in the injection device and having a granular shape; wherein the hydrogel for treatment of body cavity injury is derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation.

Inventors

TAKEI TAKAYUKI
YOSHIDA MASAHIRO
YAMASHITA YUSUKE
HOSOYA KEI

Assignees

Kagoshima University
iCUREX Co., Ltd.

Dates

Publication Date: 20260513
Application Date: 20240807

Claims (6)

A hydrogel for treatment of body cavity injury, the hydrogel being derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation, wherein the hydrogel for treatment of body cavity injury has a granular shape, is injected into a body cavity by an injection device, and is used for wound treatment of the body cavity.
The hydrogel for treatment of body cavity injury according to claim 1, having a particle size of not more than 2 mm.
The hydrogel for treatment of body cavity injury according to claim 1, wherein the aldonic acid is gluconic acid.
The hydrogel for treatment of body cavity injury according to any one of claims 1 to 3, wherein the body cavity is a nasal cavity.
A kit for treatment of body cavity injury, comprising: an injection device; a tube to be connected to the injection device; and a hydrogel for treatment of body cavity injury, filled in the injection device and having a granular shape, wherein the hydrogel for treatment of body cavity injury is derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation.
The kit for treatment of body cavity injury according to claim 5, wherein the tube has a length of 5 to 20 cm.

Description

Technical Field The present disclosure relates to a hydrogel for treatment of body cavity injury, and a kit for treatment of body cavity injury. Background Art A wound dressing is a medical material that covers an injury (a wound) on the body surface to keep the injury in a wet state, to thereby promote curing of the wound. A hydrogel-type wound dressing that contains a large amount of water is suitable for keeping a wound in a wet state. Chitosan has been reported to have a wound-healing effect, and a chitosan hydrogel is suitable as a wound dressing. However, preparation of a hydrogel from chitosan involves use of a highly toxic chemical cross-linking agent, and a chitosan hydrogel obtained by such preparation is not suitable for medical purposes. In view of this, a method of preparing a chitosan-derived hydrogel without using additives harmful to the living body has been proposed (Patent Literature 1). In Patent Literature 1, a hydrogel having no biological toxicity was prepared by freezing and thawing of an aqueous solution containing an aldonic acid-modified chitosan. Further, Patent Literature 2 discloses use of a composition containing a soluble chitosan or derivatized chitosan for application to a wound on a body surface or body cavity. Citation List Patent Literature Patent Literature 1: International Publication No. WO 2012/105685Patent Literature 2: Unexamined Japanese Patent Application Publication (Translation of PCT Application) No. 2013-523827 Summary of Invention Technical Problem Patent Literature 1 is a wound dressing that covers a wound on a body surface, and there is no description at all on application of the wound dressing to a wound of a body cavity. The composition of Patent Literature 2 is in a liquid state, and orally administered to a body cavity such as a paranasal sinus by spraying or the like. Since this composition is in a liquid state and has fluidity, the composition flows away after application to a wound site, and hence cannot be retained on the wound. The present disclosure was made in view of the above problem, and an objective of the disclosure is to provide a hydrogel for treatment of body cavity injury, the hydrogel being also applicable to body cavity injury, and a kit for treatment of body cavity injury. Solution to Problem A hydrogel for treatment of body cavity injury according to a first aspect of the present disclosure is a hydrogel for treatment of body cavity injury derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation, wherein the hydrogel for treatment of body cavity injury has a granular shape, is injected into a body cavity by an injection device, and is used for wound treatment of the body cavity. It is preferable that the hydrogel for treatment of body cavity injury has a particle size of not more than 2 mm. It is preferable that the aldonic acid is gluconic acid. It is preferable that the body cavity is a nasal cavity. A kit for treatment of body cavity injury according to a second aspect of the present disclosure includes: an injection device;a tube to be connected to the injection device; anda hydrogel for treatment of body cavity injury, filled in the injection device and having a granular shape, whereinthe hydrogel for treatment of body cavity injury is derived from a chitosan derivative in which an aldonic acid is bound to an amino group of a glucosamine unit of chitosan by dehydration condensation. It is preferable that the tube has a length of 5 to 20 cm. Advantageous Effects of Invention According to the present disclosure, a hydrogel for treatment of body cavity injury, the hydrogel also being applicable to body cavity injury, and a kit for treatment of body cavity injury can be provided. Brief Description of Drawings FIG. 1 is a diagram illustrating a synthesis scheme for a chitosan derivative;FIG. 2 is a graph illustrating the gluconic acid introduction rate in a chitosan derivative;FIG. 3 is a perspective view of a kit for treatment of body cavity injury;FIG. 4 is a cross-sectional view of a kit for treatment of body cavity injury;FIG. 5 is a photograph of a hydrogel prepared by a freeze-thaw method in Examples;FIG. 6 is a photograph of hydrogels prepared by a high-pressure steam sterilization method in Examples;FIG. 7 is a photograph illustrating a state where a hydrogel for treatment of body cavity injury was filled in an injector and then discharged from a barrel tip;FIG. 8 is a photograph illustrating the state of a paranasal sinus of a patient after endoscopic paranasal sinus surgery;FIG. 9 is a photograph illustrating a state where a hydrogel for treatment of body cavity injury was injected into a paranasal sinus of a patient; andFIG. 10 is a graph illustrating a relationship between plunger displacement and injection force. Description of Embodiments <Hydrogel for Treatment of Body Cavity Injury> The hydrogel for treatment of body cavity inj