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EP-4741020-A1 - NANO PROTECTOR FORMULATION BASED ON HYALURONIC ACID AND AMINO ACIDS FOR SKIN CARE AND REPAIR

EP4741020A1EP 4741020 A1EP4741020 A1EP 4741020A1EP-4741020-A1

Abstract

The present invention relates to a new formulation based on hyaluronic acid and other amino acids that hydrate, repair, brighten, nourish , and protect the skin and defend it topically against all pathogens, but which has a completely different mechanism of action from those disclosed in the prior art. The use, preparation method and dosage forms of the formulation provide a set of cosmetic and medical products that include zinc, TiO2, rosewater, tannins and vitamins to achieve the technical effect stated in the application.

Inventors

  • VAZQUEZ HERNANDEZ, Victor Elías
  • VAZQUEZ HERNANDEZ, Patricia Guadalupe

Assignees

  • Bionano Research, S.A. De C.V.

Dates

Publication Date
20260513
Application Date
20240628

Claims (13)

  1. A method for preparing a nano protector formulation based on hyaluronic acid and amino acids for skin care and repair, characterised in that it comprises the following steps: a. PREPARING THE BASE: FORMULATION (mA). The vehicle consisting of a generic gel with zinc oxide and TiO2 is poured into a sterilised (preferably glass) container using only physical filters and left to stand for at least ten minutes at a temperature comprised between 17° and 25°C; rosewater is added stirring vigorously at a constant speed of preferably 50 rpm for at least two minutes; tannins, preferably in powder form, are then added increasing the stirring speed to a range between 110 and 130 rpm until obtaining a homogeneous mixture without agglutination and left to stand for at least 15 minutes; (this preparation is mA) b. PREPARING mA ADDED WITH VITAMINS. FORMULATION (mB). Once the standing time of the preceding step has elapsed, the mixture mA is heated until its temperature is raised to at least 55°C stirring constantly throughout the entire period in which the temperature rises at a speed of 50 rpm until the homogeneity thereof is achieved every time that each vitamin is added and, without stopping the stirring, vitamin B5 is first added, then vitamin E and finally vitamin C, continuing the stirring for at least three more minutes; this mixture is left to stand for the time necessary for its temperature to drop to at least 35°C (this preparation is mB); c. PREPARING HYALURONIC ACID. FORMULATION (mC) Hyaluronic acid is poured into a container which is different from that used in the preceding steps in controlled temperature conditions, ensuring that it is contained between 20°C and 30°C, pycnogenol and aqueous honey extract are added at a constant speed of 100 rpm; stirring is maintained for at least four minutes and left to stand for at least five more minutes; (this preparation is mC); d. OBTAINING HOMOGENEOUS MIXING BETWEEN mB and mC. FORMULATION (mD). When the temperature of the mixture mB obtained has dropped to 35°C, mB is mixed with mC and the temperature is raised again until reaching a range between 35°C and 45°C stirring constantly at 130 rpm for at least five minutes until achieving a homogeneous mixture again and the temperature is lowered to 25°C, leaving to stand in a photosensitive bottle (in this case, a dark bottle) to prevent oxidation of the formulation and the controlled temperature must be maintained for at least ten more minutes; (this preparation is mD); e. ADDING NANOPARTICLES. Once the standing time of the preparation mixture of the preceding step has elapsed, it is stirred in a range comprised between 130 and 160 rpm for pouring in silver (Ag) nanoparticles until no apparent agglutination is observed and left to stand for at least seven minutes; it is then stirred again in the same range and copper oxide (CuO) nanoparticles are added and it is left to stand again for at least ten minutes; finally it is packaged in a photosensitive container (preferably an amber container) and, in order to maintain the optimal conditions of the mixture, it is kept in a cool dry place at a temperature comprised between 25°C and 33°C.
