EP-4741820-A1 - LIQUID CHROMATOGRAPH DEVICE AND CONTROL METHOD FOR SAME

EP4741820A1EP 4741820 A1EP4741820 A1EP 4741820A1EP-4741820-A1

Abstract

Provided is a liquid chromatography device capable of checking whether an analysis plan planned based on an analysis request matches an analysis process to be executed and continuing analysis even when the analysis plan does not match the analysis process. A liquid chromatography device in which a plurality of separation columns are connected to a flow path of a separation unit includes: a first storage unit configured to store an analysis process planned when an analysis is requested, an order of the analysis process, and a separation column used for the analysis; a second storage unit configured to store an analysis process planned immediately before the analysis is actually executed, an order of the analysis process, and a separation column used for the analysis; a collation unit configured to collate a content stored in the first storage unit and a content stored in the second storage unit; and a notification unit configured to notify, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, that the contents are different from each other.

Inventors

KATANO, TOSHIAKI
SAKAMOTO, Naoto

Assignees

HITACHI HIGH-TECH CORPORATION

Dates

Publication Date: 20260513
Application Date: 20240611

Claims (8)

A liquid chromatography device in which a plurality of separation columns are connected to a flow path of a separation unit, the liquid chromatography device comprising: a first storage unit configured to store an analysis process planned when an analysis is requested, an order of the analysis process, and a separation column used for the analysis; a second storage unit configured to store an analysis process planned immediately before the analysis is actually executed, an order of the analysis process, and a separation column used for the analysis; a collation unit configured to collate a content stored in the first storage unit and a content stored in the second storage unit; and a notification unit configured to notify, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, that the contents are different from each other.
The liquid chromatography device according to claim 1, further comprising: a checking unit configured to check, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit; and a control unit configured to execute, when the checking unit confirms that there is the separation column available for the analysis process, a control to continue the analysis using the separation column.
The liquid chromatography device according to claim 1, further comprising: a checking unit configured to check, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit; and a control unit configured to execute a control to interrupt the analysis on a specimen requested to be analyzed when the checking unit confirms that there is no separation column available for the analysis process.
The liquid chromatography device according to claim 1, further comprising: a checking unit configured to check, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit; and a control unit configured to execute, when the checking unit confirms that there is no separation column available for the analysis process, a control to continue the analysis using the separation column which is used for the analysis stored in the second storage unit after an analysis preparation is executed, the analysis preparation including cleaning the separation column such that the analysis stored in the second storage unit is executable.
A control method for a liquid chromatography device in which a plurality of separation columns are connected to a flow path of a separation unit, the control method comprising: a step of storing, in a first storage unit, an analysis process planned when an analysis is requested, an order of the analysis process, and a separation column used for the analysis; a step of storing, in a second storage unit, an analysis process planned immediately before the analysis is actually executed, an order of the analysis process, and a separation column used for the analysis; a collation step of collating the content stored in the first storage unit and the content stored in the second storage unit; and a notification step of notifying, when it is determined in the collation step that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, that the contents are different from each other.
The control method for a liquid chromatography device according to claim 5, further comprising: a checking step of checking, when it is determined in the collation step that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit, wherein when it is confirmed in the checking step that there is the separation column available for the analysis process, the analysis is continued using the separation column.
The control method for a liquid chromatography device according to claim 5, further comprising: a checking step of checking, when it is determined in the collation step that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit, wherein the analysis on a specimen requested to be analyzed is interrupted when it is confirmed in the checking step that there is no separation column available for the analysis process.
The control method for a liquid chromatography device according to claim 5, further comprising: a checking step of checking, when it is determined in the collation step that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, whether there is a separation column available for the analysis process stored in the first storage unit among separation columns different from the separation column used for the analysis stored in the second storage unit, wherein when it is confirmed in the checking step that there is no separation column available for the analysis process, the analysis is continued using the separation column which is used for the analysis stored in the second storage unit after an analysis preparation is executed, the analysis preparation including cleaning the separation column such that the analysis stored in the second storage unit is executable.

