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EP-4741157-A1 - HYDROPHILIC EPTFE SHEET AND METHOD FOR MAKING EPTFE SHEET HYDROPHILIC

EP4741157A1EP 4741157 A1EP4741157 A1EP 4741157A1EP-4741157-A1

Abstract

It is intended to provide a hydrophilized ePTFE sheet enhanced in hydrophilic property so as to be made usable for applications such as embedment in a human body and attachment to the surface of an organ or so forth. The present hydrophilized ePTFE sheet (10) includes an ePTFE sheet (12), Japanese paper (14) laminated on the surface of the ePTFE sheet (12) processed with an atmospheric pressure plasma treatment, and a collagen layer (16) applied to the surface of the Japanese paper (14).

Inventors

  • SAWADA, MAKOTO

Assignees

  • Saikyo Biotech Co., Ltd.

Dates

Publication Date
20260513
Application Date
20230706

Claims (4)

  1. A hydrophilized ePTFE sheet comprising: an ePTFE sheet; Japanese paper laminated on a surface of the ePTFE sheet processed with an atmospheric pressure plasma treatment; and a collagen layer applied to a surface of the Japanese paper.
  2. The hydrophilized ePTFE sheet according to claim 1, wherein the collagen layer has a surface irradiated with an ion beam.
  3. A method of hydrophilizing an ePTFE sheet, the method comprising: processing a surface of the ePTFE sheet with an atmospheric pressure plasma treatment; laminating Japanese paper on the surface of the ePTFE sheet processed with the atmospheric pressure plasma treatment; and applying a collagen layer to a surface of the Japanese paper.
  4. The method according to claim 3, further comprising: irradiating an ion beam to a surface of the collagen layer.

Description

FIELD OF THE INVENTION The present invention relates to a hydrophilized expanded PTFE (ePTFE) sheet with high biological affinity and a method of hydrophilizing an ePTFE sheet with high biological affinity. BACKGROUND ART The ePTFE (expanded PTFE (polytetrafluoroethylene)) is inactive, not only thin but also lightweight, and durable; hence, the ePTFE has been used for items in a variety of fields such as ground packings, gaskets, and architectural fabrics (e.g., Japan Laid-open Patent Application Publication No. 2016-138188). PRIOR ART DOCUMENTS Patent Documents Patent Document 1: JP 2016-138188 A OVERVIEW OF THE INVENTION PROBLEM TO BE SOLVED BY THE INVENTION However, the ePTFE has had a drawback of difficulty in adherence to different other types of materials because of the hydrophobic property thereof. Especially, the ePTFE has had difficulty in use for applications utilizing the biological affinity thereof such as embedment in a human body and attachment to the surface of an organ or so forth. The present invention has been produced in view of the drawback described above; hence, it is an object of the present invention to provide not only a hydrophilized ePTFE sheet, enhanced in hydrophilic property so as to be made usable for applications such as embedment in a human body and attachment to the surface of an organ or so forth, but also a method of hydrophilizing an ePTFE sheet. MEANS FOR SOLVING THE PROBLEM According to an aspect of the present invention, a hydrophilized ePTFE sheet is provided. The hydrophilized ePTFE sheet includes an ePTFE sheet, Japanese paper laminated on a surface of the ePTFE sheet processed with an atmospheric pressure plasma treatment, and a collagen layer applied to a surface of the Japanese paper. Preferably, the collagen layer has a surface irradiated with an ion beam. According to another aspect of the present invention, a method of hydrophilizing an ePTFE sheet is provided. The method includes processing a surface of the ePTFE sheet with an atmospheric pressure plasma treatment, laminating Japanese paper on the surface of the ePTFE sheet processed with the atmospheric pressure plasma treatment, and applying a collagen layer to a surface of the Japanese paper. Preferably, the method further includes irradiating an ion beam to a surface of the collagen layer. EFFECTS OF THE INVENTION In the hydrophilized ePTFE sheet according to the present invention, the surface of the ePTFE sheet is processed with the atmospheric pressure plasma treatment. Then, the Japanese paper is laminated thereon. Furthermore, the collagen layer is applied to the surface of the Japanese paper. Accordingly, it is made possible to provide the ePTFE sheet enhanced in hydrophilic property on the surface thereof. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram exemplifying a hydrophilized ePTFE sheet (10) according to an exemplary embodiment;FIG. 2 is a diagram showing a process of manufacturing the hydrophilized ePTFE sheet (10);FIG. 3 is a diagram showing the process of manufacturing the hydrophilized ePTFE sheet (10);FIG. 4 is a diagram for explaining a contact angle;FIG. 5 is a diagram exemplifying the principle of electron beam irradiation; andFIG. 6 is a diagram exemplifying ion beam irradiation. DETAILED DESCRIPTION OF EMBODIMENTS Configuration of Hydrophilized Expanded PTFE Sheet As shown in FIG. 1, a hydrophilized ePTFE sheet 10 according to the present exemplary embodiment roughly includes an ePTFE sheet 12, Japanese paper (so-called "Washi") 14, and a collagen layer 16. It is preferable to use an ePTFE sheet with a thickness of 50 to 500 µm as the ePTFE sheet 12. As shown in FIG. 2, the surface of the ePTFE sheet 12 is processed with an atmospheric pressure plasma treatment. The ePTFE sheet 12 is hydrophobic but is enabled to be changed into being hydrophilic by the atmospheric pressure plasma treatment; hence, a cellulose film or so forth is enabled to be laminated on the ePTFE sheet, albeit not being adherent to the ePTFE sheet in nature. The Japanese paper 14 is a member laminated on the ePTFE sheet 12 surface processed with the atmospheric pressure plasma treatment. In the present specification, the Japanese paper 14 refers to a member obtained by putting plant-derived cellulose fiber into a polysaccharide aqueous solution, agitating the solution such that the plant-derived cellulose fiber can be homogeneously dispersed therein, and shaping the solution in membrane. Besides, it is preferable to use the member with a thickness of 10 to 100 µm as the Japanese paper 14. To obtain the Japanese paper 14, the cellulose fiber is of an ultrafine type obtained from, especially, the epidermis of plants such as Broussonetia kazinoki × B. papyrifera, Diplomorpha sikokiana, or Edgeworthia chrysantha, whereas the polysaccharide used for suspension is obtained from Abelmoschus manihot or so forth and has chances of being used as a food additive as well. Because of nonuse of chemicals, the Japanese p