  2. A formulation obtained with the method of claim 1, characterised in that it comprises two homogeneous mixtures which, when taking one unit of the formulation, each compound is present in the mixture per 100 ml: i. At least two aqueous extracts; the former being present in the mixture in a concentration range comprised between 2% and 4% and the second in a range comprised between 8% and 12%; ii. Vitamins: at least in three types of different concentrations: the first being vitamin C (ascorbic acid) in a range comprised between 8% and 12%; the second being vitamin E (tocopherol acetate) in a range comprised between 3% and 7%; the third being vitamin B5 (D-panthenol with allantoin) in a range comprised between 2% and 6%; iii. Hydrolysed hyaluronic acid in a range comprised between 2% and 3%; iv. Nanoparticles of two types in different concentrations; the first being dry sphere silver (Ag) nanoparticles having a size comprised in a range of between 70 nm and 100 nm, present in the mixture in a range comprised between 0.5% and 1.5%; the second being dry sphere copper oxide (CuO) nanoparticles having a size comprised in a range of between 30 nm and 60 nm, present in the mixture in a range comprised between 0.1% and 1%; v. Pycnogenol, present in the mixture in a range comprised between 2% and 6%; vi. Tannins (preferably in powder form) present in the mixture in a range comprised between 2% and 4%; and vii. A generic base or vehicle containing zinc and TiO 2 physical filters only.
  3. USE of the formulation of claim 2, characterised in that it has HYDRATING effects when mixed with at least one lipid from the following group: ceramides (50-60%), cholesterol and polyunsaturated fatty acids; being present in one unit (100 ml) as follows: a) The formulation in a preferred range comprised between 1% and 45% present in the mixture; b) A lipid in a preferred range comprised between 99% and 55% present in the mixture; and c) An excipient.
  4. USE of the formulation of claim 2, characterised in that it has REPAIRING effects when mixed with collagen; being present in one unit (100 ml) as follows: a) The formulation in a preferred range comprised between 1% and 55% present in the mixture; b) Collagen in a preferred range comprised between 95% and 45% present in the mixture; and c) An excipient.
  5. USE of the formulation of claim 2, characterised in that it has DEPIGMENTING effects when mixed with phytic acid, lipoic acid, ellagic acid, lactic acid, salicylic acid, azelaic acid, together with plant extracts derived from bearberry, liquorice or mulberry; being present in one unit (100 ml) as follows: a) The formulation in a preferred range comprised between 1% and 45% present in the mixture; b) An acid in a preferred range comprised between 99% and 55% present in the mixture; and c) An excipient.
  6. USE of the formulation of claim 2, characterised in that it has NUTRITIVE effects when mixed with vitamins A, B, C, D, E, K; being present in one unit (100 ml) as follows: d) The formulation in a preferred range comprised between 1% and 45% present in the mixture; e) An acid in a preferred range comprised between 99% and 55% present in the mixture; and f) An excipient.
  7. USE of the formulation of claim 2, characterised in that it has PROTECTIVE effects when mixed with a compound from any of the group: methyl cinnamate, avobenzone, octisalate; salicylate; being present in one unit (100 ml) as follows: a) The formulation in a preferred range comprised between 1% and 45% present in the mixture; b) At least one compound in a preferred range comprised between 99% and 55% present in the mixture; and c) An excipient.
  8. THE formulations of claims 2 to 7, characterised in that their dosage form is a TOPICAL CREAM which allows direct application on skin before sun exposure in a time range that ranges between 10 and 50 min.
  9. THE formulations of claims 2 to 7, characterised in that their dosage form is a GEL which allows direct application on skin after sun exposure in a time range that ranges between 30 and 60 min.
  10. THE formulations of claims 2 to 7, characterised in that their dosage form is a BODY CREAM which allows direct application on skin after bath or shower, in a time range that ranges between 0.1 and 20 min.
  11. THE formulations of claims 2 to 7, characterised in that their dosage form is a CAPSULE which allows ingestion in a dose of 100 mg every 24 hours for 3 days prior to the time of sun exposure.
  12. THE formulations of claims 2 to 7, characterised in that their dosage form is a TABLET which allows ingestion in a dose of 100 mg every 24 hours for 3 days prior to the time of sun exposure.
  13. THE formulations of claims 2 to 7, characterised in that their dosage form is a LYOPHILISED POWDER which allows reconstitution with double distilled water prior to its application.