Description

Technical Field The present invention relates to a liquid chromatography device and a control method therefor. Background Art Automatic analyzers for automatically analyzing biological samples such as blood and urine are widely used in hospitals and examination centers. In such an automatic analyzer, an analysis plan is made in the device as to which item is to be analyzed for a sample collected from a patient and in what order the analysis is to be performed in accordance with an instruction (order) of a doctor. However, in the automatic analyzer, different biological samples are simultaneously analyzed in parallel, and an initial analysis plan and an actually performed analysis may be different due to an emergency sample being added in response to an emergency patient. In this case, an abnormal process may be erroneously performed. PTL 1 discloses a technique of collating an analysis plan created at the time of an analysis request with an actually performed analysis, verifying whether there is an abnormal process, and improving reliability of an analysis process. Citation List Patent Literature PTL 1: JP2014-228289A Summary of Invention Technical Problem PTL 1 does not consider a liquid chromatography device including a plurality of flow paths (streams) including a separation column. Therefore, if it is found that the analysis plan immediately before the execution does not match the analysis plan planned based on the analysis request, the analysis may be continued without being interrupted if the analysis is performed in another stream. An object of the present invention is to provide a liquid chromatography device that verifies whether there is an abnormal process in an analysis, improves reliability of an analysis process, and reduces a risk of interrupting the analysis. Solution to Problem A configuration of the invention for achieving the above object is as follows. A liquid chromatography device in which a plurality of separation columns are connected to a flow path of a separation unit, the liquid chromatography device includes: a first storage unit configured to store an analysis process planned when an analysis is requested, an order of the analysis process, and a separation column used for the analysis; a second storage unit configured to store an analysis process planned immediately before the analysis is actually executed, an order of the analysis process, and a separation column used for the analysis; a collation unit configured to collate a content stored in the first storage unit and a content stored in the second storage unit; and a notification unit configured to notify, when the collation unit determines that the content stored in the first storage unit and the content stored in the second storage unit are different from each other, that the contents are different from each other. In addition, a feature of the invention is that the analysis plan is checked before the analysis is actually performed, and if there is a problem, whether the analysis based on the analysis plan can be corrected can be examined. The technique described in PTL 1 is significantly different from the invention in that verification is performed after analysis. Advantageous Effects of Invention According to the invention, it is possible to provide a liquid chromatography device that verifies whether there is an abnormal process in an analysis, improves reliability of an analysis process, and reduces a risk of interrupting the analysis. Brief Description of Drawings [FIG. 1] FIG. 1 is a diagram showing an overall schematic configuration of a liquid chromatograph mass spectrometer.[FIG. 2] FIG. 2 is a diagram showing an example of a device state confirmation screen for the liquid chromatograph mass spectrometer.[FIG. 3] FIG. 3 is a diagram showing an example of a specimen processing confirmation screen in a preprocessing step and an analysis step executed by the liquid chromatograph mass spectrometer.[FIG. 4] FIG. 4 is a diagram showing an example of a specimen processing confirmation screen for a separation column.[FIG. 5] FIG. 5 is a diagram showing an example of a mask setting screen for a separation column.[FIG. 6] FIG. 6 shows a typical separation process scheme in the liquid chromatograph mass spectrometer.[FIG. 7] FIG. 7 shows a separation process scheme when a solvent ratio is different from that in an immediately preceding measurement.[FIG. 8] FIG. 8 shows a separation process scheme when salt may be precipitated by the immediately preceding measurement.[FIG. 9] FIG. 9 shows a flow of verification and checking according to Example 1.[FIG. 10] FIG. 10 shows a flow of verification and checking according to Example 2.[FIG. 11] FIG. 11 is a diagram showing an example of an analysis plan schedule planned when an analysis is requested. Description of Embodiments Hereinafter, a liquid chromatography device and a control method therefor will be described with reference to FIGS. 1 to 6. In the drawings used in the prese