Search

EP-4740982-A2 - DRUG DELIVERY DEVICE

EP4740982A2EP 4740982 A2EP4740982 A2EP 4740982A2EP-4740982-A2

Abstract

The invention relates to a drug delivery device (1000), comprising - a housing element (4), - a release member (5) arranged axially moveable with respect to the housing element (4), - a plunger rod (1) arranged axially moveable with respect to the housing element (4), - an energy member (3) configured to provide energy to induce an axial movement of the plunger rod (1) in a distal direction (D), - a displaceable element (41) being displaceable in a radial direction, wherein - the drug delivery device (1000) has a first locked state, wherein in the first locked state - the release member (5) is movable from a distal position in a proximal direction (P) into a proximal position, - the release member (5) is in the distal position and arranged to hold the displaceable element (41) in a first radial position, - the displaceable element (41) held in the first radial position prevents a movement of the plunger rod (1) in distal direction (D) induced by the energy member (3), - the drug delivery device (1000) is configured to be switched from the first locked state into a released state by moving the release member (5) from the distal position into the proximal position, wherein in released state - the release member (5) is in the proximal position and no longer holds the displaceable element (41) in the first radial position, which enables a movement of the displaceable element (41) from the first radial position into a second radial position in order to release the plunger rod (1), - the plunger rod (1), when released, moves in distal direction (D) due to the energy provided by the energy member (3).

Inventors

  • DASBACH, UWE
  • KEMP, THOMAS MARK
  • DENYER, Timothy
  • WILSON, ROBERT
  • ROSIER, Chris

Assignees

  • Sanofi

Dates

Publication Date
20260513
Application Date
20211201

Claims (15)

  1. Drug delivery device (1000), comprising - a housing element (4), - a release member (5) arranged axially moveable with respect to the housing element (4), - a plunger rod (1) arranged axially moveable with respect to the housing element (4), - an energy member (3) configured to provide energy to induce an axial movement of the plunger rod (1) in a distal direction (D), - a displaceable element (41) being displaceable in a radial direction, wherein the drug delivery device (1000) has a pre-released state, wherein, in the pre-released state, the release member (5) is movable from a distal position in a proximal direction (P) into a proximal position, wherein, in the pre-released state, the release member (5) is in the distal position and arranged to hold the displaceable element (41) in a first radial position, and wherein, in the pre-released state, the displaceable element (41) is held in the first radial position and prevents a movement of the plunger rod (1) in distal direction (D) induced by the energy member (3).
  2. The drug delivery device (1000) according to claim 1, wherein the displaceable element (41) is axially and/or rotationally fixed with respect to the housing element (4).
  3. The drug delivery device (1000) according to any one of claims 1 to 2, wherein the displaceable element (41) is pivotally connected to the housing element (4).
  4. The drug delivery device (1000) according to any one of the preceding claims, wherein: the first radial position is a position in which the displaceable element (41) is in its relaxed state, which it would occupy if no external forces would act on the displaceable element (41), or the first radial position is a position in which the displaceable element (41) is biased towards a second radial position.
  5. The drug delivery device (1000) according to any one of the preceding claims, wherein the drug delivery device (1000) comprises a transfer member (2) arranged moveable with respect to the housing element (4), wherein the transfer member (2) and the plunger rod (1) are operatively coupled such that a movement of the transfer member (2) in a first direction is converted into a movement of the plunger rod (1) in distal direction.
  6. The drug delivery device (1000) according to claim 5, wherein the plunger rod (1) and the transfer member (2) are operatively coupled via a threaded interface configured to transform a rotational movement of the transfer member (2) into an axial movement of the plunger rod (1).
  7. The drug delivery device (1000) according to claim 5 or 6, further comprising a first lock element (22), wherein the first lock element (22) is part of the transfer member (2), and wherein in the pre-released state, the first lock element (22) and the displaceable element (41) are engaged with each other.
  8. The drug delivery device (1000) according to claim 7, wherein the energy member (3) is configured to induce a torsion onto the transfer member (2) to force the transfer member (2) to rotate in a first rotational direction, wherein the engagement of the first lock element (22) and the displaceable element (41) prevents the rotation of the transfer member (2) in the first rotational direction induced by the energy member (2).
  9. The drug delivery device (1000) according to claim 7 or 8, wherein the displaceable element (41) comprises a protrusion (410) projecting radially inwardly, and wherein when the displaceable element (41) and the first lock element (22) are engaged, the protrusion (410) projects into a recess (220) of the first lock element.
  10. The drug delivery device (1000) according to claim 9, wherein the protrusion (410) comprises a beveled surface (410a), which essentially runs parallel to a longitudinal axis (A) of extension of the drug delivery device (1000) and which is tilted with respect to a radial direction (R) and with respect to an angular direction (C).
  11. The drug delivery device (1000) according to claim 10, wherein the torque acting on the rotating collar (2) presses a surface of a portion of the transfer member (2) delimiting the recess (220) against the beveled surface (410a) of the protrusion (410) of the resilient arm (41) biasing the resilient arm (41) radially outwardly.
  12. The drug delivery device (1000) according to any one of the claims 5 to 11, wherein the displaceable element (41) is arranged radially between the transfer member (2) and the release member (5).
  13. Drug delivery device (1000) according to any one of the preceding claims, wherein the drug delivery device (1000) is configured to be switched from the pre-released state into a released state by moving the release member (5) from the distal position into the proximal position, wherein in released state - the release member (5) is in the proximal position and no longer holds the displaceable element (41) in the first radial position, which enables a movement of the displaceable element (41) from the first radial position into a second radial position in order to release the plunger rod (1).
  14. Drug delivery device (1000) according to any one of the preceding claims, comprising - a housing (100) with the housing element (4) fixed to or integrated in the housing (100), - a medicament container (8) with a needle (80).
  15. The drug delivery device (1000) according to claim 14 when dependent on claim 5, wherein the transfer member (2) is secured to the housing (100) such that a force necessary for moving the transfer member (2) in one or both axial directions is greater than a force necessary to axially move the plunger rod (1).