Description

FIELD OF THE INVENTION The present invention relates to a new formulation based on hyaluronic acid and other amino acids that hydrate, repair, brighten, nourish, and protect the skin and defend it topically against all pathogens, but which has a completely different mechanism of action from those disclosed in the prior art. Therefore, is considered to be a biotechnological invention. BACKGROUND Various applications of hyaluronic acid in cosmetic inventions, particularly its inclusion in formulations with different compounds that help or allow its absorption into the skin, have been disclosed in the state of the art, so comparisons of the effects achieved by the different formulations could begin to be made. In this case, it can be found in the state of the art at least one formulation that delivers basic organic molecules and amino acids to the skin, however, in a completely separate manner, each one of them serves some technical effect such as reducing hyperpigmentation, hydrating, stimulating collagen production and eliminating bacteria, fungi and viruses that may affect the skin, some others allow repairing skin tissue, generating a polarising effect and protecting against radiation; such as those set out below. Russian patent RU2138245 (C1) entitled "Cosmetic composition for the protection of skin and/or hair from ultraviolet rays, method for the cosmetic protection of skin and/or hair from ultraviolet radiations, agent for reducing the composition containing titanium dioxide pigments, method for reducing the composition containing titanium dioxide-based pigments"; this invention relates to a substantially anhydrous liquid concentrate which comprises dissolved micronutrients in an amount between 0.3% by weight and 5% by weight of metal ions, chosen from zinc, manganese, selenium, iron, copper, cobalt, molybdenum and magnesium and mixtures thereof, 0.3% by weight of carboxylic acid compound which is soluble in glycol, and at least 40% by weight of a glycol compound, wherein the glycol compound is a compound comprising an α,ω-ethyldiol group, optionally comprising ethyl ether groups. The main claims of the invention include a cosmetic composition for protecting skin and/or hair from ultraviolet rays by means of topical application, characterised in that it comprises in a cosmetically acceptable carrier at least one acyl glutamate and at least one amphiphilic ionic lipid selected from acylamino acids. Argentinian patent AR 069973, entitled "Gel technology suitable for use in cosmetic compositions", discloses a gel system comprising a fractal network of nanoparticles and macroscopic particles. The gel system is capable of forming an effective "optical gel" for blurring lines and wrinkles as a result of the size domain differences between fractal particles and macroscopic particles. Cosmetic compositions comprising such gels and methods for use thereof are also disclosed. Claim 2: The cosmetic composition of claim 1, wherein the nanoparticles are inorganic nanoparticles having a particle size ranging from about 50 to 900 nanometres and a refractive index ranging from about 1.38 to about 2. Claim 3: The cosmetic composition of claim 2, wherein the inorganic nanoparticles are silica, alumina, titania, zirconia, zinc oxide, indium-doped tin oxide, cerium, or mixtures thereof and wherein the macroscopic particles are selected from the group consisting of silicone elastomers; silicone crosspolymers; hydrocarbon elastomers; natural and synthetic rubbers; polymeric spheres, and compatible combinations thereof. Claim 4: The composition of claim 3, wherein the polymeric spheres are selected from the group consisting of fluoropolymers, polyacrylates, nylon, polyesters, cellulose capsules, polyurethanes, polyacrylic esters, polyethers, polyamides, polyesteramides, polyurethanes, and mixtures thereof. Claim 14: The cosmetic composition of claim 3, wherein the gel is an aqueous dispersion of first nanoparticles and second nanoparticles having a specific pH, and the first and second nanoparticles have oppositely charged zeta potentials at said pH. Claim 16: The cosmetic composition of claim 3, wherein the cosmetic composition is substantially anhydrous and the gel further comprises a non-aqueous solvent. Claim 21: A substantially anhydrous cosmetic composition comprising a gel comprising (a) a fractal network of nanoparticles; (b) translucent macroscopic particles and (c) a non-aqueous solvent, and the refractive index of the nanoparticles does not match the refractive index of the macroscopic particles. Claim 32: A method for optically blurring the appearance of skin imperfections selected from the group consisting of wrinkles, fine lines, and pores comprising the step of applying to the skin an amount of a skin care or make-up composition effective to optically blur the appearance of said skin imperfection, and the composition comprises a gel system comprising (a) a fractal network of nanoparticles; and (b) translucent