Search

EP-4741955-A2 - SYSTEMS, DEVICES, AND METHODS TO COMPENSATE FOR TEMPERATURE EFFECTS ON SENSORS

EP4741955A2EP 4741955 A2EP4741955 A2EP 4741955A2EP-4741955-A2

Abstract

This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Inventors

  • HARLEY-TROCHIMCZYK, ANNA CLAIRE
  • REIHMAN, ELI
  • WANG, LIANG
  • DERENZY, David
  • MOORE, MICHAEL L.
  • REINHARDT, Andrew M.
  • KELLER, DAVID A.
  • CLARK, BECKY L.
  • BOHM, SEBASTIAN
  • MA, RUI
  • SHETH, DISHA B.
  • SHI, MINGLIAN
  • TURKSOY, KAMURAN
  • CRABTREE, Vincent P.
  • BHAVARAJU, NARESH
  • VOGEL, MATT

Assignees

  • DexCom, Inc.

Dates

Publication Date
20260513
Application Date
20190122

Claims (15)

  1. A method for temperature-compensating a continuous glucose monitoring system, the method comprising: receiving a glucose signal indicative of a glucose concentration level; receiving a temperature signal indicative of a temperature parameter; detecting a condition; and determining a temperature-compensated glucose concentration level based at least in part on the glucose signal, the temperature signal, and the detected condition; wherein the glucose signal is received from a continuous glucose sensor, and the condition is compression on a continuous glucose sensor; and wherein the compression is detected based at least in part upon a rapid drop in the glucose signal and a rise in temperature indicated by the temperature signal.
  2. The method of claim 1, wherein the compression is detected based at least in part on a rapid drop in the glucose signal simultaneous with or followed by an increase in temperature.
  3. The method of claim 1 or claim 2, wherein the compression is detected based at least in part on a rapid drop in the glucose signal, a rise in temperature and activity information indicating low activity.
  4. The method of any preceding claim, further comprising triggering an alert in response to detection of the compression.
  5. The method of claim 4, wherein triggering an alert results in a notification being delivered via a smart device.
  6. The method of claim 4, wherein triggering an alert results in a sound being emitted from a smart device.
  7. The method of any preceding claim, wherein the condition is compression during sleep.
  8. The method of any preceding claim, wherein the continuous glucose sensor includes an analyte sensor region and wherein the temperature signal is generated by a temperature sensor at or near the analyte sensor region.
  9. The method of claim 7, wherein the temperature sensor is a thermocouple or a thermistor or a diode.
  10. A temperature-compensated glucose monitoring system comprising: a glucose sensor circuit configured to generate a glucose signal representative of a glucose concentration level; a temperature sensor circuit configured to generate a temperature signal indicative of a temperature parameter; and a processor configured to determine a compensated glucose concentration level based on the glucose signal, the temperature signal, and a detected condition; wherein: the condition is compression of a continuous glucose sensor; and the processor is configured to detect the compression based at least in part upon a rapid drop in the glucose signal and a rise in temperature indicated by the temperature signal.
  11. The system of claim 10, wherein the processor is configured to detect the compression based at least in part on a rapid drop in the glucose signal simultaneous with or followed by an increase in temperature.
  12. The system of claim 10 or claim 11, wherein the processor is configured to detect the compression based at least in part on a rapid drop in the glucose signal, a rise in temperature and activity information indicating low activity.
  13. The system of any of claims 10 to 12, wherein the system is configured to trigger an alert in response to detection of the compression.
  14. The system of any of claims 10 to 13, wherein the condition is compression during sleep.
  15. The system of any of claims 10-14, wherein the glucose sensor circuit includes a continuous glucose sensor with an analyte sensor region, and the temperature sensor circuit includes a temperature sensor at or near the analyte sensor region.

Description

INCORPORATION BY REFERENCE TO RELATED APPLICATIONS Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application claims the benefit of U.S. Provisional Application No. 62/620,775, filed January 23, 2018. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification. TECHNICAL FIELD The present development relates generally to medical devices such as analyte sensors, and more particularly, but not by way of limitation, to systems, devices, and methods to compensate for effects of temperature on analytes sensors. BACKGROUND Diabetes is a metabolic condition relating to the production or use of insulin by the body. Insulin is a hormone that allows the body to use glucose for energy, or store glucose as fat. When a person eats a meal that contains carbohydrates, the food is processed by the digestive system, which produces glucose in the person's blood. Blood glucose can be used for energy or stored as fat. The body normally maintains blood glucose levels in a range that provides sufficient energy to support bodily functions and avoids problems that can arise when glucose levels are too high, or too low. Regulation of blood glucose levels depends on the production and use of insulin, which regulates the movement of blood glucose into cells. When the body does not produce enough insulin, or when the body is unable to effectively use insulin that is present, blood sugar levels can elevate beyond normal ranges. The state of having a higher than normal blood sugar level is called "hyperglycemia." Chronic hyperglycemia can lead to a number of health problems, such as cardiovascular disease, cataract and other eye problems, nerve damage (neuropathy), and kidney damage. Hyperglycemia can also lead to acute problems, such as diabetic ketoacidosis - a state in which the body becomes excessively acidic due to the presence of blood glucose and ketones, which are produced when the body cannot use glucose. The state of having lower than normal blood glucose levels is called "hypoglycemia." Severe hypoglycemia can lead to acute crises that can result in seizures or death. A diabetes patient can receive insulin to manage blood glucose levels. Insulin can be received, for example, through a manual injection with a needle. Wearable insulin pumps are also available. Diet and exercise also affect blood glucose levels. A glucose sensor can provide an estimated glucose concentration level, which can be used as guidance by a patient or caregiver. Diabetes conditions are sometimes referred to as "Type 1" and "Type 2". A Type 1 diabetes patient is typically able to use insulin when it is present, but the body is unable to produce sufficient amounts of insulin, because of a problem with the insulin-producing beta cells of the pancreas. A Type 2 diabetes patient may produce some insulin, but the patient has become "insulin resistant" due to a reduced sensitivity to insulin. The result is that even though insulin is present in the body, the insulin is not sufficiently used by the patient's body to effectively regulate blood sugar levels. This Background is provided to introduce a brief context for the Summary and Detailed Description that follow. This Background is not intended to be an aid in determining the scope of the claimed subject matter nor be viewed as limiting the claimed subject matter to implementations that solve any or all of the disadvantages or problems presented above. SUMMARY This document discusses, among other things, systems, devices, and methods to determine subcutaneous temperatures or compensate for the effects of temperature on an analyte sensor, such as a glucose sensor. An Example (e.g., "Example 1") of subject matter (e.g., a system) may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter. In Example 2, the subject matter of Example 1 may optionally be configured such that the temperature parameter is a temperature, a temperature change, or a temperature offset. In Example 3, the subject matter of any one or more of Examples 1-2 may optionally be configured such that the temperature parameter is detected at a first time and the glucose concentration level is detected at a second time after the first time may be configured such that the delay parameter includes a delay time period between the first time and the second time that accounts for a de