Description

Technical field A drug delivery device is provided. Background Administering an injection is a process which presents a number of risks and challenges for users and healthcare professionals, both mental and physical. A drug delivery device may aim to make self-injection easier for patients. A conventional drug delivery device may provide the force for administering the injection by a spring, and trigger button or another mechanism may be used to activate the injection. Drug delivery devices may be single-use or reusable devices. There remains a need for an improved drug delivery device. Summary One object to be achieved is to provide an improved drug delivery device. This object is achieved, inter alia, by the subject-matter of claim 1. Advantageous embodiments and further developments are subject of the dependent claims and are also presented in the following description and the figures. According to at least one embodiment, the drug delivery device comprises a housing element. The housing element may be hollow and/or elongated. The housing element may be a sleeve, e.g. a cylindrically-shaped sleeve. Particularly, the housing element may be a holder for an energy member such as a drive spring, i.e. an element in which an energy member can be stored. The energy member may be secured to the housing element, e.g. by fixing one end of the drive spring to the housing element. According to at least one embodiment, the drug delivery device comprises a release member arranged axially, i.e. in only one or two opposite axial directions, movable with respect to the housing element. The release member may overlap with the housing element along a longitudinal axis of the drug delivery device. The release member may be telescopically coupled to the housing element. The release member may be rotationally fixed to the housing element. According to at least one embodiment, the drug delivery device comprises a plunger rod, arranged axially movable with respect to the housing element. The plunger rod may be hollow or solid. The plunger rod may be cylindrically-shaped, e.g. hollow cylindrically-shaped. In case that the plunger rod is hollow, further elements or members, e.g. other than an energy member for driving the plunger rod, may be received in the plunger rod. Here and in the following, if not stated otherwise, a movement of a member or element or feature is to be understood as a movement with respect to the housing element. The housing element and/or the plunger rod may comprise or consist of plastic. Each of them may be formed in one piece, i.e. be of unitary construction or integrally formed. The housing element and/or the plunger rod may each have a main extension direction parallel to the longitudinal axis. The longitudinal axis may run through one or both of the housing element and the plunger rod, e.g. through the center thereof. According to at least one embodiment, the drug delivery device comprises an energy member configured to provide energy in order to induce an axial movement of the plunger rod in a distal direction, preferably to drive the plunger rod. In other words, the energy member may be configured to provide energy to move the plunger rod in distal direction relative to the housing element. The energy member may be a drive spring, e.g. a torsion drive spring, particularly a spiral torsion spring or clock spring or power spring, or another component configured to induce a movement of the plunger rod, e.g. a gas cartridge or an electric motor. The drive spring may be formed of metal, e.g. steel. The longitudinal axis may run through the center of the drive spring. The plunger rod and/or the energy member may be received in the housing element and may be circumferentially surrounded, e.g. circumferentially completely surrounded, by the housing element. According to at least one embodiment, the drug delivery device comprises a displaceable element being displaceable in a radial direction. The displaceable element may be displaceable between a first radial position and a second radial position. The second radial position may be offset in an outward radial direction with respect to the first radial position. The displaceable element may comprise or consist of plastic. According to at least one embodiment, the drug delivery device has a first locked state. The first locked state is a state which the drug delivery device can occupy and/or into which the drug delivery device can be switched. The energy member may already induce a force onto the plunger rod in the first locked state. For example, the drive spring is already biased in the first locked state. According to at least one embodiment, in the first locked state, the release member is movable from a distal position in a proximal direction into a proximal position. The distal position is also referred to as extended position. The proximal position is also referred to as retracted position. For example, the release member has to be moved in the proximal